Na+,-K+-ATPase Deficiency Exacerbates Cardiac Fibrosis via Promoting ERRα-Mediated Myocardial Cell Injury and Macrophage Activation Under Isoproterenol-Challenged Conditions

Na+,-K+-ATPase Deficiency Exacerbates Cardiac Fibrosis via Promoting ERRα-Mediated Myocardial Cell Injury and Macrophage Activation Under Isoproterenol-Challenged Conditions

Background: Inflammation plays a pivotal role in the progression of tissue fibrosis. Our previous research demonstrated that Na+, K+-ATPase (NKA) α1 deficiency impairs mitochondrial function and accelerates isoproterenol (ISO)-induced cardiac remodeling. This study aims to investi...

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Bibliographic Details
Main Authors: Ting Lei, Tao Liu, Yutong Liu, Yingnan Zhai, Ruijia Wang, Xiaoyi Tan, Hongli Liu, Xiaofei Yan
Format: Article
Language:English
Published: IMR Press 2025-07-01
Series:Frontiers in Bioscience-Landmark
Subjects:
fibrosis
isoproterenol
inflammation
macrophages
mitochondria
nka
Online Access:https://www.imrpress.com/journal/FBL/30/7/10.31083/FBL40363
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