Preliminary Investigation of the Mechanical Anisotropy of the Normal Human Corneal Stroma
Purpose. To investigate the anisotropic characteristics of the normal human corneal stroma using fresh corneal tissue. Methods. Sixty-four corneal specimens extracted from stromal lenticules were included in this study. The specimens were cut in the temporal-nasal (horizontal) or superior-inferior (...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2018/5392041 |
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| author | Chao Xue Yaoqi Xiang Min Shen Di Wu Yan Wang |
| author_facet | Chao Xue Yaoqi Xiang Min Shen Di Wu Yan Wang |
| author_sort | Chao Xue |
| collection | DOAJ |
| description | Purpose. To investigate the anisotropic characteristics of the normal human corneal stroma using fresh corneal tissue. Methods. Sixty-four corneal specimens extracted from stromal lenticules were included in this study. The specimens were cut in the temporal-nasal (horizontal) or superior-inferior (vertical) direction. Strip specimens were subjected to uniaxial tensile testing. The tensile properties of the specimens were measured and compared in the two directions. Results. The low-strain tangent modulus was statistically significantly greater in the vertical direction than in the horizontal direction (1.32 ± 0.50 MPa vs 1.17 ± 0.43 MPa; P=0.035), as was the high-strain tangent modulus (51.26 ± 8.23 MPa vs 43.59 ± 7.96 MPa; P≤0.001). The elastic modulus in the vertical direction was also higher than that in horizontal direction at stresses of 0.01, 0.02, and 0.03 MPa, but not statistically significant; so, P=0.338, 0.373, and 0.417, respectively. Conclusions. The biomechanical behavior in normal human corneal stroma tissue is slightly stiffer in the vertical direction than in the horizontal direction. This information may aid our understanding of the biomechanical properties of the cornea and related diseases. |
| format | Article |
| id | doaj-art-4c952d1be5dd4ec89b7ee38611289c76 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-4c952d1be5dd4ec89b7ee38611289c762025-02-03T01:20:59ZengWileyJournal of Ophthalmology2090-004X2090-00582018-01-01201810.1155/2018/53920415392041Preliminary Investigation of the Mechanical Anisotropy of the Normal Human Corneal StromaChao Xue0Yaoqi Xiang1Min Shen2Di Wu3Yan Wang4Clinical College of Ophthalmology, Tianjin Medical University, Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Institute, Tianjin, ChinaSchool of Mechanical Engineering, Tianjin University, Tianjin, ChinaSchool of Mechanical Engineering, Tianjin University, Tianjin, ChinaClinical College of Ophthalmology, Tianjin Medical University, Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Institute, Tianjin, ChinaClinical College of Ophthalmology, Tianjin Medical University, Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Institute, Tianjin, ChinaPurpose. To investigate the anisotropic characteristics of the normal human corneal stroma using fresh corneal tissue. Methods. Sixty-four corneal specimens extracted from stromal lenticules were included in this study. The specimens were cut in the temporal-nasal (horizontal) or superior-inferior (vertical) direction. Strip specimens were subjected to uniaxial tensile testing. The tensile properties of the specimens were measured and compared in the two directions. Results. The low-strain tangent modulus was statistically significantly greater in the vertical direction than in the horizontal direction (1.32 ± 0.50 MPa vs 1.17 ± 0.43 MPa; P=0.035), as was the high-strain tangent modulus (51.26 ± 8.23 MPa vs 43.59 ± 7.96 MPa; P≤0.001). The elastic modulus in the vertical direction was also higher than that in horizontal direction at stresses of 0.01, 0.02, and 0.03 MPa, but not statistically significant; so, P=0.338, 0.373, and 0.417, respectively. Conclusions. The biomechanical behavior in normal human corneal stroma tissue is slightly stiffer in the vertical direction than in the horizontal direction. This information may aid our understanding of the biomechanical properties of the cornea and related diseases.http://dx.doi.org/10.1155/2018/5392041 |
| spellingShingle | Chao Xue Yaoqi Xiang Min Shen Di Wu Yan Wang Preliminary Investigation of the Mechanical Anisotropy of the Normal Human Corneal Stroma Journal of Ophthalmology |
| title | Preliminary Investigation of the Mechanical Anisotropy of the Normal Human Corneal Stroma |
| title_full | Preliminary Investigation of the Mechanical Anisotropy of the Normal Human Corneal Stroma |
| title_fullStr | Preliminary Investigation of the Mechanical Anisotropy of the Normal Human Corneal Stroma |
| title_full_unstemmed | Preliminary Investigation of the Mechanical Anisotropy of the Normal Human Corneal Stroma |
| title_short | Preliminary Investigation of the Mechanical Anisotropy of the Normal Human Corneal Stroma |
| title_sort | preliminary investigation of the mechanical anisotropy of the normal human corneal stroma |
| url | http://dx.doi.org/10.1155/2018/5392041 |
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