Effects of royal jelly consumption on clinical outcomes in patients with ischemic stroke: A triple-blind randomized controlled trial
The therapeutic impact of royal jelly (RJ) consumption in patients with ischemic stroke is unknown. Therefore, we conducted a randomized, triple-blind, placebo-controlled clinical trial to evaluate the role of RJ supplementation on clinical and biochemical outcomes in patients recovering from ischem...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464625000301 |
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| author | Elham Karimi Arman Arab Fariborz Khorvash Maryam Kazemi Reza Amani |
| author_facet | Elham Karimi Arman Arab Fariborz Khorvash Maryam Kazemi Reza Amani |
| author_sort | Elham Karimi |
| collection | DOAJ |
| description | The therapeutic impact of royal jelly (RJ) consumption in patients with ischemic stroke is unknown. Therefore, we conducted a randomized, triple-blind, placebo-controlled clinical trial to evaluate the role of RJ supplementation on clinical and biochemical outcomes in patients recovering from ischemic stroke. Out of 64 enrolled patients (45–80 yrs.) with ischemic stroke, 32 were randomized to the RJ group and 32 to the placebo (control) group. Groups completed a 12-week intervention. The intervention group received 1000 mg/d of RJ dragee after breakfast. We evaluated stroke-related disability, quality of life, and inflammatory and oxidative stress markers at baseline and post-intervention. At post-intervention, serum levels of erythrocyte sedimentation rate decreased in the RJ group compared to the control group (adjusted mean difference, −8.65 mm/h [95 % CI, −14.75 to −2.55]). Additionally, serum nitric oxide levels increased in the RJ group (adjusted mean difference, 10.18 nmol/mL [95 % CI, 0.51 to 19.86]) post-intervention compared to the control group. Furthermore, the RJ group exhibited a decreased oxidative status index (adjusted mean difference, −0.003 [95 % CI, −0.006 to −0.0001]) and reduced odds of stroke-related disability (adjusted odds ratio, 0.20 [95 % CI, 0.05 to 0.70]) compared to the placebo group. Moreover, RJ supplementation improved the quality-of-life measures in the RJ group (adjusted mean difference, 16.64 [95 % CI, 1.17 to 32.12]) compared to the control group. Our findings reflect the potential benefits of RJ consumption on clinical and biochemical outcomes of patients recovering from ischemic stroke. Importantly, we acknowledge the necessity of additional studies to verify the efficacy of RJ supplementation in patients recovering from strokes. Trial registration: Iranian Registry of Clinical Trials (IRCT20180818040827N4), registered on October 9, 2021; https://www.irct.ir/trial/59275 |
| format | Article |
| id | doaj-art-4c9b271f6da84efdbb76a013479e361f |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-4c9b271f6da84efdbb76a013479e361f2025-02-09T04:59:58ZengElsevierJournal of Functional Foods1756-46462025-02-01125106688Effects of royal jelly consumption on clinical outcomes in patients with ischemic stroke: A triple-blind randomized controlled trialElham Karimi0Arman Arab1Fariborz Khorvash2Maryam Kazemi3Reza Amani4Department of Clinical Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran; Research Development Center, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, IranDivision of Sleep Medicine, Harvard Medical School, Boston, MA, USA; Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA; Corresponding authors.Isfahan Neurosciences Research Center, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USADepartment of Clinical Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran; Corresponding authors.The therapeutic impact of royal jelly (RJ) consumption in patients with ischemic stroke is unknown. Therefore, we conducted a randomized, triple-blind, placebo-controlled clinical trial to evaluate the role of RJ supplementation on clinical and biochemical outcomes in patients recovering from ischemic stroke. Out of 64 enrolled patients (45–80 yrs.) with ischemic stroke, 32 were randomized to the RJ group and 32 to the placebo (control) group. Groups completed a 12-week intervention. The intervention group received 1000 mg/d of RJ dragee after breakfast. We evaluated stroke-related disability, quality of life, and inflammatory and oxidative stress markers at baseline and post-intervention. At post-intervention, serum levels of erythrocyte sedimentation rate decreased in the RJ group compared to the control group (adjusted mean difference, −8.65 mm/h [95 % CI, −14.75 to −2.55]). Additionally, serum nitric oxide levels increased in the RJ group (adjusted mean difference, 10.18 nmol/mL [95 % CI, 0.51 to 19.86]) post-intervention compared to the control group. Furthermore, the RJ group exhibited a decreased oxidative status index (adjusted mean difference, −0.003 [95 % CI, −0.006 to −0.0001]) and reduced odds of stroke-related disability (adjusted odds ratio, 0.20 [95 % CI, 0.05 to 0.70]) compared to the placebo group. Moreover, RJ supplementation improved the quality-of-life measures in the RJ group (adjusted mean difference, 16.64 [95 % CI, 1.17 to 32.12]) compared to the control group. Our findings reflect the potential benefits of RJ consumption on clinical and biochemical outcomes of patients recovering from ischemic stroke. Importantly, we acknowledge the necessity of additional studies to verify the efficacy of RJ supplementation in patients recovering from strokes. Trial registration: Iranian Registry of Clinical Trials (IRCT20180818040827N4), registered on October 9, 2021; https://www.irct.ir/trial/59275http://www.sciencedirect.com/science/article/pii/S1756464625000301Royal jellyIschemic strokeOxidative stressInflammationQuality of life |
| spellingShingle | Elham Karimi Arman Arab Fariborz Khorvash Maryam Kazemi Reza Amani Effects of royal jelly consumption on clinical outcomes in patients with ischemic stroke: A triple-blind randomized controlled trial Journal of Functional Foods Royal jelly Ischemic stroke Oxidative stress Inflammation Quality of life |
| title | Effects of royal jelly consumption on clinical outcomes in patients with ischemic stroke: A triple-blind randomized controlled trial |
| title_full | Effects of royal jelly consumption on clinical outcomes in patients with ischemic stroke: A triple-blind randomized controlled trial |
| title_fullStr | Effects of royal jelly consumption on clinical outcomes in patients with ischemic stroke: A triple-blind randomized controlled trial |
| title_full_unstemmed | Effects of royal jelly consumption on clinical outcomes in patients with ischemic stroke: A triple-blind randomized controlled trial |
| title_short | Effects of royal jelly consumption on clinical outcomes in patients with ischemic stroke: A triple-blind randomized controlled trial |
| title_sort | effects of royal jelly consumption on clinical outcomes in patients with ischemic stroke a triple blind randomized controlled trial |
| topic | Royal jelly Ischemic stroke Oxidative stress Inflammation Quality of life |
| url | http://www.sciencedirect.com/science/article/pii/S1756464625000301 |
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