Diagnostic interval of inflammatory bowel disease in Chinese children and its relationship with growth parameters: a retrospective study
BackgroundDelayed diagnosis of inflammatory bowel disease (IBD) is common in Europe and North America, with limited research in Asia. We aimed to investigate factors influencing delayed diagnosis of IBD in Chinese children and the impact of delayed diagnosis on growth.MethodsThis was a retrospective...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1465694/full |
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| author | Juan Zhou BinRong Chen ZhiCheng Wang Li Liu HongJuan OuYang YanHong Luo WenTing Zhang ChenXi Liu MeiZheng Zhan JiaQi Duan CanLin Li Na Jiang JieYu You HongMei Zhao |
| author_facet | Juan Zhou BinRong Chen ZhiCheng Wang Li Liu HongJuan OuYang YanHong Luo WenTing Zhang ChenXi Liu MeiZheng Zhan JiaQi Duan CanLin Li Na Jiang JieYu You HongMei Zhao |
| author_sort | Juan Zhou |
| collection | DOAJ |
| description | BackgroundDelayed diagnosis of inflammatory bowel disease (IBD) is common in Europe and North America, with limited research in Asia. We aimed to investigate factors influencing delayed diagnosis of IBD in Chinese children and the impact of delayed diagnosis on growth.MethodsThis was a retrospective study. Clinical data on children with IBD were collected through electronic medical records. The diagnostic interval includes the time from symptom onset to hospital admission and admission to diagnosis. Diagnostic delay was defined as the upper quartile of the time interval from the first symptom to the diagnosis of IBD. For the effect on growth indicators, the length of follow-up was at least 3 months from diagnosis.ResultsThis study included 222 children with IBD, predominantly with Crohn's disease (86.0%). Approximately one-quarter of children require more than 366 days to be diagnosed with IBD, primarily due to the extended interval between the onset of initial symptoms and hospital admission. Multivariate logistic regression models showed that fever was associated with a prolonged time interval from first symptom onset to admission and the odds ratio (OR) was 0.45 [95% confidence interval (CI) 0.22–0.94]. Age and bloody stools were associated with prolonged intervals from admission to diagnosis, with ORs of 0.84 (95% CI 0.77–0.92) and 0.36 (95% CI 0.14–0.94), respectively. Delayed diagnosis was associated with height at first admission and follow-up. Children with a delayed diagnosis had a 5.87-fold higher chance of growth retardation upon initial admission compared to children without a delayed diagnosis (95% CI 1.59–24.05). After 15.7 months of follow-up, this elevated risk remained (OR 3.28, 95% CI 1.00–10.50).ConclusionDelayed diagnosis is common in Chinese children with IBD and is associated with persistent height impairment. |
| format | Article |
| id | doaj-art-4c6ca3674de048b58ac981ef8effe82e |
| institution | Kabale University |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-4c6ca3674de048b58ac981ef8effe82e2025-02-05T07:31:46ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-02-011310.3389/fped.2025.14656941465694Diagnostic interval of inflammatory bowel disease in Chinese children and its relationship with growth parameters: a retrospective studyJuan Zhou0BinRong Chen1ZhiCheng Wang2Li Liu3HongJuan OuYang4YanHong Luo5WenTing Zhang6ChenXi Liu7MeiZheng Zhan8JiaQi Duan9CanLin Li10Na Jiang11JieYu You12HongMei Zhao13Department of Gastroenterology and Nutrition, The Affiliated Children’s Hospital of Xiangya School of Medicine, Central South University (Hunan Children’s Hospital), Changsha, Hunan, ChinaThe School of Pediatrics, Hengyang Medical School, University of South China (Hunan Children’s Hospital), Changsha, Hunan, ChinaThe School of Pediatrics, Hengyang Medical School, University of South China (Hunan Children’s Hospital), Changsha, Hunan, ChinaDepartment of Gastroenterology and Nutrition, The Affiliated Children’s Hospital of Xiangya School of Medicine, Central South University (Hunan Children’s Hospital), Changsha, Hunan, ChinaDepartment of Gastroenterology and Nutrition, The Affiliated Children’s Hospital of Xiangya School of Medicine, Central South University (Hunan Children’s Hospital), Changsha, Hunan, ChinaDepartment of Gastroenterology and Nutrition, The Affiliated Children’s Hospital of Xiangya School of Medicine, Central South University (Hunan Children’s Hospital), Changsha, Hunan, ChinaDepartment of Gastroenterology and Nutrition, The Affiliated Children’s Hospital of Xiangya School of Medicine, Central South University (Hunan Children’s Hospital), Changsha, Hunan, ChinaDepartment of Gastroenterology and Nutrition, The Affiliated Children’s Hospital of Xiangya School of Medicine, Central South University (Hunan Children’s Hospital), Changsha, Hunan, ChinaDepartment of Gastroenterology and Nutrition, The Affiliated Children’s Hospital of Xiangya School of Medicine, Central South University (Hunan Children’s Hospital), Changsha, Hunan, ChinaDepartment of Gastroenterology and Nutrition, The Affiliated Children’s Hospital of Xiangya School of Medicine, Central South University (Hunan Children’s Hospital), Changsha, Hunan, ChinaDepartment of Gastroenterology and Nutrition, The Affiliated Children’s Hospital of Xiangya School of Medicine, Central South University (Hunan Children’s Hospital), Changsha, Hunan, ChinaDepartment of Gastroenterology and Nutrition, The Affiliated Children’s Hospital of Xiangya School of Medicine, Central South University (Hunan Children’s Hospital), Changsha, Hunan, ChinaDepartment of Gastroenterology and Nutrition, The Affiliated Children’s Hospital of Xiangya School of Medicine, Central South University (Hunan Children’s Hospital), Changsha, Hunan, ChinaDepartment of Gastroenterology and Nutrition, The Affiliated Children’s Hospital of Xiangya School of Medicine, Central South University (Hunan Children’s Hospital), Changsha, Hunan, ChinaBackgroundDelayed diagnosis of inflammatory bowel disease (IBD) is common in Europe and North America, with limited research in Asia. We aimed to investigate factors influencing delayed diagnosis of IBD in Chinese children and the impact of delayed diagnosis on growth.MethodsThis was a retrospective study. Clinical data on children with IBD were collected through electronic medical records. The diagnostic interval includes the time from symptom onset to hospital admission and admission to diagnosis. Diagnostic delay was defined as the upper quartile of the time interval from the first symptom to the diagnosis of IBD. For the effect on growth indicators, the length of follow-up was at least 3 months from diagnosis.ResultsThis study included 222 children with IBD, predominantly with Crohn's disease (86.0%). Approximately one-quarter of children require more than 366 days to be diagnosed with IBD, primarily due to the extended interval between the onset of initial symptoms and hospital admission. Multivariate logistic regression models showed that fever was associated with a prolonged time interval from first symptom onset to admission and the odds ratio (OR) was 0.45 [95% confidence interval (CI) 0.22–0.94]. Age and bloody stools were associated with prolonged intervals from admission to diagnosis, with ORs of 0.84 (95% CI 0.77–0.92) and 0.36 (95% CI 0.14–0.94), respectively. Delayed diagnosis was associated with height at first admission and follow-up. Children with a delayed diagnosis had a 5.87-fold higher chance of growth retardation upon initial admission compared to children without a delayed diagnosis (95% CI 1.59–24.05). After 15.7 months of follow-up, this elevated risk remained (OR 3.28, 95% CI 1.00–10.50).ConclusionDelayed diagnosis is common in Chinese children with IBD and is associated with persistent height impairment.https://www.frontiersin.org/articles/10.3389/fped.2025.1465694/fullinflammatory bowel diseasechildrendelayed diagnosisCrohn’s diseaseChinese |
| spellingShingle | Juan Zhou BinRong Chen ZhiCheng Wang Li Liu HongJuan OuYang YanHong Luo WenTing Zhang ChenXi Liu MeiZheng Zhan JiaQi Duan CanLin Li Na Jiang JieYu You HongMei Zhao Diagnostic interval of inflammatory bowel disease in Chinese children and its relationship with growth parameters: a retrospective study Frontiers in Pediatrics inflammatory bowel disease children delayed diagnosis Crohn’s disease Chinese |
| title | Diagnostic interval of inflammatory bowel disease in Chinese children and its relationship with growth parameters: a retrospective study |
| title_full | Diagnostic interval of inflammatory bowel disease in Chinese children and its relationship with growth parameters: a retrospective study |
| title_fullStr | Diagnostic interval of inflammatory bowel disease in Chinese children and its relationship with growth parameters: a retrospective study |
| title_full_unstemmed | Diagnostic interval of inflammatory bowel disease in Chinese children and its relationship with growth parameters: a retrospective study |
| title_short | Diagnostic interval of inflammatory bowel disease in Chinese children and its relationship with growth parameters: a retrospective study |
| title_sort | diagnostic interval of inflammatory bowel disease in chinese children and its relationship with growth parameters a retrospective study |
| topic | inflammatory bowel disease children delayed diagnosis Crohn’s disease Chinese |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1465694/full |
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