Evaluating the influence of parental atopy on the effectiveness of a maternal dairy-free diet in alleviating infantile colic: a before-and-after study
Abstract Background Infantile Colic (IC) poses a significant challenge for parents as it manifests through repeated and extended episodes of fussiness, crying, or irritability occurring before the age of 5 months. The precise cause of IC is currently unknown. The association between IC, a family his...
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2024-11-01
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| Series: | BMC Pediatrics |
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| Online Access: | https://doi.org/10.1186/s12887-024-05175-2 |
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| author | Roghaye Ostadi Ali Pourvali Amin Tajerian Saeed Alinezhad Asghar Lotfi Javad Javaheri |
| author_facet | Roghaye Ostadi Ali Pourvali Amin Tajerian Saeed Alinezhad Asghar Lotfi Javad Javaheri |
| author_sort | Roghaye Ostadi |
| collection | DOAJ |
| description | Abstract Background Infantile Colic (IC) poses a significant challenge for parents as it manifests through repeated and extended episodes of fussiness, crying, or irritability occurring before the age of 5 months. The precise cause of IC is currently unknown. The association between IC, a family history of atopy, and the development of individual atopy in the future remains uncertain, given conflicting findings from prior studies. Objectives This study aimed to investigate the impact of parental atopy on IC severity and the effectiveness of the mother’s hypoallergenic Dairy-Free Diet in alleviating pain in infants with colic. Methods This non-randomized trial conducted at Amirkabir Hospital in Arak, Iran, from January 2023 to October 2023, involving 206 eligible IC patients non-randomly assigned to two groups based on parental atopy history. Breastfed infants were prescribed a dairy-free diet, involving the removal of dairy products from the mother’s diet. Pain severity was assessed using the FLACC scale at baseline and after one-month of intervention. Results The research initially involved 206 subjects with an average age of 28.77 ± 9.99 days, evenly distributed based on parental atopy history. However, there was a 28.6% loss to follow-up, resulting in a final analyzed population of 147 individuals. The intervention, a maternal dairy-free diet, demonstrated a significant reduction in pain symptoms within both groups and overall (P = 0.001), with no significant difference in efficacy between infants with and without parental atopy history (P = 0.219). Parental history of atopy did not exhibit a significant association with colic pain severity (P = 0.404). The study revealed that the impact of the diet on colic severity varied, with more pronounced effects observed in cases of severe and moderate colic compared to mild cases. Conclusions Adopting a Dairy-Free Diet significantly reduced colic symptoms, irrespective of parental atopy history. The severity of colic appears unrelated to parental atopy, and the observed improvement with a Dairy-Free diet is potentially attributed to milk intolerance rather than milk allergy. |
| format | Article |
| id | doaj-art-4c4e743c045347efbed6cc4be9a344aa |
| institution | Kabale University |
| issn | 1471-2431 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj-art-4c4e743c045347efbed6cc4be9a344aa2024-11-10T12:42:55ZengBMCBMC Pediatrics1471-24312024-11-012411710.1186/s12887-024-05175-2Evaluating the influence of parental atopy on the effectiveness of a maternal dairy-free diet in alleviating infantile colic: a before-and-after studyRoghaye Ostadi0Ali Pourvali1Amin Tajerian2Saeed Alinezhad3Asghar Lotfi4Javad Javaheri5School of Medicine, Arak University of Medical SciencesDepartment of Pediatrics, School of Medicine, Arak University of Medical SciencesSchool of Medicine, Arak University of Medical SciencesDepartment of Pediatrics, School of Medicine, Arak University of Medical SciencesDepartment of Microbiology and Immunology, Arak University of Medical SciencesSchool of Medicine, Arak University of Medical SciencesAbstract Background Infantile Colic (IC) poses a significant challenge for parents as it manifests through repeated and extended episodes of fussiness, crying, or irritability occurring before the age of 5 months. The precise cause of IC is currently unknown. The association between IC, a family history of atopy, and the development of individual atopy in the future remains uncertain, given conflicting findings from prior studies. Objectives This study aimed to investigate the impact of parental atopy on IC severity and the effectiveness of the mother’s hypoallergenic Dairy-Free Diet in alleviating pain in infants with colic. Methods This non-randomized trial conducted at Amirkabir Hospital in Arak, Iran, from January 2023 to October 2023, involving 206 eligible IC patients non-randomly assigned to two groups based on parental atopy history. Breastfed infants were prescribed a dairy-free diet, involving the removal of dairy products from the mother’s diet. Pain severity was assessed using the FLACC scale at baseline and after one-month of intervention. Results The research initially involved 206 subjects with an average age of 28.77 ± 9.99 days, evenly distributed based on parental atopy history. However, there was a 28.6% loss to follow-up, resulting in a final analyzed population of 147 individuals. The intervention, a maternal dairy-free diet, demonstrated a significant reduction in pain symptoms within both groups and overall (P = 0.001), with no significant difference in efficacy between infants with and without parental atopy history (P = 0.219). Parental history of atopy did not exhibit a significant association with colic pain severity (P = 0.404). The study revealed that the impact of the diet on colic severity varied, with more pronounced effects observed in cases of severe and moderate colic compared to mild cases. Conclusions Adopting a Dairy-Free Diet significantly reduced colic symptoms, irrespective of parental atopy history. The severity of colic appears unrelated to parental atopy, and the observed improvement with a Dairy-Free diet is potentially attributed to milk intolerance rather than milk allergy.https://doi.org/10.1186/s12887-024-05175-2Parental atopyInfantile colicMilk intoleranceHypoallergenic diet |
| spellingShingle | Roghaye Ostadi Ali Pourvali Amin Tajerian Saeed Alinezhad Asghar Lotfi Javad Javaheri Evaluating the influence of parental atopy on the effectiveness of a maternal dairy-free diet in alleviating infantile colic: a before-and-after study BMC Pediatrics Parental atopy Infantile colic Milk intolerance Hypoallergenic diet |
| title | Evaluating the influence of parental atopy on the effectiveness of a maternal dairy-free diet in alleviating infantile colic: a before-and-after study |
| title_full | Evaluating the influence of parental atopy on the effectiveness of a maternal dairy-free diet in alleviating infantile colic: a before-and-after study |
| title_fullStr | Evaluating the influence of parental atopy on the effectiveness of a maternal dairy-free diet in alleviating infantile colic: a before-and-after study |
| title_full_unstemmed | Evaluating the influence of parental atopy on the effectiveness of a maternal dairy-free diet in alleviating infantile colic: a before-and-after study |
| title_short | Evaluating the influence of parental atopy on the effectiveness of a maternal dairy-free diet in alleviating infantile colic: a before-and-after study |
| title_sort | evaluating the influence of parental atopy on the effectiveness of a maternal dairy free diet in alleviating infantile colic a before and after study |
| topic | Parental atopy Infantile colic Milk intolerance Hypoallergenic diet |
| url | https://doi.org/10.1186/s12887-024-05175-2 |
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