Dietary Se-enrich Cardamine violifolia supplementation decreases lipid deposition and improves antioxidant status in the liver of aging laying hens
Aging-related lipid metabolic disorder is related to oxidative stress. Selenium (Se)-enriched Cardamine violifolia (SEC) is known for its excellent antioxidant function. The objective of this study was to evaluate the effects of SEC on antioxidant capacity and lipid metabolism in the liver of aged l...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Poultry Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0032579124011982 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832591835912994816 |
|---|---|
| author | Mengke Yan Xin Cong Hui Wang Kun Qin Yuhui Tang Xiao Xu Dan Wang Shuiyuan Cheng Yulan Liu Huiling Zhu |
| author_facet | Mengke Yan Xin Cong Hui Wang Kun Qin Yuhui Tang Xiao Xu Dan Wang Shuiyuan Cheng Yulan Liu Huiling Zhu |
| author_sort | Mengke Yan |
| collection | DOAJ |
| description | Aging-related lipid metabolic disorder is related to oxidative stress. Selenium (Se)-enriched Cardamine violifolia (SEC) is known for its excellent antioxidant function. The objective of this study was to evaluate the effects of SEC on antioxidant capacity and lipid metabolism in the liver of aged laying hens. A total of 450 sixty-five-wk-old Roman laying hens were randomly divided into 5 treatments: a basal diet (without Se supplementation, CON) and basal diets supplemented with 0.3 mg/kg Se from sodium selenite (SS), 0.3 mg/kg Se from Se-enriched yeast (SEY), 0.3 mg/kg Se from SEC (SEC), or 0.3 mg/kg Se from SEC and 0.3 mg/kg Se from SEY (SEC + SEY). The experiment lasted for 8 wk. The results showed that dietary SEC + SEY supplementation decreased (P < 0.05) triglyceride (in the plasma and liver) and total cholesterol levels (in the plasma), and increased (P < 0.05) HDL-C concentration in plasma compared to CON diet. Compared with CON diet, SEC and/or SEY supplementation decreased (P < 0.05) the mRNA expression of hepatic ACC, FAS and HMGCR, and increased (P < 0.05) PPARα, VTG-II, Apo-VLDL II and ApoB expression. Dietary SEC + SEY and SEY supplementation increased (P < 0.05) Se content in egg yolk and breast muscle compared to CON diet. Dietary SEC, SEY or SEC + SEY supplementation increased (P < 0.05) the activity of antioxidant enzymes (GSH-PX, T-AOC and T-SOD) in the plasma and liver and decreased (P < 0.05) MDA content in the plasma compared to CON diet. Dietary Se supplementation promoted (P < 0.05) mRNA expression of Nrf2 in the liver. In contrast, dietary SEY and SEC supplementation resulted in a decrease (P < 0.05) of hepatic Keap1 mRNA expression compared to CON diet. Dietary SEC + SEY and/or SEC supplementation increased (P < 0.05) mRNA expression of Selenof, GPX1 and GPX4 in the liver compared with CON diet. In conclusion, dietary SEC (0.3 mg/kg Se) or SEC (0.3 mg/kg Se) + SEY (0.3 mg/kg Se) improved the antioxidant capacity and the lipid metabolism in the liver of aged laying hens, which might be associated with regulating Nrf2/Keap1 signaling pathway. |
| format | Article |
| id | doaj-art-4c3b92fd9281430f867846bf4f742c97 |
| institution | Kabale University |
| issn | 0032-5791 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Poultry Science |
| spelling | doaj-art-4c3b92fd9281430f867846bf4f742c972025-01-22T05:40:45ZengElsevierPoultry Science0032-57912025-01-011041104620Dietary Se-enrich Cardamine violifolia supplementation decreases lipid deposition and improves antioxidant status in the liver of aging laying hensMengke Yan0Xin Cong1Hui Wang2Kun Qin3Yuhui Tang4Xiao Xu5Dan Wang6Shuiyuan Cheng7Yulan Liu8Huiling Zhu9Hubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, No. 68 Xuefu South Road, Changqing Garden, Wuhan 430048, ChinaNational R&D Center for Se-Rich Agricultural Products Processing, School of Modern Industry for Selenium Science and Engineering, Wuhan Polytechnic University, Wuhan 430048, China; Enshi Se-Run Material Engineering Technology Co., Ltd., Enshi 445000, ChinaHubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, No. 68 Xuefu South Road, Changqing Garden, Wuhan 430048, ChinaHubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, No. 68 Xuefu South Road, Changqing Garden, Wuhan 430048, ChinaHubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, No. 68 Xuefu South Road, Changqing Garden, Wuhan 430048, ChinaHubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, No. 68 Xuefu South Road, Changqing Garden, Wuhan 430048, ChinaHubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, No. 68 Xuefu South Road, Changqing Garden, Wuhan 430048, ChinaNational R&D Center for Se-Rich Agricultural Products Processing, School of Modern Industry for Selenium Science and Engineering, Wuhan Polytechnic University, Wuhan 430048, ChinaHubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, No. 68 Xuefu South Road, Changqing Garden, Wuhan 430048, ChinaHubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, No. 68 Xuefu South Road, Changqing Garden, Wuhan 430048, China; Corresponding author.Aging-related lipid metabolic disorder is related to oxidative stress. Selenium (Se)-enriched Cardamine violifolia (SEC) is known for its excellent antioxidant function. The objective of this study was to evaluate the effects of SEC on antioxidant capacity and lipid metabolism in the liver of aged laying hens. A total of 450 sixty-five-wk-old Roman laying hens were randomly divided into 5 treatments: a basal diet (without Se supplementation, CON) and basal diets supplemented with 0.3 mg/kg Se from sodium selenite (SS), 0.3 mg/kg Se from Se-enriched yeast (SEY), 0.3 mg/kg Se from SEC (SEC), or 0.3 mg/kg Se from SEC and 0.3 mg/kg Se from SEY (SEC + SEY). The experiment lasted for 8 wk. The results showed that dietary SEC + SEY supplementation decreased (P < 0.05) triglyceride (in the plasma and liver) and total cholesterol levels (in the plasma), and increased (P < 0.05) HDL-C concentration in plasma compared to CON diet. Compared with CON diet, SEC and/or SEY supplementation decreased (P < 0.05) the mRNA expression of hepatic ACC, FAS and HMGCR, and increased (P < 0.05) PPARα, VTG-II, Apo-VLDL II and ApoB expression. Dietary SEC + SEY and SEY supplementation increased (P < 0.05) Se content in egg yolk and breast muscle compared to CON diet. Dietary SEC, SEY or SEC + SEY supplementation increased (P < 0.05) the activity of antioxidant enzymes (GSH-PX, T-AOC and T-SOD) in the plasma and liver and decreased (P < 0.05) MDA content in the plasma compared to CON diet. Dietary Se supplementation promoted (P < 0.05) mRNA expression of Nrf2 in the liver. In contrast, dietary SEY and SEC supplementation resulted in a decrease (P < 0.05) of hepatic Keap1 mRNA expression compared to CON diet. Dietary SEC + SEY and/or SEC supplementation increased (P < 0.05) mRNA expression of Selenof, GPX1 and GPX4 in the liver compared with CON diet. In conclusion, dietary SEC (0.3 mg/kg Se) or SEC (0.3 mg/kg Se) + SEY (0.3 mg/kg Se) improved the antioxidant capacity and the lipid metabolism in the liver of aged laying hens, which might be associated with regulating Nrf2/Keap1 signaling pathway.http://www.sciencedirect.com/science/article/pii/S0032579124011982Selenium-enriched Cardamine violifoliaAged laying henLiverAntioxidant capacityLipid metabolism |
| spellingShingle | Mengke Yan Xin Cong Hui Wang Kun Qin Yuhui Tang Xiao Xu Dan Wang Shuiyuan Cheng Yulan Liu Huiling Zhu Dietary Se-enrich Cardamine violifolia supplementation decreases lipid deposition and improves antioxidant status in the liver of aging laying hens Poultry Science Selenium-enriched Cardamine violifolia Aged laying hen Liver Antioxidant capacity Lipid metabolism |
| title | Dietary Se-enrich Cardamine violifolia supplementation decreases lipid deposition and improves antioxidant status in the liver of aging laying hens |
| title_full | Dietary Se-enrich Cardamine violifolia supplementation decreases lipid deposition and improves antioxidant status in the liver of aging laying hens |
| title_fullStr | Dietary Se-enrich Cardamine violifolia supplementation decreases lipid deposition and improves antioxidant status in the liver of aging laying hens |
| title_full_unstemmed | Dietary Se-enrich Cardamine violifolia supplementation decreases lipid deposition and improves antioxidant status in the liver of aging laying hens |
| title_short | Dietary Se-enrich Cardamine violifolia supplementation decreases lipid deposition and improves antioxidant status in the liver of aging laying hens |
| title_sort | dietary se enrich cardamine violifolia supplementation decreases lipid deposition and improves antioxidant status in the liver of aging laying hens |
| topic | Selenium-enriched Cardamine violifolia Aged laying hen Liver Antioxidant capacity Lipid metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S0032579124011982 |
| work_keys_str_mv | AT mengkeyan dietaryseenrichcardamineviolifoliasupplementationdecreaseslipiddepositionandimprovesantioxidantstatusintheliverofaginglayinghens AT xincong dietaryseenrichcardamineviolifoliasupplementationdecreaseslipiddepositionandimprovesantioxidantstatusintheliverofaginglayinghens AT huiwang dietaryseenrichcardamineviolifoliasupplementationdecreaseslipiddepositionandimprovesantioxidantstatusintheliverofaginglayinghens AT kunqin dietaryseenrichcardamineviolifoliasupplementationdecreaseslipiddepositionandimprovesantioxidantstatusintheliverofaginglayinghens AT yuhuitang dietaryseenrichcardamineviolifoliasupplementationdecreaseslipiddepositionandimprovesantioxidantstatusintheliverofaginglayinghens AT xiaoxu dietaryseenrichcardamineviolifoliasupplementationdecreaseslipiddepositionandimprovesantioxidantstatusintheliverofaginglayinghens AT danwang dietaryseenrichcardamineviolifoliasupplementationdecreaseslipiddepositionandimprovesantioxidantstatusintheliverofaginglayinghens AT shuiyuancheng dietaryseenrichcardamineviolifoliasupplementationdecreaseslipiddepositionandimprovesantioxidantstatusintheliverofaginglayinghens AT yulanliu dietaryseenrichcardamineviolifoliasupplementationdecreaseslipiddepositionandimprovesantioxidantstatusintheliverofaginglayinghens AT huilingzhu dietaryseenrichcardamineviolifoliasupplementationdecreaseslipiddepositionandimprovesantioxidantstatusintheliverofaginglayinghens |