The microbiota-gut-brain axis and central nervous system diseases: from mechanisms of pathogenesis to therapeutic strategies
The gut microbiota plays a crucial role in metabolic processes associated with host brain function. Emerging research is progressively uncovering the intricate and multifaceted relationship between the gut and the brain. The gut microbiota significantly influences immune responses, secondary metabol...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-06-01
|
| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1583562/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849468957766975488 |
|---|---|
| author | Jie Xu Yi Lu |
| author_facet | Jie Xu Yi Lu |
| author_sort | Jie Xu |
| collection | DOAJ |
| description | The gut microbiota plays a crucial role in metabolic processes associated with host brain function. Emerging research is progressively uncovering the intricate and multifaceted relationship between the gut and the brain. The gut microbiota significantly influences immune responses, secondary metabolism, and symbiosis with the host, thereby facilitating the production of essential metabolites, neurotransmitters, and other neuroactive compounds that impact the development and treatment of central nervous system disorders. This article delineates the communication pathways and mechanisms linking the microbiota, gut, and brain, providing a comprehensive overview of current research on how the gut microbiota affects nervous system function. Furthermore, it examines factors that can alter the gut microbiota and influence metabolite profiles, as well as current intervention strategies aimed at enhancing gut-brain communication, mitigating adverse triggers that disrupt the gut microbiota, and minimizing neuro-pathological changes. |
| format | Article |
| id | doaj-art-4c354de233bc4f2ba87dcc19dfcd628a |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-4c354de233bc4f2ba87dcc19dfcd628a2025-08-20T03:25:40ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-06-011610.3389/fmicb.2025.15835621583562The microbiota-gut-brain axis and central nervous system diseases: from mechanisms of pathogenesis to therapeutic strategiesJie XuYi LuThe gut microbiota plays a crucial role in metabolic processes associated with host brain function. Emerging research is progressively uncovering the intricate and multifaceted relationship between the gut and the brain. The gut microbiota significantly influences immune responses, secondary metabolism, and symbiosis with the host, thereby facilitating the production of essential metabolites, neurotransmitters, and other neuroactive compounds that impact the development and treatment of central nervous system disorders. This article delineates the communication pathways and mechanisms linking the microbiota, gut, and brain, providing a comprehensive overview of current research on how the gut microbiota affects nervous system function. Furthermore, it examines factors that can alter the gut microbiota and influence metabolite profiles, as well as current intervention strategies aimed at enhancing gut-brain communication, mitigating adverse triggers that disrupt the gut microbiota, and minimizing neuro-pathological changes.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1583562/fullmicrobiota-gut-brain axiscentral nervous system diseasesgut microbiotapathogenesistreatment |
| spellingShingle | Jie Xu Yi Lu The microbiota-gut-brain axis and central nervous system diseases: from mechanisms of pathogenesis to therapeutic strategies Frontiers in Microbiology microbiota-gut-brain axis central nervous system diseases gut microbiota pathogenesis treatment |
| title | The microbiota-gut-brain axis and central nervous system diseases: from mechanisms of pathogenesis to therapeutic strategies |
| title_full | The microbiota-gut-brain axis and central nervous system diseases: from mechanisms of pathogenesis to therapeutic strategies |
| title_fullStr | The microbiota-gut-brain axis and central nervous system diseases: from mechanisms of pathogenesis to therapeutic strategies |
| title_full_unstemmed | The microbiota-gut-brain axis and central nervous system diseases: from mechanisms of pathogenesis to therapeutic strategies |
| title_short | The microbiota-gut-brain axis and central nervous system diseases: from mechanisms of pathogenesis to therapeutic strategies |
| title_sort | microbiota gut brain axis and central nervous system diseases from mechanisms of pathogenesis to therapeutic strategies |
| topic | microbiota-gut-brain axis central nervous system diseases gut microbiota pathogenesis treatment |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1583562/full |
| work_keys_str_mv | AT jiexu themicrobiotagutbrainaxisandcentralnervoussystemdiseasesfrommechanismsofpathogenesistotherapeuticstrategies AT yilu themicrobiotagutbrainaxisandcentralnervoussystemdiseasesfrommechanismsofpathogenesistotherapeuticstrategies AT jiexu microbiotagutbrainaxisandcentralnervoussystemdiseasesfrommechanismsofpathogenesistotherapeuticstrategies AT yilu microbiotagutbrainaxisandcentralnervoussystemdiseasesfrommechanismsofpathogenesistotherapeuticstrategies |