Efferent Treatment for Critical Conditions

Endogenous intoxication as a typical pathological process has been and remains one of the key problems in virtually all fields of medicine and mainly in reanimatology. Accumulation of endogenous toxic substances is an integral component of any critical condition and accompanies severe injury, genera...

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Main Authors: S. E. Khoroshilov, A. V. Nikulin
Format: Article
Language:English
Published: Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia 2012-08-01
Series:Общая реаниматология
Online Access:https://www.reanimatology.com/rmt/article/view/208
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author S. E. Khoroshilov
A. V. Nikulin
author_facet S. E. Khoroshilov
A. V. Nikulin
author_sort S. E. Khoroshilov
collection DOAJ
description Endogenous intoxication as a typical pathological process has been and remains one of the key problems in virtually all fields of medicine and mainly in reanimatology. Accumulation of endogenous toxic substances is an integral component of any critical condition and accompanies severe injury, generalized infections, abdominal organ derangement. Loss of the function of detoxifying systems in multiple organ dysfunction leads to progressive endotoxicosis and worsening gas exchange disorders, including detoxification in the organs themselves, thus closing the vicious circle of tanatogenesis. Endogenous intoxication is a multidisciplinary problem that is the area of many different fields of practical medicine, experimental pathophysiology, and biomedical technology. Thus, current efferent therapeutic techniques for critical conditions and extracorporeal detoxification in particular are being introduced into clinical practice. The V. A. Negovsky Research Institute of General Reanimatology, Russian Academy of Medical Sciences, has been studying the theoretical and applied issues concerning the problem of endotoxicosis for many years. This review attempts to generalize the main results the Institute’s activity in this area. Key words: endogenous intoxication, efferent therapy, detoxification.
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spelling doaj-art-4c2c4c2894b3498bbf70ab30ac662ef92025-08-20T02:55:49ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102012-08-018410.15360/1813-9779-2012-4-30208Efferent Treatment for Critical ConditionsS. E. KhoroshilovA. V. NikulinEndogenous intoxication as a typical pathological process has been and remains one of the key problems in virtually all fields of medicine and mainly in reanimatology. Accumulation of endogenous toxic substances is an integral component of any critical condition and accompanies severe injury, generalized infections, abdominal organ derangement. Loss of the function of detoxifying systems in multiple organ dysfunction leads to progressive endotoxicosis and worsening gas exchange disorders, including detoxification in the organs themselves, thus closing the vicious circle of tanatogenesis. Endogenous intoxication is a multidisciplinary problem that is the area of many different fields of practical medicine, experimental pathophysiology, and biomedical technology. Thus, current efferent therapeutic techniques for critical conditions and extracorporeal detoxification in particular are being introduced into clinical practice. The V. A. Negovsky Research Institute of General Reanimatology, Russian Academy of Medical Sciences, has been studying the theoretical and applied issues concerning the problem of endotoxicosis for many years. This review attempts to generalize the main results the Institute’s activity in this area. Key words: endogenous intoxication, efferent therapy, detoxification.https://www.reanimatology.com/rmt/article/view/208
spellingShingle S. E. Khoroshilov
A. V. Nikulin
Efferent Treatment for Critical Conditions
Общая реаниматология
title Efferent Treatment for Critical Conditions
title_full Efferent Treatment for Critical Conditions
title_fullStr Efferent Treatment for Critical Conditions
title_full_unstemmed Efferent Treatment for Critical Conditions
title_short Efferent Treatment for Critical Conditions
title_sort efferent treatment for critical conditions
url https://www.reanimatology.com/rmt/article/view/208
work_keys_str_mv AT sekhoroshilov efferenttreatmentforcriticalconditions
AT avnikulin efferenttreatmentforcriticalconditions