A nomogram model based on tumor necrosis factor-like ligand 1A(TL1A) and death receptor-3(DR3) promoter methylation for predicting 90-day prognosis in patients with HBV-associated acute-on-chronic liver failure

A nomogram model based on tumor necrosis factor-like ligand 1A(TL1A) and death receptor-3(DR3) promoter methylation for predicting 90-day prognosis in patients with HBV-associated acute-on-chronic liver failure

PurposeAcute-on-chronic liver failure (ACLF) associated with hepatitis-B-virus (HBV) is a life-threatening condition characterized by severe hepatic dysfunction. The TL1A/DR3 signaling axis modulates immune responses and contributes to hepatic inflammation. This study aimed to investigate the methyl...

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Bibliographic Details
Main Authors: Xue-Fei Wei, Feng Zhang, Han-Xu Zhu, Zhe-Zhe Tian, Miao-Miao Xu, Yu-Chen Fan, Kai Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Molecular Biosciences
Subjects:
HBV-ACLF
methylation
noninvasive model
prognosis
TL1A/DR3
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2025.1614311/full
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