In Vitro Sustained Release Study of Gallic Acid Coated with Magnetite-PEG and Magnetite-PVA for Drug Delivery System
The efficacy of two nanocarriers polyethylene glycol and polyvinyl alcohol magnetic nanoparticles coated with gallic acid (GA) was accomplished via X-ray diffraction, infrared spectroscopy, magnetic measurements, thermal analysis, and TEM. X-ray diffraction and TEM results showed that Fe3O4 nanopart...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/416354 |
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| author | Dena Dorniani Aminu Umar Kura Samer Hasan Hussein-Al-Ali Mohd Zobir Bin Hussein Sharida Fakurazi Abdul Halim Shaari Zalinah Ahmad |
| author_facet | Dena Dorniani Aminu Umar Kura Samer Hasan Hussein-Al-Ali Mohd Zobir Bin Hussein Sharida Fakurazi Abdul Halim Shaari Zalinah Ahmad |
| author_sort | Dena Dorniani |
| collection | DOAJ |
| description | The efficacy of two nanocarriers polyethylene glycol and polyvinyl alcohol magnetic nanoparticles coated with gallic acid (GA) was accomplished via X-ray diffraction, infrared spectroscopy, magnetic measurements, thermal analysis, and TEM. X-ray diffraction and TEM results showed that Fe3O4 nanoparticles were pure iron oxide having spherical shape with the average diameter of 9 nm, compared with 31 nm and 35 nm after coating with polyethylene glycol-GA (FPEGG) and polyvinyl alcohol-GA (FPVAG), respectively. Thermogravimetric analyses proved that after coating the thermal stability was markedly enhanced. Magnetic measurements and Fourier transform infrared (FTIR) revealed that superparamagnetic iron oxide nanoparticles could be successfully coated with two polymers (PEG and PVA) and gallic acid as an active drug. Release behavior of gallic acid from two nanocomposites showed that FPEGG and FPVAG nanocomposites were found to be sustained and governed by pseudo-second-order kinetics. Anticancer activity of the two nanocomposites shows that the FPEGG demonstrated higher anticancer effect on the breast cancer cell lines in almost all concentrations tested compared to FPVAG. |
| format | Article |
| id | doaj-art-4c4cbb4e336d479abd4794c5cb37b0d1 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-4c4cbb4e336d479abd4794c5cb37b0d12025-02-03T06:05:52ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/416354416354In Vitro Sustained Release Study of Gallic Acid Coated with Magnetite-PEG and Magnetite-PVA for Drug Delivery SystemDena Dorniani0Aminu Umar Kura1Samer Hasan Hussein-Al-Ali2Mohd Zobir Bin Hussein3Sharida Fakurazi4Abdul Halim Shaari5Zalinah Ahmad6Materials Synthesis and Characterization Laboratory (MSCL), Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, 43400, Selangor, MalaysiaVaccines and Immunotherapeutics Laboratory (IBS), Universiti Putra Malaysia, 43400, Selangor, MalaysiaLaboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400, Selangor, MalaysiaMaterials Synthesis and Characterization Laboratory (MSCL), Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, 43400, Selangor, MalaysiaVaccines and Immunotherapeutics Laboratory (IBS), Universiti Putra Malaysia, 43400, Selangor, MalaysiaPhysics Department, Faculty of Science, Universiti Putra Malaysia, 43400, Selangor, MalaysiaVaccines and Immunotherapeutics Laboratory (IBS), Universiti Putra Malaysia, 43400, Selangor, MalaysiaThe efficacy of two nanocarriers polyethylene glycol and polyvinyl alcohol magnetic nanoparticles coated with gallic acid (GA) was accomplished via X-ray diffraction, infrared spectroscopy, magnetic measurements, thermal analysis, and TEM. X-ray diffraction and TEM results showed that Fe3O4 nanoparticles were pure iron oxide having spherical shape with the average diameter of 9 nm, compared with 31 nm and 35 nm after coating with polyethylene glycol-GA (FPEGG) and polyvinyl alcohol-GA (FPVAG), respectively. Thermogravimetric analyses proved that after coating the thermal stability was markedly enhanced. Magnetic measurements and Fourier transform infrared (FTIR) revealed that superparamagnetic iron oxide nanoparticles could be successfully coated with two polymers (PEG and PVA) and gallic acid as an active drug. Release behavior of gallic acid from two nanocomposites showed that FPEGG and FPVAG nanocomposites were found to be sustained and governed by pseudo-second-order kinetics. Anticancer activity of the two nanocomposites shows that the FPEGG demonstrated higher anticancer effect on the breast cancer cell lines in almost all concentrations tested compared to FPVAG.http://dx.doi.org/10.1155/2014/416354 |
| spellingShingle | Dena Dorniani Aminu Umar Kura Samer Hasan Hussein-Al-Ali Mohd Zobir Bin Hussein Sharida Fakurazi Abdul Halim Shaari Zalinah Ahmad In Vitro Sustained Release Study of Gallic Acid Coated with Magnetite-PEG and Magnetite-PVA for Drug Delivery System The Scientific World Journal |
| title | In Vitro Sustained Release Study of Gallic Acid Coated with Magnetite-PEG and Magnetite-PVA for Drug Delivery System |
| title_full | In Vitro Sustained Release Study of Gallic Acid Coated with Magnetite-PEG and Magnetite-PVA for Drug Delivery System |
| title_fullStr | In Vitro Sustained Release Study of Gallic Acid Coated with Magnetite-PEG and Magnetite-PVA for Drug Delivery System |
| title_full_unstemmed | In Vitro Sustained Release Study of Gallic Acid Coated with Magnetite-PEG and Magnetite-PVA for Drug Delivery System |
| title_short | In Vitro Sustained Release Study of Gallic Acid Coated with Magnetite-PEG and Magnetite-PVA for Drug Delivery System |
| title_sort | in vitro sustained release study of gallic acid coated with magnetite peg and magnetite pva for drug delivery system |
| url | http://dx.doi.org/10.1155/2014/416354 |
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