Post COVID-19 syndrome and new onset diseases: a prospective observational study
Introduction: The National Institute of Health and Care Excellence (NICE) has defined the terms, ‘acute coronavirus disease 2019’ (COVID-19), ‘ongoing symptomatic COVID-19’ and ‘post-COVID-19 syndrome’, with the latter two described as having persistent symptoms after the onset of COVID-19 symptoms...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer – Medknow Publications
2025-07-01
|
| Series: | Singapore Medical Journal |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/singaporemedj.SMJ-2022-055 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849230785839628288 |
|---|---|
| author | Nitin Sinha Mahinder Pal Singh Chawla Desh Deepak Amit Suri Piyush Jain Ankit Agarwal Manoj Kumar Bhakhar |
| author_facet | Nitin Sinha Mahinder Pal Singh Chawla Desh Deepak Amit Suri Piyush Jain Ankit Agarwal Manoj Kumar Bhakhar |
| author_sort | Nitin Sinha |
| collection | DOAJ |
| description | Introduction:
The National Institute of Health and Care Excellence (NICE) has defined the terms, ‘acute coronavirus disease 2019’ (COVID-19), ‘ongoing symptomatic COVID-19’ and ‘post-COVID-19 syndrome’, with the latter two described as having persistent symptoms after the onset of COVID-19 symptoms for 4–12 weeks and >12 weeks, respectively. Persistent symptoms can either be due to the after-effects of COVID-19 or new-onset diseases after acute COVID-19. All symptoms observed beyond 4 weeks after the onset of COVID-19 need not be present at the time of onset. Previous studies on persistent post-COVID-19 symptoms have not mentioned new-onset diseases after acute COVID-19, and only a select few studies have discussed such new-onset symptoms.
Methods:
Ninety-five patients who attended the post-COVID-19 clinic completed the requisite follow-up till 16 weeks after COVID-19 symptom onset. Data was recorded on a predesigned proforma. Necessary investigations were conducted to rule out any other cause of persistent symptoms.
Results:
Fatigue (62.1%), breathlessness (50.5%) and cough (27.4%) were the most common symptoms present beyond 4 weeks after the onset of COVID-19 symptoms. Forty-nine (51.57%) patients developed post-COVID-19 syndrome — their severity of symptoms (odds ratio [OR] 17.77) and longer duration of hospital stay (OR 1.095) during acute disease were significantly associated with the development of post-COVID-19 syndrome. During follow-up, 25 patients developed new-onset symptoms, such as diabetes mellitus, hypertension and idiopathic tachycardia.
Conclusion:
Patients can have persistent symptoms, new-onset symptoms and new-onset diseases after recovery from acute COVID-19. |
| format | Article |
| id | doaj-art-4c6434a93b4b403f83aedf591852c33a |
| institution | Kabale University |
| issn | 0037-5675 2737-5935 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wolters Kluwer – Medknow Publications |
| record_format | Article |
| series | Singapore Medical Journal |
| spelling | doaj-art-4c6434a93b4b403f83aedf591852c33a2025-08-21T05:55:08ZengWolters Kluwer – Medknow PublicationsSingapore Medical Journal0037-56752737-59352025-07-0166735436110.4103/singaporemedj.SMJ-2022-055Post COVID-19 syndrome and new onset diseases: a prospective observational studyNitin SinhaMahinder Pal Singh ChawlaDesh DeepakAmit SuriPiyush JainAnkit AgarwalManoj Kumar BhakharIntroduction: The National Institute of Health and Care Excellence (NICE) has defined the terms, ‘acute coronavirus disease 2019’ (COVID-19), ‘ongoing symptomatic COVID-19’ and ‘post-COVID-19 syndrome’, with the latter two described as having persistent symptoms after the onset of COVID-19 symptoms for 4–12 weeks and >12 weeks, respectively. Persistent symptoms can either be due to the after-effects of COVID-19 or new-onset diseases after acute COVID-19. All symptoms observed beyond 4 weeks after the onset of COVID-19 need not be present at the time of onset. Previous studies on persistent post-COVID-19 symptoms have not mentioned new-onset diseases after acute COVID-19, and only a select few studies have discussed such new-onset symptoms. Methods: Ninety-five patients who attended the post-COVID-19 clinic completed the requisite follow-up till 16 weeks after COVID-19 symptom onset. Data was recorded on a predesigned proforma. Necessary investigations were conducted to rule out any other cause of persistent symptoms. Results: Fatigue (62.1%), breathlessness (50.5%) and cough (27.4%) were the most common symptoms present beyond 4 weeks after the onset of COVID-19 symptoms. Forty-nine (51.57%) patients developed post-COVID-19 syndrome — their severity of symptoms (odds ratio [OR] 17.77) and longer duration of hospital stay (OR 1.095) during acute disease were significantly associated with the development of post-COVID-19 syndrome. During follow-up, 25 patients developed new-onset symptoms, such as diabetes mellitus, hypertension and idiopathic tachycardia. Conclusion: Patients can have persistent symptoms, new-onset symptoms and new-onset diseases after recovery from acute COVID-19.https://journals.lww.com/10.4103/singaporemedj.SMJ-2022-055new-onset diseases post-covid-19ongoing symptomatic covid-19post-covid-19 sequelaepost-covid-19 syndromepredictors of post-covid-19 syndrome |
| spellingShingle | Nitin Sinha Mahinder Pal Singh Chawla Desh Deepak Amit Suri Piyush Jain Ankit Agarwal Manoj Kumar Bhakhar Post COVID-19 syndrome and new onset diseases: a prospective observational study Singapore Medical Journal new-onset diseases post-covid-19 ongoing symptomatic covid-19 post-covid-19 sequelae post-covid-19 syndrome predictors of post-covid-19 syndrome |
| title | Post COVID-19 syndrome and new onset diseases: a prospective observational study |
| title_full | Post COVID-19 syndrome and new onset diseases: a prospective observational study |
| title_fullStr | Post COVID-19 syndrome and new onset diseases: a prospective observational study |
| title_full_unstemmed | Post COVID-19 syndrome and new onset diseases: a prospective observational study |
| title_short | Post COVID-19 syndrome and new onset diseases: a prospective observational study |
| title_sort | post covid 19 syndrome and new onset diseases a prospective observational study |
| topic | new-onset diseases post-covid-19 ongoing symptomatic covid-19 post-covid-19 sequelae post-covid-19 syndrome predictors of post-covid-19 syndrome |
| url | https://journals.lww.com/10.4103/singaporemedj.SMJ-2022-055 |
| work_keys_str_mv | AT nitinsinha postcovid19syndromeandnewonsetdiseasesaprospectiveobservationalstudy AT mahinderpalsinghchawla postcovid19syndromeandnewonsetdiseasesaprospectiveobservationalstudy AT deshdeepak postcovid19syndromeandnewonsetdiseasesaprospectiveobservationalstudy AT amitsuri postcovid19syndromeandnewonsetdiseasesaprospectiveobservationalstudy AT piyushjain postcovid19syndromeandnewonsetdiseasesaprospectiveobservationalstudy AT ankitagarwal postcovid19syndromeandnewonsetdiseasesaprospectiveobservationalstudy AT manojkumarbhakhar postcovid19syndromeandnewonsetdiseasesaprospectiveobservationalstudy |