The Relationship between Torque teno Virus and TLR2 rs5743708 Polymorphism with Breast Cancer
Introduction: Breast cancer is one of the most important causes of mortality in women. Various factors are involved in the development of cancer, including viruses. Toll-like receptors (TLRs) have an essential role in the innate immune system. The present study investigated the relationship betwe...
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Pasteur Institute of Iran
2021-09-01
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| Series: | Journal of Medical Microbiology and Infectious Diseases |
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| Online Access: | https://jommid.pasteur.ac.ir/article-1-373-en.html |
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| author | Majid Komijani Ahmad Hamta Sajedeh Khanmohamadi Hezaveh |
| author_facet | Majid Komijani Ahmad Hamta Sajedeh Khanmohamadi Hezaveh |
| author_sort | Majid Komijani |
| collection | DOAJ |
| description | Introduction: Breast cancer is one of the most important causes of mortality in
women. Various factors are involved in the development of cancer, including
viruses. Toll-like receptors (TLRs) have an essential role in the innate immune
system. The present study investigated the relationship between TLR2
rs5743708 polymorphisms and Torque teno virus (TTV) infection with breast
cancer. Methods: Blood samples from 80 women with breast cancer and 80
healthy women were collected, and after DNA extraction, the presence of TTV
was investigated by a PCR assay and polymorphism in the TLR2 gene
(rs5743708) was explored using the PCR-RFLP method. Also, the physical and
chemical properties of TLR2 protein in the two wild and mutant forms were
analyzed using the ExPASy database. Results: Statistical analysis showed that
there was no significant relationship between the age and TTV infection; TTV
infection and breast cancer; the grade of cancer, and TTV infection; while there
were significant relationships between rs5743708 polymorphisms and breast
cancer; GG genotype and increased incidence of cancer; TTV infection and
rs5743708 polymorphisms. Also, instability index, aliphatic index, grand
average of hydropathicity, and molecular weight of TLR2 protein varied in wild
and mutant states. Conclusions: Although there was no significant relationship
between TTV infection and breast cancer, the rs5743708 polymorphisms might
be involved in TTV infection and breast cancer. |
| format | Article |
| id | doaj-art-4c883783e0014b67b6d429303bd564eb |
| institution | Kabale University |
| issn | 2345-5349 2345-5330 |
| language | English |
| publishDate | 2021-09-01 |
| publisher | Pasteur Institute of Iran |
| record_format | Article |
| series | Journal of Medical Microbiology and Infectious Diseases |
| spelling | doaj-art-4c883783e0014b67b6d429303bd564eb2025-08-20T03:52:20ZengPasteur Institute of IranJournal of Medical Microbiology and Infectious Diseases2345-53492345-53302021-09-019311612110.52547/JoMMID.9.3.116The Relationship between Torque teno Virus and TLR2 rs5743708 Polymorphism with Breast CancerMajid Komijani0https://orcid.org/0000-0001-6206-5190Ahmad Hamta1https://orcid.org/0000-0003-4681-4731Sajedeh Khanmohamadi Hezaveh2https://orcid.org/0000-0003-4840-1885Department of Biology, Faculty of Science, Arak University, Arak, 38156-8-8349, IranDepartment of Biology, Faculty of Science, Arak University, Arak, 38156-8-8349, IranDepartment of Biology, Faculty of Science, Arak University, Arak, 38156-8-8349, IranIntroduction: Breast cancer is one of the most important causes of mortality in women. Various factors are involved in the development of cancer, including viruses. Toll-like receptors (TLRs) have an essential role in the innate immune system. The present study investigated the relationship between TLR2 rs5743708 polymorphisms and Torque teno virus (TTV) infection with breast cancer. Methods: Blood samples from 80 women with breast cancer and 80 healthy women were collected, and after DNA extraction, the presence of TTV was investigated by a PCR assay and polymorphism in the TLR2 gene (rs5743708) was explored using the PCR-RFLP method. Also, the physical and chemical properties of TLR2 protein in the two wild and mutant forms were analyzed using the ExPASy database. Results: Statistical analysis showed that there was no significant relationship between the age and TTV infection; TTV infection and breast cancer; the grade of cancer, and TTV infection; while there were significant relationships between rs5743708 polymorphisms and breast cancer; GG genotype and increased incidence of cancer; TTV infection and rs5743708 polymorphisms. Also, instability index, aliphatic index, grand average of hydropathicity, and molecular weight of TLR2 protein varied in wild and mutant states. Conclusions: Although there was no significant relationship between TTV infection and breast cancer, the rs5743708 polymorphisms might be involved in TTV infection and breast cancer.https://jommid.pasteur.ac.ir/article-1-373-en.htmlvirussingle nucleotide polymorphismsbreast cancertolllike receptor |
| spellingShingle | Majid Komijani Ahmad Hamta Sajedeh Khanmohamadi Hezaveh The Relationship between Torque teno Virus and TLR2 rs5743708 Polymorphism with Breast Cancer Journal of Medical Microbiology and Infectious Diseases virus single nucleotide polymorphisms breast cancer tolllike receptor |
| title | The Relationship between Torque teno Virus and TLR2 rs5743708 Polymorphism with Breast Cancer |
| title_full | The Relationship between Torque teno Virus and TLR2 rs5743708 Polymorphism with Breast Cancer |
| title_fullStr | The Relationship between Torque teno Virus and TLR2 rs5743708 Polymorphism with Breast Cancer |
| title_full_unstemmed | The Relationship between Torque teno Virus and TLR2 rs5743708 Polymorphism with Breast Cancer |
| title_short | The Relationship between Torque teno Virus and TLR2 rs5743708 Polymorphism with Breast Cancer |
| title_sort | relationship between torque teno virus and tlr2 rs5743708 polymorphism with breast cancer |
| topic | virus single nucleotide polymorphisms breast cancer tolllike receptor |
| url | https://jommid.pasteur.ac.ir/article-1-373-en.html |
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