Hydrogel local drug delivery systems for postsurgical management of tumors: Status Quo and perspectives
Surgery is one of the primary treatments for solid tumors. However, the incomplete resection of tumor cells and the immunosuppressive microenvironment make the issue of postsurgical tumor recurrence a great challenge. Furthermore, a wide range of requirements, including ensuring effective hemostasis...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006424003697 |
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| author | Ziqiao Zhong Lu Gan Ziyi Feng Wenhao Wang Xin Pan Chuanbin Wu Ying Huang |
| author_facet | Ziqiao Zhong Lu Gan Ziyi Feng Wenhao Wang Xin Pan Chuanbin Wu Ying Huang |
| author_sort | Ziqiao Zhong |
| collection | DOAJ |
| description | Surgery is one of the primary treatments for solid tumors. However, the incomplete resection of tumor cells and the immunosuppressive microenvironment make the issue of postsurgical tumor recurrence a great challenge. Furthermore, a wide range of requirements, including ensuring effective hemostasis, implementing prophylactic measures against infection, and promoting wound healing, were also raised in the postsurgical management of tumors. To fulfill these demands, multiple hydrogel local drug delivery systems (HLDDS) were developed recently. These HLDDS are expected to offer numerous advantages in the postsurgical management of tumors, such as achieving high local drug concentrations at the lesion, efficient delivery to surgical microcavities, mitigating systemic side effects, and addressing the diverse demand. Thus, in this review, a detailed discussion of the diverse demands of postsurgical management of tumors is provided. And the current publication trend on HLDDS in the postsurgical management of tumors is analyzed and discussed. Then, the applications of different types of HLDDS, in-situ HLDDS and non-in-situ HLDDS, in postsurgical management of tumors were introduced and summarized. Besides, the current problems and future perspectives are discussed. The review is expected to provide an overview of HLDDS in postsurgical management of tumors and promote their clinical application. |
| format | Article |
| id | doaj-art-4c3eac02c982474cbadc68a6779c4f6d |
| institution | OA Journals |
| issn | 2590-0064 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-4c3eac02c982474cbadc68a6779c4f6d2025-08-20T01:55:30ZengElsevierMaterials Today Bio2590-00642024-12-012910130810.1016/j.mtbio.2024.101308Hydrogel local drug delivery systems for postsurgical management of tumors: Status Quo and perspectivesZiqiao Zhong0Lu Gan1Ziyi Feng2Wenhao Wang3Xin Pan4Chuanbin Wu5Ying Huang6State Key Laboratory of Bioactive Molecules and Druggability Assessment, College of Pharmacy, Jinan University, Guangzhou, 511443, PR ChinaState Key Laboratory of Bioactive Molecules and Druggability Assessment, College of Pharmacy, Jinan University, Guangzhou, 511443, PR ChinaState Key Laboratory of Bioactive Molecules and Druggability Assessment, College of Pharmacy, Jinan University, Guangzhou, 511443, PR ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, PR China; Corresponding author.School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, PR ChinaState Key Laboratory of Bioactive Molecules and Druggability Assessment, College of Pharmacy, Jinan University, Guangzhou, 511443, PR ChinaState Key Laboratory of Bioactive Molecules and Druggability Assessment, College of Pharmacy, Jinan University, Guangzhou, 511443, PR China; Corresponding author.Surgery is one of the primary treatments for solid tumors. However, the incomplete resection of tumor cells and the immunosuppressive microenvironment make the issue of postsurgical tumor recurrence a great challenge. Furthermore, a wide range of requirements, including ensuring effective hemostasis, implementing prophylactic measures against infection, and promoting wound healing, were also raised in the postsurgical management of tumors. To fulfill these demands, multiple hydrogel local drug delivery systems (HLDDS) were developed recently. These HLDDS are expected to offer numerous advantages in the postsurgical management of tumors, such as achieving high local drug concentrations at the lesion, efficient delivery to surgical microcavities, mitigating systemic side effects, and addressing the diverse demand. Thus, in this review, a detailed discussion of the diverse demands of postsurgical management of tumors is provided. And the current publication trend on HLDDS in the postsurgical management of tumors is analyzed and discussed. Then, the applications of different types of HLDDS, in-situ HLDDS and non-in-situ HLDDS, in postsurgical management of tumors were introduced and summarized. Besides, the current problems and future perspectives are discussed. The review is expected to provide an overview of HLDDS in postsurgical management of tumors and promote their clinical application.http://www.sciencedirect.com/science/article/pii/S2590006424003697Hydrogel local drug delivery systemsTumors recurrencePostsurgical managementStimuli-responsive materials |
| spellingShingle | Ziqiao Zhong Lu Gan Ziyi Feng Wenhao Wang Xin Pan Chuanbin Wu Ying Huang Hydrogel local drug delivery systems for postsurgical management of tumors: Status Quo and perspectives Materials Today Bio Hydrogel local drug delivery systems Tumors recurrence Postsurgical management Stimuli-responsive materials |
| title | Hydrogel local drug delivery systems for postsurgical management of tumors: Status Quo and perspectives |
| title_full | Hydrogel local drug delivery systems for postsurgical management of tumors: Status Quo and perspectives |
| title_fullStr | Hydrogel local drug delivery systems for postsurgical management of tumors: Status Quo and perspectives |
| title_full_unstemmed | Hydrogel local drug delivery systems for postsurgical management of tumors: Status Quo and perspectives |
| title_short | Hydrogel local drug delivery systems for postsurgical management of tumors: Status Quo and perspectives |
| title_sort | hydrogel local drug delivery systems for postsurgical management of tumors status quo and perspectives |
| topic | Hydrogel local drug delivery systems Tumors recurrence Postsurgical management Stimuli-responsive materials |
| url | http://www.sciencedirect.com/science/article/pii/S2590006424003697 |
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