Vitamin D Deficiency in Obese Children and Its Relationship to Insulin Resistance and Adipokines
Low-serum concentrations of 25-hydroxyvitamin D [25(OH)D] are associated with insulin resistance in adults. Less data are available in pediatric populations. Serum 25(OH)D serum concentrations were assessed in 125 obese and 31 nonobese children (age 11.9±2.7 y, range 6–16 y, 49% male) living in Bonn...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2011/495101 |
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| author | Christian L. Roth Clinton Elfers Mario Kratz Andrew N. Hoofnagle |
| author_facet | Christian L. Roth Clinton Elfers Mario Kratz Andrew N. Hoofnagle |
| author_sort | Christian L. Roth |
| collection | DOAJ |
| description | Low-serum concentrations of 25-hydroxyvitamin D [25(OH)D] are associated with insulin resistance in adults. Less data are available in pediatric populations. Serum 25(OH)D serum concentrations were assessed in 125 obese and 31 nonobese children (age 11.9±2.7 y, range 6–16 y, 49% male) living in Bonn, Germany. The relationship between 25(OH)D, measured by liquid chromatography-tandem mass spectrometry, and measures of insulin sensitivity and adipokines adiponectin and resistin were analyzed. Seventy-six % of subjects were 25(OH)D deficient (<20 ng/mL). Higher insulin, homeostasis model assessment-insulin resistance (HOMA-IR r=−0.269, P=0.023), and hemoglobin A1c (HbA1c) as well as lower quantitative insulin-sensitivity check index (QUICKI r=0.264, P=0.030) values were found in obese children with lower 25(OH)D concentrations even after adjustment for gender, age, and body mass index. Furthermore, 25(OH)D correlated significantly with adiponectin, but not with resistin. Our results suggest that hypovitaminosis D is a risk factor for developing insulin resistance independent of adiposity. |
| format | Article |
| id | doaj-art-4c1f5562216c4415a67d75ffeea73251 |
| institution | OA Journals |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-4c1f5562216c4415a67d75ffeea732512025-08-20T02:38:39ZengWileyJournal of Obesity2090-07082090-07162011-01-01201110.1155/2011/495101495101Vitamin D Deficiency in Obese Children and Its Relationship to Insulin Resistance and AdipokinesChristian L. Roth0Clinton Elfers1Mario Kratz2Andrew N. Hoofnagle3Division of Endocrinology, Seattle Children's Research Institute, 1900 Ninth Avenue, Seattle, WA 98101, USADivision of Endocrinology, Seattle Children's Research Institute, 1900 Ninth Avenue, Seattle, WA 98101, USAFred Hutchinson Cancer Research Center, Seattle, WA 98109, USADepartment of Medicine, University of Washington, Seattle, WA 98195, USALow-serum concentrations of 25-hydroxyvitamin D [25(OH)D] are associated with insulin resistance in adults. Less data are available in pediatric populations. Serum 25(OH)D serum concentrations were assessed in 125 obese and 31 nonobese children (age 11.9±2.7 y, range 6–16 y, 49% male) living in Bonn, Germany. The relationship between 25(OH)D, measured by liquid chromatography-tandem mass spectrometry, and measures of insulin sensitivity and adipokines adiponectin and resistin were analyzed. Seventy-six % of subjects were 25(OH)D deficient (<20 ng/mL). Higher insulin, homeostasis model assessment-insulin resistance (HOMA-IR r=−0.269, P=0.023), and hemoglobin A1c (HbA1c) as well as lower quantitative insulin-sensitivity check index (QUICKI r=0.264, P=0.030) values were found in obese children with lower 25(OH)D concentrations even after adjustment for gender, age, and body mass index. Furthermore, 25(OH)D correlated significantly with adiponectin, but not with resistin. Our results suggest that hypovitaminosis D is a risk factor for developing insulin resistance independent of adiposity.http://dx.doi.org/10.1155/2011/495101 |
| spellingShingle | Christian L. Roth Clinton Elfers Mario Kratz Andrew N. Hoofnagle Vitamin D Deficiency in Obese Children and Its Relationship to Insulin Resistance and Adipokines Journal of Obesity |
| title | Vitamin D Deficiency in Obese Children and Its Relationship to Insulin Resistance and Adipokines |
| title_full | Vitamin D Deficiency in Obese Children and Its Relationship to Insulin Resistance and Adipokines |
| title_fullStr | Vitamin D Deficiency in Obese Children and Its Relationship to Insulin Resistance and Adipokines |
| title_full_unstemmed | Vitamin D Deficiency in Obese Children and Its Relationship to Insulin Resistance and Adipokines |
| title_short | Vitamin D Deficiency in Obese Children and Its Relationship to Insulin Resistance and Adipokines |
| title_sort | vitamin d deficiency in obese children and its relationship to insulin resistance and adipokines |
| url | http://dx.doi.org/10.1155/2011/495101 |
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