Time-window of offline long-term potentiation in anterior cingulate cortex during memory consolidation and recall
Episodic memories are initially formed in the hippocampus and subsequently transferred to cortical regions for long-term storage. This process, known as memory consolidation, involves plastic changes in synaptic transmission such as long-term potentiation (LTP). However, at what time points and spec...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-03-01
|
| Series: | Neuroscience Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0168010224001639 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849709459529531392 |
|---|---|
| author | Junyu Liu Akihiro Goto Yasunori Hayashi |
| author_facet | Junyu Liu Akihiro Goto Yasunori Hayashi |
| author_sort | Junyu Liu |
| collection | DOAJ |
| description | Episodic memories are initially formed in the hippocampus and subsequently transferred to cortical regions for long-term storage. This process, known as memory consolidation, involves plastic changes in synaptic transmission such as long-term potentiation (LTP). However, at what time points and specific locations LTP acts at remains unclear. We previously developed an optogenetic tool, cofilin-SuperNova (CFL-SN), that allows for the selective erasure of LTP within a limited time window. Using CFL-SN, here we show that the erasure of LTP in the anterior cingulate cortex (ACC) during sleep on the subsequent day, but not immediately following task acquisition, impairs recall of memory. However, allowing a single day without perturbation allowed memory to be recalled. Even after 7 days of repeated erasure of LTP, allowing LTP in the ACC on the 8th day restores memory recall. Once the memory is transferred, further LTP in the ACC is not necessary. Our findings indicates that the memory consolidation process completes in one sleep cycle and can occur at any timepoint up to 8th day. |
| format | Article |
| id | doaj-art-4c2c9d6520d04e6db4c92ada351d672f |
| institution | DOAJ |
| issn | 0168-0102 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neuroscience Research |
| spelling | doaj-art-4c2c9d6520d04e6db4c92ada351d672f2025-08-20T03:15:17ZengElsevierNeuroscience Research0168-01022025-03-01212758310.1016/j.neures.2024.12.009Time-window of offline long-term potentiation in anterior cingulate cortex during memory consolidation and recallJunyu Liu0Akihiro Goto1Yasunori Hayashi2Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, JapanDepartment of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan; Hakubi Center for Advanced Research, Kyoto University, Kyoto 606-8501, Japan; PRESTO, Japan Science and Technology Agency (JST), Tokyo, JapanDepartment of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan; Corresponding author.Episodic memories are initially formed in the hippocampus and subsequently transferred to cortical regions for long-term storage. This process, known as memory consolidation, involves plastic changes in synaptic transmission such as long-term potentiation (LTP). However, at what time points and specific locations LTP acts at remains unclear. We previously developed an optogenetic tool, cofilin-SuperNova (CFL-SN), that allows for the selective erasure of LTP within a limited time window. Using CFL-SN, here we show that the erasure of LTP in the anterior cingulate cortex (ACC) during sleep on the subsequent day, but not immediately following task acquisition, impairs recall of memory. However, allowing a single day without perturbation allowed memory to be recalled. Even after 7 days of repeated erasure of LTP, allowing LTP in the ACC on the 8th day restores memory recall. Once the memory is transferred, further LTP in the ACC is not necessary. Our findings indicates that the memory consolidation process completes in one sleep cycle and can occur at any timepoint up to 8th day.http://www.sciencedirect.com/science/article/pii/S0168010224001639memory consolidationsynaptic plasticitylong-term potentiationanterior cingulate cortexcofilin |
| spellingShingle | Junyu Liu Akihiro Goto Yasunori Hayashi Time-window of offline long-term potentiation in anterior cingulate cortex during memory consolidation and recall Neuroscience Research memory consolidation synaptic plasticity long-term potentiation anterior cingulate cortex cofilin |
| title | Time-window of offline long-term potentiation in anterior cingulate cortex during memory consolidation and recall |
| title_full | Time-window of offline long-term potentiation in anterior cingulate cortex during memory consolidation and recall |
| title_fullStr | Time-window of offline long-term potentiation in anterior cingulate cortex during memory consolidation and recall |
| title_full_unstemmed | Time-window of offline long-term potentiation in anterior cingulate cortex during memory consolidation and recall |
| title_short | Time-window of offline long-term potentiation in anterior cingulate cortex during memory consolidation and recall |
| title_sort | time window of offline long term potentiation in anterior cingulate cortex during memory consolidation and recall |
| topic | memory consolidation synaptic plasticity long-term potentiation anterior cingulate cortex cofilin |
| url | http://www.sciencedirect.com/science/article/pii/S0168010224001639 |
| work_keys_str_mv | AT junyuliu timewindowofofflinelongtermpotentiationinanteriorcingulatecortexduringmemoryconsolidationandrecall AT akihirogoto timewindowofofflinelongtermpotentiationinanteriorcingulatecortexduringmemoryconsolidationandrecall AT yasunorihayashi timewindowofofflinelongtermpotentiationinanteriorcingulatecortexduringmemoryconsolidationandrecall |