The investigation of apoptosis-related genes in periodontitis
Abstract Objectives This study aims at determination of the roles of five apoptosis-related genes, namely CASP2, CASP8, BCL2, HULC and PVT1 in the pathoetiology of periodontitis via measurement of their expressions in both peripheral blood and tissues of affected persons. Results CASP2 was over-expr...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-05-01
|
| Series: | BMC Research Notes |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13104-025-07274-4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850271892214120448 |
|---|---|
| author | Arezou Sayad Fatemeh Hashemian Leila Gholami Masoud Jamali Elham Badrlou Saba Sadeghpour Naghme Nazer Sheyda Khalilian Soudeh Ghafouri-Fard |
| author_facet | Arezou Sayad Fatemeh Hashemian Leila Gholami Masoud Jamali Elham Badrlou Saba Sadeghpour Naghme Nazer Sheyda Khalilian Soudeh Ghafouri-Fard |
| author_sort | Arezou Sayad |
| collection | DOAJ |
| description | Abstract Objectives This study aims at determination of the roles of five apoptosis-related genes, namely CASP2, CASP8, BCL2, HULC and PVT1 in the pathoetiology of periodontitis via measurement of their expressions in both peripheral blood and tissues of affected persons. Results CASP2 was over-expressed in gingiva of patients compared with healthy subjects (RME = 24.56, P < 0.001), and in both affected females and males (RME = 30.53, P = 0.03 and RME = 20.59, P = 0.01, respectively). BCL2 was higher in affected tissues compared with controls (RME = 32.28, P < 0.001) and in affected tissues of males versus controls (RME = 69.03, P < 0.001). Finally, HULC had lower level in the blood of patients (RME = 0.21, P = 0.01) and in the blood of female patients compared with normal females (RME = 0.15, P = 0.01). Other comparisons yielded no significant results. BCL2 and CASP2 had the highest diagnostic values for separation of diseased gingival tissues from normal ones. HULC has the best values in the distinction of blood samples of affected persons from control persons. Combination of transcript levels of CASP2, CASP8, BCL2, HULC and PVT1 changed AUC to 0.84 and 0.72 in tissues and blood samples, respectively. To conclude, these genes might be regarded as putative contributors in the pathophysiology of periodontitis. |
| format | Article |
| id | doaj-art-4c5e85ebe4194023a7865c1bb72cae3d |
| institution | OA Journals |
| issn | 1756-0500 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj-art-4c5e85ebe4194023a7865c1bb72cae3d2025-08-20T01:52:03ZengBMCBMC Research Notes1756-05002025-05-011811810.1186/s13104-025-07274-4The investigation of apoptosis-related genes in periodontitisArezou Sayad0Fatemeh Hashemian1Leila Gholami2Masoud Jamali3Elham Badrlou4Saba Sadeghpour5Naghme Nazer6Sheyda Khalilian7Soudeh Ghafouri-Fard8Department of Medical Genetics, Shahid Beheshti University of Medical SciencesDepartment of Medical Genetics, Shahid Beheshti University of Medical SciencesDepartment of Periodontics, Dental Research Center, Hamadan University of Medical SciencesSarem HospitalDepartment of Medical Genetics, Shahid Beheshti University of Medical SciencesDepartment of Medical Genetics, Shahid Beheshti University of Medical SciencesDepartment of Electrical Engineering, Sharif University of TechnologyDepartment of Medical Genetics, Shahid Beheshti University of Medical SciencesDental Research Center, Research Institute for Dental Sciences, Dental School, Shahid Beheshti University of Medical SciencesAbstract Objectives This study aims at determination of the roles of five apoptosis-related genes, namely CASP2, CASP8, BCL2, HULC and PVT1 in the pathoetiology of periodontitis via measurement of their expressions in both peripheral blood and tissues of affected persons. Results CASP2 was over-expressed in gingiva of patients compared with healthy subjects (RME = 24.56, P < 0.001), and in both affected females and males (RME = 30.53, P = 0.03 and RME = 20.59, P = 0.01, respectively). BCL2 was higher in affected tissues compared with controls (RME = 32.28, P < 0.001) and in affected tissues of males versus controls (RME = 69.03, P < 0.001). Finally, HULC had lower level in the blood of patients (RME = 0.21, P = 0.01) and in the blood of female patients compared with normal females (RME = 0.15, P = 0.01). Other comparisons yielded no significant results. BCL2 and CASP2 had the highest diagnostic values for separation of diseased gingival tissues from normal ones. HULC has the best values in the distinction of blood samples of affected persons from control persons. Combination of transcript levels of CASP2, CASP8, BCL2, HULC and PVT1 changed AUC to 0.84 and 0.72 in tissues and blood samples, respectively. To conclude, these genes might be regarded as putative contributors in the pathophysiology of periodontitis.https://doi.org/10.1186/s13104-025-07274-4PeriodontitisB-Cell CLL/Lymphoma 2Caspase2Caspase 8HULCPvt1 |
| spellingShingle | Arezou Sayad Fatemeh Hashemian Leila Gholami Masoud Jamali Elham Badrlou Saba Sadeghpour Naghme Nazer Sheyda Khalilian Soudeh Ghafouri-Fard The investigation of apoptosis-related genes in periodontitis BMC Research Notes Periodontitis B-Cell CLL/Lymphoma 2 Caspase2 Caspase 8 HULC Pvt1 |
| title | The investigation of apoptosis-related genes in periodontitis |
| title_full | The investigation of apoptosis-related genes in periodontitis |
| title_fullStr | The investigation of apoptosis-related genes in periodontitis |
| title_full_unstemmed | The investigation of apoptosis-related genes in periodontitis |
| title_short | The investigation of apoptosis-related genes in periodontitis |
| title_sort | investigation of apoptosis related genes in periodontitis |
| topic | Periodontitis B-Cell CLL/Lymphoma 2 Caspase2 Caspase 8 HULC Pvt1 |
| url | https://doi.org/10.1186/s13104-025-07274-4 |
| work_keys_str_mv | AT arezousayad theinvestigationofapoptosisrelatedgenesinperiodontitis AT fatemehhashemian theinvestigationofapoptosisrelatedgenesinperiodontitis AT leilagholami theinvestigationofapoptosisrelatedgenesinperiodontitis AT masoudjamali theinvestigationofapoptosisrelatedgenesinperiodontitis AT elhambadrlou theinvestigationofapoptosisrelatedgenesinperiodontitis AT sabasadeghpour theinvestigationofapoptosisrelatedgenesinperiodontitis AT naghmenazer theinvestigationofapoptosisrelatedgenesinperiodontitis AT sheydakhalilian theinvestigationofapoptosisrelatedgenesinperiodontitis AT soudehghafourifard theinvestigationofapoptosisrelatedgenesinperiodontitis AT arezousayad investigationofapoptosisrelatedgenesinperiodontitis AT fatemehhashemian investigationofapoptosisrelatedgenesinperiodontitis AT leilagholami investigationofapoptosisrelatedgenesinperiodontitis AT masoudjamali investigationofapoptosisrelatedgenesinperiodontitis AT elhambadrlou investigationofapoptosisrelatedgenesinperiodontitis AT sabasadeghpour investigationofapoptosisrelatedgenesinperiodontitis AT naghmenazer investigationofapoptosisrelatedgenesinperiodontitis AT sheydakhalilian investigationofapoptosisrelatedgenesinperiodontitis AT soudehghafourifard investigationofapoptosisrelatedgenesinperiodontitis |