Utility of Neutrophil-To-Lymphocyte Ratio as Prognostic Marker of Dilated Cardiomyopathy in Children
Background: Dilated cardiomyopathy (DCM) is a frequent form of cardiomyopathy exhibiting systolic and/or diastolic dysfunction, leading to varying degrees of heart failure (HF). The present research was aimed at assessing the utility of neutrophil-to-lymphocyte ratio (NLR) as a prognostic marker of...
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ziauddin University
2025-04-01
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| Series: | Pakistan Journal of Medicine and Dentistry |
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| Online Access: | https://ojs.zu.edu.pk/pjmd/article/view/2702 |
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| author | Sadaf Liaqat Sajid Hussain Sherazi |
| author_facet | Sadaf Liaqat Sajid Hussain Sherazi |
| author_sort | Sadaf Liaqat |
| collection | DOAJ |
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Background: Dilated cardiomyopathy (DCM) is a frequent form of cardiomyopathy exhibiting systolic and/or diastolic dysfunction, leading to varying degrees of heart failure (HF). The present research was aimed at assessing the utility of neutrophil-to-lymphocyte ratio (NLR) as a prognostic marker of DCM in children.
Methods: This cohort study was conducted at the Department of Pediatrics, Rai Teaching Hospital, Sargodha, Pakistan, from October 2022 to September 2024. Seventy-four children of both genders aged up to 18 years with an established diagnosis of DCM and taking treatment for chronic HF were analyzed. Non-probability, consecutive sampling technique was adopted. The NLR for each patient was determined by dividing the total count of neutrophils by the total count of lymphocytes. Children were advised a bi-monthly follow-up and outcomes were recorded after 6 months. The chi-square test was applied to compare categorical data whereas an independent sample t-test was employed for comparing numeric data. P<0.05 was labeled as the level of significance.
Results: In a total of 74 patients, 43 (58.1%) were boys. The mean age was 4.61±4.37 years. By the end of the mandatory period of 6-month follow-up, mortality was reported among 18 (24.3%) children. The need for readmission was significantly higher among children who died (72.2% vs. 26.8%, p=0.030). The mean NRL among children who survived was significantly lower than those who died (1.7±1.9 vs. 4.9±3.8, p<0.001). Among patients who died, oxygen saturation (p=0.046), and LVEF were significantly lower at the time of enrollment when compared to those who survived (p=0.002).
Conclusion: The study demonstrated that NLR may hold promise as a prognostic marker for pediatric DCM. The significant association between lower NLR and survival highlights the potential utility of this simple and cost-effective biomarker in risk stratification and clinical decision-making.
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| format | Article |
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| institution | DOAJ |
| issn | 2313-7371 2308-2593 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | ziauddin University |
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| series | Pakistan Journal of Medicine and Dentistry |
| spelling | doaj-art-4c6bfded727f4c538481ef0b405386dd2025-08-20T03:08:40Zengziauddin UniversityPakistan Journal of Medicine and Dentistry2313-73712308-25932025-04-0114210.36283/ziun-pjmd14-2/017Utility of Neutrophil-To-Lymphocyte Ratio as Prognostic Marker of Dilated Cardiomyopathy in ChildrenSadaf Liaqat0Sajid Hussain Sherazi1Rai Medical College, Sargodha, Pakistan. Niazi Medical and Dental College, Sargodha, Pakistan Background: Dilated cardiomyopathy (DCM) is a frequent form of cardiomyopathy exhibiting systolic and/or diastolic dysfunction, leading to varying degrees of heart failure (HF). The present research was aimed at assessing the utility of neutrophil-to-lymphocyte ratio (NLR) as a prognostic marker of DCM in children. Methods: This cohort study was conducted at the Department of Pediatrics, Rai Teaching Hospital, Sargodha, Pakistan, from October 2022 to September 2024. Seventy-four children of both genders aged up to 18 years with an established diagnosis of DCM and taking treatment for chronic HF were analyzed. Non-probability, consecutive sampling technique was adopted. The NLR for each patient was determined by dividing the total count of neutrophils by the total count of lymphocytes. Children were advised a bi-monthly follow-up and outcomes were recorded after 6 months. The chi-square test was applied to compare categorical data whereas an independent sample t-test was employed for comparing numeric data. P<0.05 was labeled as the level of significance. Results: In a total of 74 patients, 43 (58.1%) were boys. The mean age was 4.61±4.37 years. By the end of the mandatory period of 6-month follow-up, mortality was reported among 18 (24.3%) children. The need for readmission was significantly higher among children who died (72.2% vs. 26.8%, p=0.030). The mean NRL among children who survived was significantly lower than those who died (1.7±1.9 vs. 4.9±3.8, p<0.001). Among patients who died, oxygen saturation (p=0.046), and LVEF were significantly lower at the time of enrollment when compared to those who survived (p=0.002). Conclusion: The study demonstrated that NLR may hold promise as a prognostic marker for pediatric DCM. The significant association between lower NLR and survival highlights the potential utility of this simple and cost-effective biomarker in risk stratification and clinical decision-making. https://ojs.zu.edu.pk/pjmd/article/view/2702Biomarker Dilated Cardiomyopathy Heart Failure Neutrophil Lymphocyte |
| spellingShingle | Sadaf Liaqat Sajid Hussain Sherazi Utility of Neutrophil-To-Lymphocyte Ratio as Prognostic Marker of Dilated Cardiomyopathy in Children Pakistan Journal of Medicine and Dentistry Biomarker Dilated Cardiomyopathy Heart Failure Neutrophil Lymphocyte |
| title | Utility of Neutrophil-To-Lymphocyte Ratio as Prognostic Marker of Dilated Cardiomyopathy in Children |
| title_full | Utility of Neutrophil-To-Lymphocyte Ratio as Prognostic Marker of Dilated Cardiomyopathy in Children |
| title_fullStr | Utility of Neutrophil-To-Lymphocyte Ratio as Prognostic Marker of Dilated Cardiomyopathy in Children |
| title_full_unstemmed | Utility of Neutrophil-To-Lymphocyte Ratio as Prognostic Marker of Dilated Cardiomyopathy in Children |
| title_short | Utility of Neutrophil-To-Lymphocyte Ratio as Prognostic Marker of Dilated Cardiomyopathy in Children |
| title_sort | utility of neutrophil to lymphocyte ratio as prognostic marker of dilated cardiomyopathy in children |
| topic | Biomarker Dilated Cardiomyopathy Heart Failure Neutrophil Lymphocyte |
| url | https://ojs.zu.edu.pk/pjmd/article/view/2702 |
| work_keys_str_mv | AT sadafliaqat utilityofneutrophiltolymphocyteratioasprognosticmarkerofdilatedcardiomyopathyinchildren AT sajidhussainsherazi utilityofneutrophiltolymphocyteratioasprognosticmarkerofdilatedcardiomyopathyinchildren |