Negative emotion modulates postural tremor variability in Parkinson’s disease: A multimodal EEG and motion sensor study toward behavioral interventions
Background: Despite clinical observations of emotion-tremor interactions in Parkinson’s disease (PD), the neurophysiological mechanisms mediating this relationship remain poorly characterized. Methods: This study employs a multimodal approach integrating 16-channel electroencephalography (EEG) and i...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | IBRO Neuroscience Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266724212500051X |
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| author | Kang Lin Pei Li Pei-zhu Zhang Ping Jin Xin-feng Ma Guang-an Tong Xiao Wen Xue Bai Gong-qiang Wang Yong-zhu Han |
| author_facet | Kang Lin Pei Li Pei-zhu Zhang Ping Jin Xin-feng Ma Guang-an Tong Xiao Wen Xue Bai Gong-qiang Wang Yong-zhu Han |
| author_sort | Kang Lin |
| collection | DOAJ |
| description | Background: Despite clinical observations of emotion-tremor interactions in Parkinson’s disease (PD), the neurophysiological mechanisms mediating this relationship remain poorly characterized. Methods: This study employs a multimodal approach integrating 16-channel electroencephalography (EEG) and inertial motion sensors to investigate emotion-modulated postural tremor dynamics in 20 PD patients and 20 healthy controls (HCs) during standardized video-induced emotional states (positive/neutral/negative). Results: Key findings demonstrate impaired negative emotional processing in PD, manifested as paradoxical increases in subjective valence (pleasure-displeasure ratings) coupled with reduced physiological arousal. Tremor variability predominantly correlated with negative emotional states, showing a negative association with valence scores and positive correlation with arousal levels. EEG analysis identified differential beta-band power modulation in prefrontal (Fp1/Fp2) and temporal (T3/T4) regions during negative emotion processing. These results suggest that emotion-driven tremor fluctuations in PD originate from dysfunctional integration of limbic and motor networks. Conclusion: These findings establish emotion-modulated tremor as a distinct PD phenotype, informing the development of closed-loop biofeedback systems for personalized neuromodulation. |
| format | Article |
| id | doaj-art-4c6899d1faef41b784d2d1cefea324fd |
| institution | OA Journals |
| issn | 2667-2421 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IBRO Neuroscience Reports |
| spelling | doaj-art-4c6899d1faef41b784d2d1cefea324fd2025-08-20T02:06:19ZengElsevierIBRO Neuroscience Reports2667-24212025-06-011866367110.1016/j.ibneur.2025.04.003Negative emotion modulates postural tremor variability in Parkinson’s disease: A multimodal EEG and motion sensor study toward behavioral interventionsKang Lin0Pei Li1Pei-zhu Zhang2Ping Jin3Xin-feng Ma4Guang-an Tong5Xiao Wen6Xue Bai7Gong-qiang Wang8Yong-zhu Han9Affiliated Hospital of Institute of Neurology, Anhui University of Traditional Chinese Medicine, Hefei, ChinaInstitute of Neurology, Anhui University of Traditional Chinese Medicine, Hefei, China; Graduate School, Anhui University of Traditional Chinese Medicine, Hefei, ChinaInstitute of Neurology, Anhui University of Traditional Chinese Medicine, Hefei, China; Graduate School, Anhui University of Traditional Chinese Medicine, Hefei, ChinaAffiliated Hospital of Institute of Neurology, Anhui University of Traditional Chinese Medicine, Hefei, ChinaAffiliated Hospital of Institute of Neurology, Anhui University of Traditional Chinese Medicine, Hefei, ChinaAffiliated Hospital of Institute of Neurology, Anhui University of Traditional Chinese Medicine, Hefei, ChinaInstitute of Neurology, Anhui University of Traditional Chinese Medicine, Hefei, China; Graduate School, Anhui University of Traditional Chinese Medicine, Hefei, ChinaInstitute of Neurology, Anhui University of Traditional Chinese Medicine, Hefei, China; Graduate School, Anhui University of Traditional Chinese Medicine, Hefei, ChinaAffiliated Hospital of Institute of Neurology, Anhui University of Traditional Chinese Medicine, Hefei, China; Institute of Neurology, Anhui University of Traditional Chinese Medicine, Hefei, China; Correspondence to: No. 357 Changjiang Middle Road, Hefei 230061, China.Affiliated Hospital of Institute of Neurology, Anhui University of Traditional Chinese Medicine, Hefei, China; Institute of Neurology, Anhui University of Traditional Chinese Medicine, Hefei, ChinaBackground: Despite clinical observations of emotion-tremor interactions in Parkinson’s disease (PD), the neurophysiological mechanisms mediating this relationship remain poorly characterized. Methods: This study employs a multimodal approach integrating 16-channel electroencephalography (EEG) and inertial motion sensors to investigate emotion-modulated postural tremor dynamics in 20 PD patients and 20 healthy controls (HCs) during standardized video-induced emotional states (positive/neutral/negative). Results: Key findings demonstrate impaired negative emotional processing in PD, manifested as paradoxical increases in subjective valence (pleasure-displeasure ratings) coupled with reduced physiological arousal. Tremor variability predominantly correlated with negative emotional states, showing a negative association with valence scores and positive correlation with arousal levels. EEG analysis identified differential beta-band power modulation in prefrontal (Fp1/Fp2) and temporal (T3/T4) regions during negative emotion processing. These results suggest that emotion-driven tremor fluctuations in PD originate from dysfunctional integration of limbic and motor networks. Conclusion: These findings establish emotion-modulated tremor as a distinct PD phenotype, informing the development of closed-loop biofeedback systems for personalized neuromodulation.http://www.sciencedirect.com/science/article/pii/S266724212500051XParkinson’s diseasePostural tremorEmotion regulationBeta oscillationsWearable sensors |
| spellingShingle | Kang Lin Pei Li Pei-zhu Zhang Ping Jin Xin-feng Ma Guang-an Tong Xiao Wen Xue Bai Gong-qiang Wang Yong-zhu Han Negative emotion modulates postural tremor variability in Parkinson’s disease: A multimodal EEG and motion sensor study toward behavioral interventions IBRO Neuroscience Reports Parkinson’s disease Postural tremor Emotion regulation Beta oscillations Wearable sensors |
| title | Negative emotion modulates postural tremor variability in Parkinson’s disease: A multimodal EEG and motion sensor study toward behavioral interventions |
| title_full | Negative emotion modulates postural tremor variability in Parkinson’s disease: A multimodal EEG and motion sensor study toward behavioral interventions |
| title_fullStr | Negative emotion modulates postural tremor variability in Parkinson’s disease: A multimodal EEG and motion sensor study toward behavioral interventions |
| title_full_unstemmed | Negative emotion modulates postural tremor variability in Parkinson’s disease: A multimodal EEG and motion sensor study toward behavioral interventions |
| title_short | Negative emotion modulates postural tremor variability in Parkinson’s disease: A multimodal EEG and motion sensor study toward behavioral interventions |
| title_sort | negative emotion modulates postural tremor variability in parkinson s disease a multimodal eeg and motion sensor study toward behavioral interventions |
| topic | Parkinson’s disease Postural tremor Emotion regulation Beta oscillations Wearable sensors |
| url | http://www.sciencedirect.com/science/article/pii/S266724212500051X |
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