Longitudinal Raman Spectroscopic Observation of Skin Biochemical Changes due to Chemotherapeutic Treatment for Breast Cancer in Small Animal Model
The cancer field effect (CFE) has been highlighted as one of indirect indications for tissue variations that are insensitive to conventional diagnostic techniques. In this research, we had a hypothesis that chemotherapy for breast cancer would affect skin biochemical compositions that would be refle...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Spectroscopy |
| Online Access: | http://dx.doi.org/10.1155/2017/3595078 |
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| author | Myeongsu Seong NoSoung Myoung Songhyun Lee Hyeryun Jeong Sang-Youp Yim Jae Gwan Kim |
| author_facet | Myeongsu Seong NoSoung Myoung Songhyun Lee Hyeryun Jeong Sang-Youp Yim Jae Gwan Kim |
| author_sort | Myeongsu Seong |
| collection | DOAJ |
| description | The cancer field effect (CFE) has been highlighted as one of indirect indications for tissue variations that are insensitive to conventional diagnostic techniques. In this research, we had a hypothesis that chemotherapy for breast cancer would affect skin biochemical compositions that would be reflected by Raman spectral changes. We used a fiber-optic probe-based Raman spectroscopy to perform preliminary animal experiments to validate the hypothesis. Firstly, we verified the probing depth of the fiber-optic probe (~800 μm) using a simple intravenous fat emulsion-filled phantom having a silicon wafer at the bottom inside a cuvette. Then, we obtained Raman spectra during breast cancer treatment by chemotherapy from a small animal model in longitudinal manner. Our results showed that the treatment causes variations of biochemical compositions in the skin. For further validation, the Raman spectra will have to be collected from more populations and spectra will need to be compared with immunohistochemistry of the breast tissue. |
| format | Article |
| id | doaj-art-4c4b1624714648dbaa58931d910a5001 |
| institution | Kabale University |
| issn | 2314-4920 2314-4939 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Spectroscopy |
| spelling | doaj-art-4c4b1624714648dbaa58931d910a50012025-02-03T01:27:38ZengWileyJournal of Spectroscopy2314-49202314-49392017-01-01201710.1155/2017/35950783595078Longitudinal Raman Spectroscopic Observation of Skin Biochemical Changes due to Chemotherapeutic Treatment for Breast Cancer in Small Animal ModelMyeongsu Seong0NoSoung Myoung1Songhyun Lee2Hyeryun Jeong3Sang-Youp Yim4Jae Gwan Kim5Department of Biomedical Science and Engineering, Institute of Integrated Technology, Gwangju Institute of Science and Technology, 123 Cheomdan Gwagiro, Bukgu, Gwangju 61005, Republic of KoreaAdvanced Photonics Research Institute, Gwangju Institute of Science and Technology, 123 Cheomdan Gwagiro, Bukgu, Gwangju 61005, Republic of KoreaDepartment of Biomedical Science and Engineering, Institute of Integrated Technology, Gwangju Institute of Science and Technology, 123 Cheomdan Gwagiro, Bukgu, Gwangju 61005, Republic of KoreaDepartment of Biomedical Science and Engineering, Institute of Integrated Technology, Gwangju Institute of Science and Technology, 123 Cheomdan Gwagiro, Bukgu, Gwangju 61005, Republic of KoreaAdvanced Photonics Research Institute, Gwangju Institute of Science and Technology, 123 Cheomdan Gwagiro, Bukgu, Gwangju 61005, Republic of KoreaDepartment of Biomedical Science and Engineering, Institute of Integrated Technology, Gwangju Institute of Science and Technology, 123 Cheomdan Gwagiro, Bukgu, Gwangju 61005, Republic of KoreaThe cancer field effect (CFE) has been highlighted as one of indirect indications for tissue variations that are insensitive to conventional diagnostic techniques. In this research, we had a hypothesis that chemotherapy for breast cancer would affect skin biochemical compositions that would be reflected by Raman spectral changes. We used a fiber-optic probe-based Raman spectroscopy to perform preliminary animal experiments to validate the hypothesis. Firstly, we verified the probing depth of the fiber-optic probe (~800 μm) using a simple intravenous fat emulsion-filled phantom having a silicon wafer at the bottom inside a cuvette. Then, we obtained Raman spectra during breast cancer treatment by chemotherapy from a small animal model in longitudinal manner. Our results showed that the treatment causes variations of biochemical compositions in the skin. For further validation, the Raman spectra will have to be collected from more populations and spectra will need to be compared with immunohistochemistry of the breast tissue.http://dx.doi.org/10.1155/2017/3595078 |
| spellingShingle | Myeongsu Seong NoSoung Myoung Songhyun Lee Hyeryun Jeong Sang-Youp Yim Jae Gwan Kim Longitudinal Raman Spectroscopic Observation of Skin Biochemical Changes due to Chemotherapeutic Treatment for Breast Cancer in Small Animal Model Journal of Spectroscopy |
| title | Longitudinal Raman Spectroscopic Observation of Skin Biochemical Changes due to Chemotherapeutic Treatment for Breast Cancer in Small Animal Model |
| title_full | Longitudinal Raman Spectroscopic Observation of Skin Biochemical Changes due to Chemotherapeutic Treatment for Breast Cancer in Small Animal Model |
| title_fullStr | Longitudinal Raman Spectroscopic Observation of Skin Biochemical Changes due to Chemotherapeutic Treatment for Breast Cancer in Small Animal Model |
| title_full_unstemmed | Longitudinal Raman Spectroscopic Observation of Skin Biochemical Changes due to Chemotherapeutic Treatment for Breast Cancer in Small Animal Model |
| title_short | Longitudinal Raman Spectroscopic Observation of Skin Biochemical Changes due to Chemotherapeutic Treatment for Breast Cancer in Small Animal Model |
| title_sort | longitudinal raman spectroscopic observation of skin biochemical changes due to chemotherapeutic treatment for breast cancer in small animal model |
| url | http://dx.doi.org/10.1155/2017/3595078 |
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