Efficacy of a Single Injection of Stromal Vascular Fraction in Dogs with Elbow Osteoarthritis: A Clinical Prospective Study
This study aimed to assess the efficacy of a single intra-articular injection of autologous stromal vascular fraction (SVF) in dogs with chronic lameness due to advanced elbow osteoarthritis (OA) that were unresponsive to conventional drug therapy. In this clinical, prospective, non-blinded, single-...
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MDPI AG
2024-09-01
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| Online Access: | https://www.mdpi.com/2076-2615/14/19/2803 |
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| author | Yvonne Bruns Maike Schroers Stephanie Steigmeier-Raith Anja-Christina Waselau Sven Reese Andrea Meyer-Lindenberg |
| author_facet | Yvonne Bruns Maike Schroers Stephanie Steigmeier-Raith Anja-Christina Waselau Sven Reese Andrea Meyer-Lindenberg |
| author_sort | Yvonne Bruns |
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| description | This study aimed to assess the efficacy of a single intra-articular injection of autologous stromal vascular fraction (SVF) in dogs with chronic lameness due to advanced elbow osteoarthritis (OA) that were unresponsive to conventional drug therapy. In this clinical, prospective, non-blinded, single-center study, twenty-three dogs received autologous SVF derived from falciform adipose tissue. Primary outcome measures over the six-month study period included clinical-orthopedic and radiographic examinations, objective gait analysis and validated owner questionnaires. In 19 of 23 joints, no progression of OA was visible radiographically. Peak vertical force improved significantly at three months and vertical impulse at six months after the injection compared to baseline. Over 33% of dogs demonstrated treatment-related improvements in lameness based on objective gait analysis. Owner questionnaires indicated significant improvement in clinical signs throughout the study period and 26% of dogs showed treatment-related improvements in pain scores according to the Canine Brief Pain Inventory. No side effects were reported. These findings suggest that autologous regenerative cell therapy may provide a promising treatment option for dogs with advanced OA that do not respond to conventional drug therapy. However, the treatment did not improve the clinical symptoms in all dogs, so it cannot be recommended for all patients. |
| format | Article |
| id | doaj-art-4c8174afb2f848cfa583eff925e03de9 |
| institution | OA Journals |
| issn | 2076-2615 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | MDPI AG |
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| series | Animals |
| spelling | doaj-art-4c8174afb2f848cfa583eff925e03de92025-08-20T01:47:44ZengMDPI AGAnimals2076-26152024-09-011419280310.3390/ani14192803Efficacy of a Single Injection of Stromal Vascular Fraction in Dogs with Elbow Osteoarthritis: A Clinical Prospective StudyYvonne Bruns0Maike Schroers1Stephanie Steigmeier-Raith2Anja-Christina Waselau3Sven Reese4Andrea Meyer-Lindenberg5Clinic of Small Animal Surgery and Reproduction, Ludwig-Maximilians-Universität München, 80539 Munich, GermanyClinic of Small Animal Surgery and Reproduction, Ludwig-Maximilians-Universität München, 80539 Munich, GermanyClinic of Small Animal Surgery and Reproduction, Ludwig-Maximilians-Universität München, 80539 Munich, GermanyClinic of Small Animal Surgery and Reproduction, Ludwig-Maximilians-Universität München, 80539 Munich, GermanyDepartment of Veterinary Sciences, Ludwig-Maximilians-Universität München, 80539 Munich, GermanyClinic of Small Animal Surgery and Reproduction, Ludwig-Maximilians-Universität München, 80539 Munich, GermanyThis study aimed to assess the efficacy of a single intra-articular injection of autologous stromal vascular fraction (SVF) in dogs with chronic lameness due to advanced elbow osteoarthritis (OA) that were unresponsive to conventional drug therapy. In this clinical, prospective, non-blinded, single-center study, twenty-three dogs received autologous SVF derived from falciform adipose tissue. Primary outcome measures over the six-month study period included clinical-orthopedic and radiographic examinations, objective gait analysis and validated owner questionnaires. In 19 of 23 joints, no progression of OA was visible radiographically. Peak vertical force improved significantly at three months and vertical impulse at six months after the injection compared to baseline. Over 33% of dogs demonstrated treatment-related improvements in lameness based on objective gait analysis. Owner questionnaires indicated significant improvement in clinical signs throughout the study period and 26% of dogs showed treatment-related improvements in pain scores according to the Canine Brief Pain Inventory. No side effects were reported. These findings suggest that autologous regenerative cell therapy may provide a promising treatment option for dogs with advanced OA that do not respond to conventional drug therapy. However, the treatment did not improve the clinical symptoms in all dogs, so it cannot be recommended for all patients.https://www.mdpi.com/2076-2615/14/19/2803osteoarthritiscubarthrosisregenerative cellsstromal vascular fractiondog |
| spellingShingle | Yvonne Bruns Maike Schroers Stephanie Steigmeier-Raith Anja-Christina Waselau Sven Reese Andrea Meyer-Lindenberg Efficacy of a Single Injection of Stromal Vascular Fraction in Dogs with Elbow Osteoarthritis: A Clinical Prospective Study Animals osteoarthritis cubarthrosis regenerative cells stromal vascular fraction dog |
| title | Efficacy of a Single Injection of Stromal Vascular Fraction in Dogs with Elbow Osteoarthritis: A Clinical Prospective Study |
| title_full | Efficacy of a Single Injection of Stromal Vascular Fraction in Dogs with Elbow Osteoarthritis: A Clinical Prospective Study |
| title_fullStr | Efficacy of a Single Injection of Stromal Vascular Fraction in Dogs with Elbow Osteoarthritis: A Clinical Prospective Study |
| title_full_unstemmed | Efficacy of a Single Injection of Stromal Vascular Fraction in Dogs with Elbow Osteoarthritis: A Clinical Prospective Study |
| title_short | Efficacy of a Single Injection of Stromal Vascular Fraction in Dogs with Elbow Osteoarthritis: A Clinical Prospective Study |
| title_sort | efficacy of a single injection of stromal vascular fraction in dogs with elbow osteoarthritis a clinical prospective study |
| topic | osteoarthritis cubarthrosis regenerative cells stromal vascular fraction dog |
| url | https://www.mdpi.com/2076-2615/14/19/2803 |
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