Non-canonical activation of MAPK signaling by the lncRNA ASH1L-AS1-encoded microprotein APPLE through inhibition of PP1/PP2A-mediated ERK1/2 dephosphorylation in hepatocellular carcinoma

Non-canonical activation of MAPK signaling by the lncRNA ASH1L-AS1-encoded microprotein APPLE through inhibition of PP1/PP2A-mediated ERK1/2 dephosphorylation in hepatocellular carcinoma

Abstract Background MAPK/ERK1/2 signaling is often activated in hepatocellular carcinoma (HCC), yet classical RAS-RAF-MEK mutations are rare, indicating the involvement of non-canonical regulatory mechanisms. Long non-coding RNAs (lncRNAs) can encode microproteins that play key roles in cancer. LncR...

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Bibliographic Details
Main Authors: Lei Zhao, Ke Si, Shenjian Luo, Lantian Zhang, Shuai Mao, Wenliang Zhang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
ASH1L-AS1
Liver cancer
LncRNA encoded-microprotein
MAPK signaling
PP1/PP2A
Online Access:https://doi.org/10.1186/s13046-025-03465-w
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https://doi.org/10.1186/s13046-025-03465-w

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