TLR2 Expression in Relation to IL-6 and IL-1β and their Natural Regulators Production by PMN and PBMC in Patients with Lyme Disease
Recently, it has been reported that TLR2 on macrophages plays a unique role in the inflammatory response and host defense to infection with Borrelia burgdorferi (Bb) which is an etiologic agent of Lyme disease. Experimental studies show that PMNs also play an essential role in infection control by B...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/32071 |
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| author | Ewa Jablonska Magdalena Marcinczyk |
| author_facet | Ewa Jablonska Magdalena Marcinczyk |
| author_sort | Ewa Jablonska |
| collection | DOAJ |
| description | Recently, it has been reported that TLR2 on macrophages plays a unique
role in the inflammatory response and host defense to infection
with Borrelia burgdorferi (Bb) which is an etiologic agent of
Lyme disease. Experimental studies show that PMNs also play an
essential role in infection control by Bb. However,
there is no available data about TLR2 expression on PMN in the
course of Lyme disease. In the present study, TLR2 expression and
production of IL-1β and IL-6 as well as their natural
regulators (sIL-1RII, IL-1Ra and sIL-6Rα, sgp130, resp) by
PMN of peripheral blood in patients with Lyme disease were
examined. For the purpose of comparison, the same activity of
autologous peripheral blood mononuclear cells (PBMCs) was estimated. An
effect of rhIL-15 on TLR2 and cytokine secretion was also studied.
Increased TLR2 expression in unstimulated neutrophils suggests an
important role of these cells in mechanism recognition of B
burgdorferi in patients with Lyme disease. The relationship
between IL-1β and IL-6 as well as their regulators by
unstimulated PMN and PBMC, observed in the present study, may lead
to enhanced IL-6- and to inhibition of IL-1β-mediated
reactions in this patient group. Changes in the TLR2 expression
after rhIL-15 stimulation appear to have a favorable effect on
mechanism recognition of Bb. The relations between IL-6
and its regulators (sIL-6Rα and sgp130) as well as between
IL-1β and its regulators (IL-1Ra and sIL-1RII) after rhIL-15
stimulation may lead to enhanced IL-1β- and IL-6-mediated
inflammatory reactions in the course of Lyme disease. |
| format | Article |
| id | doaj-art-4c3c4e4155944103a2f4360625019f03 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4c3c4e4155944103a2f4360625019f032025-02-03T05:59:56ZengWileyMediators of Inflammation0962-93511466-18612006-01-01200610.1155/MI/2006/3207132071TLR2 Expression in Relation to IL-6 and IL-1β and their Natural Regulators Production by PMN and PBMC in Patients with Lyme DiseaseEwa Jablonska0Magdalena Marcinczyk1Department of Immunology, Medical University of Bialystok, Wyszynskiego 15A, Bialystok 15274, PolandDepartment of Immunology, Medical University of Bialystok, Wyszynskiego 15A, Bialystok 15274, PolandRecently, it has been reported that TLR2 on macrophages plays a unique role in the inflammatory response and host defense to infection with Borrelia burgdorferi (Bb) which is an etiologic agent of Lyme disease. Experimental studies show that PMNs also play an essential role in infection control by Bb. However, there is no available data about TLR2 expression on PMN in the course of Lyme disease. In the present study, TLR2 expression and production of IL-1β and IL-6 as well as their natural regulators (sIL-1RII, IL-1Ra and sIL-6Rα, sgp130, resp) by PMN of peripheral blood in patients with Lyme disease were examined. For the purpose of comparison, the same activity of autologous peripheral blood mononuclear cells (PBMCs) was estimated. An effect of rhIL-15 on TLR2 and cytokine secretion was also studied. Increased TLR2 expression in unstimulated neutrophils suggests an important role of these cells in mechanism recognition of B burgdorferi in patients with Lyme disease. The relationship between IL-1β and IL-6 as well as their regulators by unstimulated PMN and PBMC, observed in the present study, may lead to enhanced IL-6- and to inhibition of IL-1β-mediated reactions in this patient group. Changes in the TLR2 expression after rhIL-15 stimulation appear to have a favorable effect on mechanism recognition of Bb. The relations between IL-6 and its regulators (sIL-6Rα and sgp130) as well as between IL-1β and its regulators (IL-1Ra and sIL-1RII) after rhIL-15 stimulation may lead to enhanced IL-1β- and IL-6-mediated inflammatory reactions in the course of Lyme disease.http://dx.doi.org/10.1155/MI/2006/32071 |
| spellingShingle | Ewa Jablonska Magdalena Marcinczyk TLR2 Expression in Relation to IL-6 and IL-1β and their Natural Regulators Production by PMN and PBMC in Patients with Lyme Disease Mediators of Inflammation |
| title | TLR2 Expression in Relation to IL-6 and IL-1β and their
Natural Regulators Production by PMN and PBMC in Patients with
Lyme Disease |
| title_full | TLR2 Expression in Relation to IL-6 and IL-1β and their
Natural Regulators Production by PMN and PBMC in Patients with
Lyme Disease |
| title_fullStr | TLR2 Expression in Relation to IL-6 and IL-1β and their
Natural Regulators Production by PMN and PBMC in Patients with
Lyme Disease |
| title_full_unstemmed | TLR2 Expression in Relation to IL-6 and IL-1β and their
Natural Regulators Production by PMN and PBMC in Patients with
Lyme Disease |
| title_short | TLR2 Expression in Relation to IL-6 and IL-1β and their
Natural Regulators Production by PMN and PBMC in Patients with
Lyme Disease |
| title_sort | tlr2 expression in relation to il 6 and il 1β and their natural regulators production by pmn and pbmc in patients with lyme disease |
| url | http://dx.doi.org/10.1155/MI/2006/32071 |
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