The secreted triose phosphate isomerase of Brugia malayi is required to sustain microfilaria production in vivo.
Human lymphatic filariasis is a major tropical disease transmitted through mosquito vectors which take up microfilarial larvae from the blood of infected subjects. Microfilariae are produced by long-lived adult parasites, which also release a suite of excretory-secretory products that have recently...
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| Main Authors: | James P Hewitson, Dominik Rückerl, Yvonne Harcus, Janice Murray, Lauren M Webb, Simon A Babayan, Judith E Allen, Agnes Kurniawan, Rick M Maizels |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-02-01
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| Series: | PLoS Pathogens |
| Online Access: | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003930&type=printable |
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