<sup>1</sup>H Nuclear Magnetic Resonance-Based Targeted and Untargeted Metabolomics Profiling of Retail Samples of Cuachalalate (<i>Amphipterygium adstringens</i>)

<sup>1</sup>H Nuclear Magnetic Resonance-Based Targeted and Untargeted Metabolomics Profiling of Retail Samples of Cuachalalate (<i>Amphipterygium adstringens</i>)

<i>Amphipterygium adstringens</i> (cuachalalate) is a medicinal plant widely used in traditional Mexican medicine for its anti-inflammatory, gastroprotective, and antimicrobial properties. In this study, we applied qualitative and quantitative NMR-based metabolomics profiling, combined w...

Full description

Saved in:
Bibliographic Details
Main Authors: Erick Alejandro Herrera-Jurado, Estefanía De Jesús Terán-Sánchez, José Iván Serrano-Contreras, L. Gerardo Zepeda-Vallejo
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Molecules
Subjects:
<i>Amphipterygium adstringens</i>
cuachalalate
<sup>1</sup>H NMR
metabolomics profiling
3α-hydroxy-masticadienoic acid
anacardic acids
Online Access:https://www.mdpi.com/1420-3049/30/10/2185
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:<i>Amphipterygium adstringens</i> (cuachalalate) is a medicinal plant widely used in traditional Mexican medicine for its anti-inflammatory, gastroprotective, and antimicrobial properties. In this study, we applied qualitative and quantitative NMR-based metabolomics profiling, combined with multivariate statistical analyses, including Principal Component Analysis (PCA), Partial Least Squares Discriminant Analysis (PLS-DA), and S-plots, to evaluate the chemical composition and authenticity of <i>A. adstringens</i> samples collected from different commercial sources sold in Mexico City. Metabolomic profiles in organic and aqueous extracts revealed highly similar spectral patterns among all collected samples, supporting the consistency of commercially available <i>A. adstringens</i> in Mexico. The presence of 3α-hydroxy-masticadienoic acid (3α-HMDA) and anacardic acids, biomarkers of the genus, was confirmed by <sup>1</sup>H NMR in hexane extracts; in the aqueous extract they were not observed with the same analytical platform. These findings suggest that the traditional infusion method may not effectively extract the above-mentioned key bioactive compounds. This approach enhances quality control and ensures the reliability of <i>A. adstringens</i> products in the commercial market.
ISSN:1420-3049

Similar Items