Ethanol extract of propolis-bovine bone graft combination as a prospective candidate for socket preservation: Enhancing BMP7 and decreasing NFATc1
Objective: To analyse the expression of BMP7 in osteoblasts and NFATc1 in osteoclasts during the bone healing process in the extraction socket and the possible relationship between the expression of BMP7 and NFATc1. Methodology: This study represented a post-test only control group design consisting...
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| Language: | English |
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Springer
2021-12-01
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| Series: | Saudi Dental Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1013905221000559 |
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| author | Utari Kresnoadi Jennifer Widjaja Harry Laksono |
| author_facet | Utari Kresnoadi Jennifer Widjaja Harry Laksono |
| author_sort | Utari Kresnoadi |
| collection | DOAJ |
| description | Objective: To analyse the expression of BMP7 in osteoblasts and NFATc1 in osteoclasts during the bone healing process in the extraction socket and the possible relationship between the expression of BMP7 and NFATc1. Methodology: This study represented a post-test only control group design consisting of four groups, namely; a control group (polyethylene glycol), an ethanol extract of propolis (EEP) group, a bovine bone graft (BBG) group, and a EEP-BBG group. 56 Cavia cobaya were split randomly into four groups. The mandibula left incisors of the subjects were extracted, treated with certain materials according to their group, and sutured. The expression of BMP7 and NFATc1 was observed on day 7 and day 14 by means of immunohistochemical staining. Statistical analysis was performed using a combination of one-way ANOVA, Games-Howell post-hoc, and Pearson tests. Results: The propolis-BBG combination group showed the highest BMP7 expression, on both day 7 and day 14. With regard to NFATc1 expression, the combination group experienced the lowest expression on day 7 and day 14. The combination group showed significant differences in all expressions compared to the control group. The BMP7 and NFATc1 expressions showed a strong relationship (r = -0.598, r > 0.5) Conclusion: Propolis-BBG combination increases BMP7 expression and reduces NFATc1 expression in the extraction socket. This study confirmed a strong relationship between the expressions of BMP7 and NFATc1. |
| format | Article |
| id | doaj-art-4c341d9c57cb4d2bbaa819fca33cec0b |
| institution | DOAJ |
| issn | 1013-9052 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | Springer |
| record_format | Article |
| series | Saudi Dental Journal |
| spelling | doaj-art-4c341d9c57cb4d2bbaa819fca33cec0b2025-08-20T03:20:13ZengSpringerSaudi Dental Journal1013-90522021-12-013381055106210.1016/j.sdentj.2021.05.003Ethanol extract of propolis-bovine bone graft combination as a prospective candidate for socket preservation: Enhancing BMP7 and decreasing NFATc1Utari Kresnoadi0Jennifer Widjaja1Harry Laksono2Department of Prosthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia; Corresponding author at: Department of Prosthodontics, Faculty of Dental Medicine, Universitas Airlangga, Jl. Mayjend Prof. Dr. Moestopo 47, Surabaya 60132, Indonesia.Resident of Prosthodontic Department, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, IndonesiaDepartment of Prosthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, IndonesiaObjective: To analyse the expression of BMP7 in osteoblasts and NFATc1 in osteoclasts during the bone healing process in the extraction socket and the possible relationship between the expression of BMP7 and NFATc1. Methodology: This study represented a post-test only control group design consisting of four groups, namely; a control group (polyethylene glycol), an ethanol extract of propolis (EEP) group, a bovine bone graft (BBG) group, and a EEP-BBG group. 56 Cavia cobaya were split randomly into four groups. The mandibula left incisors of the subjects were extracted, treated with certain materials according to their group, and sutured. The expression of BMP7 and NFATc1 was observed on day 7 and day 14 by means of immunohistochemical staining. Statistical analysis was performed using a combination of one-way ANOVA, Games-Howell post-hoc, and Pearson tests. Results: The propolis-BBG combination group showed the highest BMP7 expression, on both day 7 and day 14. With regard to NFATc1 expression, the combination group experienced the lowest expression on day 7 and day 14. The combination group showed significant differences in all expressions compared to the control group. The BMP7 and NFATc1 expressions showed a strong relationship (r = -0.598, r > 0.5) Conclusion: Propolis-BBG combination increases BMP7 expression and reduces NFATc1 expression in the extraction socket. This study confirmed a strong relationship between the expressions of BMP7 and NFATc1.http://www.sciencedirect.com/science/article/pii/S1013905221000559PropolisBovine bone graftBMP7NFATc1Socket preservation |
| spellingShingle | Utari Kresnoadi Jennifer Widjaja Harry Laksono Ethanol extract of propolis-bovine bone graft combination as a prospective candidate for socket preservation: Enhancing BMP7 and decreasing NFATc1 Saudi Dental Journal Propolis Bovine bone graft BMP7 NFATc1 Socket preservation |
| title | Ethanol extract of propolis-bovine bone graft combination as a prospective candidate for socket preservation: Enhancing BMP7 and decreasing NFATc1 |
| title_full | Ethanol extract of propolis-bovine bone graft combination as a prospective candidate for socket preservation: Enhancing BMP7 and decreasing NFATc1 |
| title_fullStr | Ethanol extract of propolis-bovine bone graft combination as a prospective candidate for socket preservation: Enhancing BMP7 and decreasing NFATc1 |
| title_full_unstemmed | Ethanol extract of propolis-bovine bone graft combination as a prospective candidate for socket preservation: Enhancing BMP7 and decreasing NFATc1 |
| title_short | Ethanol extract of propolis-bovine bone graft combination as a prospective candidate for socket preservation: Enhancing BMP7 and decreasing NFATc1 |
| title_sort | ethanol extract of propolis bovine bone graft combination as a prospective candidate for socket preservation enhancing bmp7 and decreasing nfatc1 |
| topic | Propolis Bovine bone graft BMP7 NFATc1 Socket preservation |
| url | http://www.sciencedirect.com/science/article/pii/S1013905221000559 |
| work_keys_str_mv | AT utarikresnoadi ethanolextractofpropolisbovinebonegraftcombinationasaprospectivecandidateforsocketpreservationenhancingbmp7anddecreasingnfatc1 AT jenniferwidjaja ethanolextractofpropolisbovinebonegraftcombinationasaprospectivecandidateforsocketpreservationenhancingbmp7anddecreasingnfatc1 AT harrylaksono ethanolextractofpropolisbovinebonegraftcombinationasaprospectivecandidateforsocketpreservationenhancingbmp7anddecreasingnfatc1 |