A 10-Year Observational Study on Treatment Approaches in Pemphigus and Pemphigoid
Objectives: The aim of this study was to evaluate epidemiological data on pemphigus vulgaris and pemphigoid, with special focus on characteristics, clinical manifestations, and treatment approaches. Materials and methods: This study includes patients who have been diagnosed with pemphigus vulgaris...
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University of Zagreb. School of Dental Medicine
2025-01-01
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| Series: | Acta Stomatologica Croatica |
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| Online Access: | https://hrcak.srce.hr/file/480583 |
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| author | Cristiana Palmela Pereira Rui Santos Leonor Ferreira Matilde Martins Ana Rodrigues Diana Augusto Paulo Filipe |
| author_facet | Cristiana Palmela Pereira Rui Santos Leonor Ferreira Matilde Martins Ana Rodrigues Diana Augusto Paulo Filipe |
| author_sort | Cristiana Palmela Pereira |
| collection | DOAJ |
| description | Objectives: The aim of this study was to evaluate epidemiological data on pemphigus vulgaris and
pemphigoid, with special focus on characteristics, clinical manifestations, and treatment approaches. Materials and methods: This study includes patients who have been diagnosed with pemphigus vulgaris or pemphigoid at the Dermatology Service of the Santa Maria Local Health Unit between the years 2013 and 2022. The statistical software IBM SPSS® version 29, with Clopper-Pearson 95% confidence intervals (CI) was used for proportions. Results: The total number of patients included in this study is 99 patients with pemphigus vulgaris (49 females, 50 males) and 227 with pemphigoid patients (108 females, 119 males). Patients who have been treated for pemphigus vulgaris, the most prescribed medicine were corticosteroids, followed by the second most prescribed, drugs which were
immunosuppressants. Additionally rituximab was used in 21 patients. The interval of the disease was 304 days; with an interval of no symptom disease was 415 days for relapsed patients. Similarly, for pemphigoid, the primary treatment used was with corticosteroids, which were also used for the main treatment, in many cases it was combined with other medicines, such as: antihistamines, antibiotics, and immunosuppressants. The average cure time was 148 days, with 32.0% of patients claiming they experienced relapse. Conclusion: To conclude, we observed that corticosteroids, particularly prednisolone, remain still the most important pharmacological treatment for pemphigus vulgaris and pemphigoid. However, rituximab is an effective pharmacological alternative for pemphigus, while the use of clobetasol propionate is increasing and becoming as one of the preferred treatments for pemphigoid. |
| format | Article |
| id | doaj-art-4c6fdeaf56364e85ab5977a58bcafc20 |
| institution | Kabale University |
| issn | 0001-7019 1846-0410 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | University of Zagreb. School of Dental Medicine |
| record_format | Article |
| series | Acta Stomatologica Croatica |
| spelling | doaj-art-4c6fdeaf56364e85ab5977a58bcafc202025-08-20T03:29:35ZengUniversity of Zagreb. School of Dental MedicineActa Stomatologica Croatica0001-70191846-04102025-01-0159219019810.15644/asc59/2/8A 10-Year Observational Study on Treatment Approaches in Pemphigus and PemphigoidCristiana Palmela Pereira0Rui Santos1Leonor Ferreira2Matilde Martins3Ana Rodrigues4Diana Augusto5Paulo Filipe6Faculty of Dental Medicine, University of Lisbon, Portugal; Faculty of Medicine, University of Lisbon, Portugal; University of Zagreb School of Dental Medicine, Zagreb, CroatiaHigher School of Technology and Management, Polytechnic of Leiria, PortugalFaculty of Dental Medicine, University of Lisbon, PortugalFaculty of Dental Medicine, University of Lisbon, PortugalFaculty of Dental Medicine, University of Lisbon, PortugalFaculty of Dental Medicine, University of Lisbon, PortugalFaculty of Medicine, University of Lisbon, PortugalObjectives: The aim of this study was to evaluate epidemiological data on pemphigus vulgaris and pemphigoid, with special focus on characteristics, clinical manifestations, and treatment approaches. Materials and methods: This study includes patients who have been diagnosed with pemphigus vulgaris or pemphigoid at the Dermatology Service of the Santa Maria Local Health Unit between the years 2013 and 2022. The statistical software IBM SPSS® version 29, with Clopper-Pearson 95% confidence intervals (CI) was used for proportions. Results: The total number of patients included in this study is 99 patients with pemphigus vulgaris (49 females, 50 males) and 227 with pemphigoid patients (108 females, 119 males). Patients who have been treated for pemphigus vulgaris, the most prescribed medicine were corticosteroids, followed by the second most prescribed, drugs which were immunosuppressants. Additionally rituximab was used in 21 patients. The interval of the disease was 304 days; with an interval of no symptom disease was 415 days for relapsed patients. Similarly, for pemphigoid, the primary treatment used was with corticosteroids, which were also used for the main treatment, in many cases it was combined with other medicines, such as: antihistamines, antibiotics, and immunosuppressants. The average cure time was 148 days, with 32.0% of patients claiming they experienced relapse. Conclusion: To conclude, we observed that corticosteroids, particularly prednisolone, remain still the most important pharmacological treatment for pemphigus vulgaris and pemphigoid. However, rituximab is an effective pharmacological alternative for pemphigus, while the use of clobetasol propionate is increasing and becoming as one of the preferred treatments for pemphigoid.https://hrcak.srce.hr/file/480583Vesiculobullous Skin DiseasePemphigusPemphigoidDrug TherapyVesiculobullous diseasesPemphigus Vulgaris |
| spellingShingle | Cristiana Palmela Pereira Rui Santos Leonor Ferreira Matilde Martins Ana Rodrigues Diana Augusto Paulo Filipe A 10-Year Observational Study on Treatment Approaches in Pemphigus and Pemphigoid Acta Stomatologica Croatica Vesiculobullous Skin Disease Pemphigus Pemphigoid Drug Therapy Vesiculobullous diseases Pemphigus Vulgaris |
| title | A 10-Year Observational Study on Treatment Approaches in Pemphigus and Pemphigoid |
| title_full | A 10-Year Observational Study on Treatment Approaches in Pemphigus and Pemphigoid |
| title_fullStr | A 10-Year Observational Study on Treatment Approaches in Pemphigus and Pemphigoid |
| title_full_unstemmed | A 10-Year Observational Study on Treatment Approaches in Pemphigus and Pemphigoid |
| title_short | A 10-Year Observational Study on Treatment Approaches in Pemphigus and Pemphigoid |
| title_sort | 10 year observational study on treatment approaches in pemphigus and pemphigoid |
| topic | Vesiculobullous Skin Disease Pemphigus Pemphigoid Drug Therapy Vesiculobullous diseases Pemphigus Vulgaris |
| url | https://hrcak.srce.hr/file/480583 |
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