TLR2 Expression in Relation to IL-6 and IL-1β and their Natural Regulators Production by PMN and PBMC in Patients with Lyme Disease
Recently, it has been reported that TLR2 on macrophages plays a unique role in the inflammatory response and host defense to infection with Borrelia burgdorferi (Bb) which is an etiologic agent of Lyme disease. Experimental studies show that PMNs also play an essential role in infection control by B...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/32071 |
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| Summary: | Recently, it has been reported that TLR2 on macrophages plays a unique
role in the inflammatory response and host defense to infection
with Borrelia burgdorferi (Bb) which is an etiologic agent of
Lyme disease. Experimental studies show that PMNs also play an
essential role in infection control by Bb. However,
there is no available data about TLR2 expression on PMN in the
course of Lyme disease. In the present study, TLR2 expression and
production of IL-1β and IL-6 as well as their natural
regulators (sIL-1RII, IL-1Ra and sIL-6Rα, sgp130, resp) by
PMN of peripheral blood in patients with Lyme disease were
examined. For the purpose of comparison, the same activity of
autologous peripheral blood mononuclear cells (PBMCs) was estimated. An
effect of rhIL-15 on TLR2 and cytokine secretion was also studied.
Increased TLR2 expression in unstimulated neutrophils suggests an
important role of these cells in mechanism recognition of B
burgdorferi in patients with Lyme disease. The relationship
between IL-1β and IL-6 as well as their regulators by
unstimulated PMN and PBMC, observed in the present study, may lead
to enhanced IL-6- and to inhibition of IL-1β-mediated
reactions in this patient group. Changes in the TLR2 expression
after rhIL-15 stimulation appear to have a favorable effect on
mechanism recognition of Bb. The relations between IL-6
and its regulators (sIL-6Rα and sgp130) as well as between
IL-1β and its regulators (IL-1Ra and sIL-1RII) after rhIL-15
stimulation may lead to enhanced IL-1β- and IL-6-mediated
inflammatory reactions in the course of Lyme disease. |
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| ISSN: | 0962-9351 1466-1861 |