Nicotinic cholinergic regulation of olfactory bulb blood flow response in aged rats
Abstract In our previous research, we had demonstrated the crucial role of neuronal nicotinic acetylcholine receptors (nAChRs) in potentiation of the olfactory bulb blood flow response to olfactory stimulation in adult rats. The present study examined the effects of nAChR activation on the olfactory...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-03-01
|
| Series: | Journal of Physiological Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12576-022-00859-9 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849694077256204288 |
|---|---|
| author | Sae Uchida Jura Moriya Daichi Morihara Fusako Kagitani |
| author_facet | Sae Uchida Jura Moriya Daichi Morihara Fusako Kagitani |
| author_sort | Sae Uchida |
| collection | DOAJ |
| description | Abstract In our previous research, we had demonstrated the crucial role of neuronal nicotinic acetylcholine receptors (nAChRs) in potentiation of the olfactory bulb blood flow response to olfactory stimulation in adult rats. The present study examined the effects of nAChR activation on the olfactory bulb blood flow response in rats aged 24–27 months. We found that, under urethane anesthesia, unilateral olfactory nerve stimulation (300 μA, 20 Hz, 5 s) increased blood flow within the ipsilateral olfactory bulb, without changes in the systemic arterial pressure. The increase in blood flow was dependent upon the current and frequency of the stimulus. Intravenous administration of nicotine (30 μg/kg) had little effect on the olfactory bulb blood flow response to nerve stimulation at either 2 Hz or 20 Hz. These results suggest a reduction in nAChR-mediated potentiation of the olfactory bulb blood flow response in aged rats. |
| format | Article |
| id | doaj-art-4c25aa61bf234d2b9c285cc104cd0949 |
| institution | DOAJ |
| issn | 1880-6562 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Physiological Sciences |
| spelling | doaj-art-4c25aa61bf234d2b9c285cc104cd09492025-08-20T03:20:13ZengElsevierJournal of Physiological Sciences1880-65622023-03-017311810.1186/s12576-022-00859-9Nicotinic cholinergic regulation of olfactory bulb blood flow response in aged ratsSae Uchida0Jura Moriya1Daichi Morihara2Fusako Kagitani3Department of Autonomic Neuroscience, Tokyo Metropolitan Institute of GerontologyDepartment of Autonomic Neuroscience, Tokyo Metropolitan Institute of GerontologyDepartment of Autonomic Neuroscience, Tokyo Metropolitan Institute of GerontologyDepartment of Autonomic Neuroscience, Tokyo Metropolitan Institute of GerontologyAbstract In our previous research, we had demonstrated the crucial role of neuronal nicotinic acetylcholine receptors (nAChRs) in potentiation of the olfactory bulb blood flow response to olfactory stimulation in adult rats. The present study examined the effects of nAChR activation on the olfactory bulb blood flow response in rats aged 24–27 months. We found that, under urethane anesthesia, unilateral olfactory nerve stimulation (300 μA, 20 Hz, 5 s) increased blood flow within the ipsilateral olfactory bulb, without changes in the systemic arterial pressure. The increase in blood flow was dependent upon the current and frequency of the stimulus. Intravenous administration of nicotine (30 μg/kg) had little effect on the olfactory bulb blood flow response to nerve stimulation at either 2 Hz or 20 Hz. These results suggest a reduction in nAChR-mediated potentiation of the olfactory bulb blood flow response in aged rats.https://doi.org/10.1186/s12576-022-00859-9AgingOlfactory bulbCerebral blood flowOlfactory nerve stimulationNicotinic acetylcholine receptorsRats |
| spellingShingle | Sae Uchida Jura Moriya Daichi Morihara Fusako Kagitani Nicotinic cholinergic regulation of olfactory bulb blood flow response in aged rats Journal of Physiological Sciences Aging Olfactory bulb Cerebral blood flow Olfactory nerve stimulation Nicotinic acetylcholine receptors Rats |
| title | Nicotinic cholinergic regulation of olfactory bulb blood flow response in aged rats |
| title_full | Nicotinic cholinergic regulation of olfactory bulb blood flow response in aged rats |
| title_fullStr | Nicotinic cholinergic regulation of olfactory bulb blood flow response in aged rats |
| title_full_unstemmed | Nicotinic cholinergic regulation of olfactory bulb blood flow response in aged rats |
| title_short | Nicotinic cholinergic regulation of olfactory bulb blood flow response in aged rats |
| title_sort | nicotinic cholinergic regulation of olfactory bulb blood flow response in aged rats |
| topic | Aging Olfactory bulb Cerebral blood flow Olfactory nerve stimulation Nicotinic acetylcholine receptors Rats |
| url | https://doi.org/10.1186/s12576-022-00859-9 |
| work_keys_str_mv | AT saeuchida nicotiniccholinergicregulationofolfactorybulbbloodflowresponseinagedrats AT juramoriya nicotiniccholinergicregulationofolfactorybulbbloodflowresponseinagedrats AT daichimorihara nicotiniccholinergicregulationofolfactorybulbbloodflowresponseinagedrats AT fusakokagitani nicotiniccholinergicregulationofolfactorybulbbloodflowresponseinagedrats |