Investigating the regulation of the miR-199a-3p/TGF-β/Smad signaling pathway by BSHXF drug-containing serum combined with ADSCs for delaying intervertebral disc degeneration

Investigating the regulation of the miR-199a-3p/TGF-β/Smad signaling pathway by BSHXF drug-containing serum combined with ADSCs for delaying intervertebral disc degeneration

BackgroundIntervertebral disc degeneration (IDD) significantly contributes to low back pain (LBP), yet effective treatment options are scarce. BSHXF, a classical traditional Chinese medicine formula, demonstrates dual pharmacological actions: tonifying kidneys, strengthening bones, activating blood...

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Main Authors: Enxu Liu, Yu Sun, Lei Yang, Haobo Jiang, Fei Sun, Long Chen, Jiahao Duan, Shaofeng Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
intervertebral disc degeneration
miR-199a-3p/TGF-β/Smad signaling pathway
adipose-derived stem cells
oxidative stress
extracellular matrix synthesis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1583635/full
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