Restoration of NOX4 signalling reverses endothelial colony-forming cell angiogenic dysfunction associated with experimental and clinical diabetes

Restoration of NOX4 signalling reverses endothelial colony-forming cell angiogenic dysfunction associated with experimental and clinical diabetes

Abstract Background Progenitor endothelial colony forming cells (ECFCs) are critical for vascular homeostasis and hold therapeutic potential for ischaemic cardiovascular disease (CVD). As angiogenic capacity and efficacy within diseased tissues is particularly impacted in diabetic patients, who show...

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Main Authors: Karla M. O’Neill, Kevin S. Edgar, Shun Hay Pun, David C. Campbell, Tinrui Toh, Xin N. Wong, Bianca Botezatu, Jyoti Kandel, Una McCoy, Jennifer Nicell, Catherine McClintock, Kiran J. McLoughlin, Yuxin Wu, Vinuthna Vani Madishetti, Arya Moez, Mohammed Alsaggaf, Eleanor K. Gill, Rawan A. Abudalo, Christina L. O’Neill, Edoardo Pedrini, Jasenka Guduric-Fuchs, Coy Brunssen, Henning Morawietz, Philip D. Dunne, Chris J. Watson, Reinhold J. Medina, David J. Grieve
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Stem Cell Research & Therapy
Subjects:
NADPH oxidase 4
Endothelial progenitor cells
Angiogenesis
Diabetes cardiovascular diseases
Online Access:https://doi.org/10.1186/s13287-025-04393-4
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