Dynamics of polymorphism in a malaria vaccine antigen at a vaccine-testing site in Mali.

Dynamics of polymorphism in a malaria vaccine antigen at a vaccine-testing site in Mali.

<h4>Background</h4>Malaria vaccines based on the 19-kDa region of merozoite surface protein 1 (MSP-1(19)) derived from the 3D7 strain of Plasmodium falciparum are being tested in clinical trials in Africa. Knowledge of the distribution and natural dynamics of vaccine antigen polymorphism...

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Main Authors: Shannon L Takala, Drissa Coulibaly, Mahamadou A Thera, Alassane Dicko, David L Smith, Ando B Guindo, Abdoulaye K Kone, Karim Traore, Amed Ouattara, Abdoulaye A Djimde, Paul S Sehdev, Kirsten E Lyke, Dapa A Diallo, Ogobara K Doumbo, Christopher V Plowe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-03-01
Series:PLoS Medicine
Online Access:https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.0040093&type=printable
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