Cancer-associated macrophage-like cells as a prognostic biomarker in solid tumors
Cancer-associated macrophage-like cells (CAMLs) are myeloid-lineage cells associated with cancer-derived material that are detectable in the blood. In addition to circulating tumor cells, CAMLs are a promising liquid biopsy biomarker which may assist with prognostication for patient stratification a...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
|
| Series: | The Journal of Liquid Biopsy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950195424001413 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850249095092895744 |
|---|---|
| author | Anthony Pirrello Murray Killingsworth Kevin Spring John E.J. Rasko Dannel Yeo |
| author_facet | Anthony Pirrello Murray Killingsworth Kevin Spring John E.J. Rasko Dannel Yeo |
| author_sort | Anthony Pirrello |
| collection | DOAJ |
| description | Cancer-associated macrophage-like cells (CAMLs) are myeloid-lineage cells associated with cancer-derived material that are detectable in the blood. In addition to circulating tumor cells, CAMLs are a promising liquid biopsy biomarker which may assist with prognostication for patient stratification and monitoring response to chemotherapy and radiotherapy in solid tumors. CAMLs have been detected in blood samples from patients with various tumors including lung, pancreas, breast, oesophageal, and colorectal cancers, and to date have not been detected in healthy individuals. However, the optimal method of detection, their origin, function in the circulation, and ultimate utility have not been fully elucidated. This review provides an overview of CAML-related studies and explores their future potential to guide clinical decision-making. |
| format | Article |
| id | doaj-art-4c6d6e555a0e4d1dad4d5d1b88ff5202 |
| institution | OA Journals |
| issn | 2950-1954 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Journal of Liquid Biopsy |
| spelling | doaj-art-4c6d6e555a0e4d1dad4d5d1b88ff52022025-08-20T01:58:34ZengElsevierThe Journal of Liquid Biopsy2950-19542024-12-01610027510.1016/j.jlb.2024.100275Cancer-associated macrophage-like cells as a prognostic biomarker in solid tumorsAnthony Pirrello0Murray Killingsworth1Kevin Spring2John E.J. Rasko3Dannel Yeo4Li Ka Shing Cell and Gene Therapy Program, The University of Sydney, Camperdown, 2050, NSW, Australia; Precision Oncology Laboratory, Centenary Institute, Camperdown, 2050, NSW, AustraliaDepartment of Anatomical Pathology, NSW Health Pathology, Liverpool, 2170, NSW, AustraliaMedical Oncology Group, Liverpool Clinical School, Western Sydney University and Ingham Institute for Applied Medical Research, Liverpool, 2170, NSW, AustraliaLi Ka Shing Cell and Gene Therapy Program, The University of Sydney, Camperdown, 2050, NSW, Australia; Faculty of Medicine and Health, The University of Sydney, Camperdown, 2050, NSW, Australia; Cell and Molecular Therapies, Royal Prince Alfred Hospital, Camperdown, 2050, NSW, AustraliaLi Ka Shing Cell and Gene Therapy Program, The University of Sydney, Camperdown, 2050, NSW, Australia; Precision Oncology Laboratory, Centenary Institute, Camperdown, 2050, NSW, Australia; Faculty of Medicine and Health, The University of Sydney, Camperdown, 2050, NSW, Australia; Cell and Molecular Therapies, Royal Prince Alfred Hospital, Camperdown, 2050, NSW, Australia; Corresponding author. Precision Oncology Laboratory, Centenary Institute, Camperdown, 2050, NSW, Australia.Cancer-associated macrophage-like cells (CAMLs) are myeloid-lineage cells associated with cancer-derived material that are detectable in the blood. In addition to circulating tumor cells, CAMLs are a promising liquid biopsy biomarker which may assist with prognostication for patient stratification and monitoring response to chemotherapy and radiotherapy in solid tumors. CAMLs have been detected in blood samples from patients with various tumors including lung, pancreas, breast, oesophageal, and colorectal cancers, and to date have not been detected in healthy individuals. However, the optimal method of detection, their origin, function in the circulation, and ultimate utility have not been fully elucidated. This review provides an overview of CAML-related studies and explores their future potential to guide clinical decision-making.http://www.sciencedirect.com/science/article/pii/S2950195424001413Liquid biopsyBiomarkerCirculating tumor cellsPrecision medicine |
| spellingShingle | Anthony Pirrello Murray Killingsworth Kevin Spring John E.J. Rasko Dannel Yeo Cancer-associated macrophage-like cells as a prognostic biomarker in solid tumors The Journal of Liquid Biopsy Liquid biopsy Biomarker Circulating tumor cells Precision medicine |
| title | Cancer-associated macrophage-like cells as a prognostic biomarker in solid tumors |
| title_full | Cancer-associated macrophage-like cells as a prognostic biomarker in solid tumors |
| title_fullStr | Cancer-associated macrophage-like cells as a prognostic biomarker in solid tumors |
| title_full_unstemmed | Cancer-associated macrophage-like cells as a prognostic biomarker in solid tumors |
| title_short | Cancer-associated macrophage-like cells as a prognostic biomarker in solid tumors |
| title_sort | cancer associated macrophage like cells as a prognostic biomarker in solid tumors |
| topic | Liquid biopsy Biomarker Circulating tumor cells Precision medicine |
| url | http://www.sciencedirect.com/science/article/pii/S2950195424001413 |
| work_keys_str_mv | AT anthonypirrello cancerassociatedmacrophagelikecellsasaprognosticbiomarkerinsolidtumors AT murraykillingsworth cancerassociatedmacrophagelikecellsasaprognosticbiomarkerinsolidtumors AT kevinspring cancerassociatedmacrophagelikecellsasaprognosticbiomarkerinsolidtumors AT johnejrasko cancerassociatedmacrophagelikecellsasaprognosticbiomarkerinsolidtumors AT dannelyeo cancerassociatedmacrophagelikecellsasaprognosticbiomarkerinsolidtumors |