Advances in Regulatory Strategies of Differentiating Stem Cells towards Keratocytes
Corneal injury is a commonly encountered clinical problem which led to vision loss and impairment that affects millions of people worldwide. Currently, the available treatment in clinical practice is corneal transplantation, which is limited by the accessibility of donors. Corneal tissue engineering...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2022/5403995 |
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| _version_ | 1850107276003639296 |
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| author | Aini Zhang Wei Zhang Ludvig J. Backman Jialin Chen |
| author_facet | Aini Zhang Wei Zhang Ludvig J. Backman Jialin Chen |
| author_sort | Aini Zhang |
| collection | DOAJ |
| description | Corneal injury is a commonly encountered clinical problem which led to vision loss and impairment that affects millions of people worldwide. Currently, the available treatment in clinical practice is corneal transplantation, which is limited by the accessibility of donors. Corneal tissue engineering appears to be a promising alternative for corneal repair. However, current experimental strategies of corneal tissue engineering are insufficient due to inadequate differentiation of stem cell into keratocytes and thus cannot be applied in clinical practice. In this review, we aim to clarify the role and effectiveness of both biochemical factors, physical regulation, and the combination of both to induce stem cells to differentiate into keratocytes. We will also propose novel perspectives of differentiation strategy that may help to improve the efficiency of corneal tissue engineering. |
| format | Article |
| id | doaj-art-4c9449f7a5da47ebaacf245ab548274a |
| institution | OA Journals |
| issn | 1687-9678 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-4c9449f7a5da47ebaacf245ab548274a2025-08-20T02:38:36ZengWileyStem Cells International1687-96782022-01-01202210.1155/2022/5403995Advances in Regulatory Strategies of Differentiating Stem Cells towards KeratocytesAini Zhang0Wei Zhang1Ludvig J. Backman2Jialin Chen3School of MedicineSchool of MedicineDepartment of Integrative Medical BiologySchool of MedicineCorneal injury is a commonly encountered clinical problem which led to vision loss and impairment that affects millions of people worldwide. Currently, the available treatment in clinical practice is corneal transplantation, which is limited by the accessibility of donors. Corneal tissue engineering appears to be a promising alternative for corneal repair. However, current experimental strategies of corneal tissue engineering are insufficient due to inadequate differentiation of stem cell into keratocytes and thus cannot be applied in clinical practice. In this review, we aim to clarify the role and effectiveness of both biochemical factors, physical regulation, and the combination of both to induce stem cells to differentiate into keratocytes. We will also propose novel perspectives of differentiation strategy that may help to improve the efficiency of corneal tissue engineering.http://dx.doi.org/10.1155/2022/5403995 |
| spellingShingle | Aini Zhang Wei Zhang Ludvig J. Backman Jialin Chen Advances in Regulatory Strategies of Differentiating Stem Cells towards Keratocytes Stem Cells International |
| title | Advances in Regulatory Strategies of Differentiating Stem Cells towards Keratocytes |
| title_full | Advances in Regulatory Strategies of Differentiating Stem Cells towards Keratocytes |
| title_fullStr | Advances in Regulatory Strategies of Differentiating Stem Cells towards Keratocytes |
| title_full_unstemmed | Advances in Regulatory Strategies of Differentiating Stem Cells towards Keratocytes |
| title_short | Advances in Regulatory Strategies of Differentiating Stem Cells towards Keratocytes |
| title_sort | advances in regulatory strategies of differentiating stem cells towards keratocytes |
| url | http://dx.doi.org/10.1155/2022/5403995 |
| work_keys_str_mv | AT ainizhang advancesinregulatorystrategiesofdifferentiatingstemcellstowardskeratocytes AT weizhang advancesinregulatorystrategiesofdifferentiatingstemcellstowardskeratocytes AT ludvigjbackman advancesinregulatorystrategiesofdifferentiatingstemcellstowardskeratocytes AT jialinchen advancesinregulatorystrategiesofdifferentiatingstemcellstowardskeratocytes |