Reducing off-target expression of mRNA therapeutics and vaccines in the liver with microRNA binding sites

Reducing off-target expression of mRNA therapeutics and vaccines in the liver with microRNA binding sites

Lipid nanoparticles (LNPs) are often liver tropic, presenting challenges for LNP-delivered mRNA therapeutics intended for other tissues, as off-target expression in the liver may increase side effects and modulate immune responses. To avoid off-target expression in the liver, miR-122 binding sites h...

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Bibliographic Details
Main Authors: Brian J. Parrett, Satoko Yamaoka, Michael A. Barry
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
lipid nanoparticle
mRNA
microRNA
vaccine
de-targeting
miR-122
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050124002183
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