Protein losses caused by peritoneal dialysis and influencing factors
Objective To investigate the components of protein in peritoneal dialysate and explore the risk factors causing the protein losses in the peritoneal dialysis patients in Donghua hospital. Methods122 uremic patients( 79 males and 43 females) undergoing continuous ambulatory peritoneal dialysis( CAPD)...
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Editorial Department of Journal of Clinical Nephrology
2017-01-01
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| Series: | Linchuang shenzangbing zazhi |
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| author | TANG Xing-ming HU Jie-ping DENG Hui-zhao LIN Jian ZHENG Wei-ping ZOU Zhao-hui |
| author_facet | TANG Xing-ming HU Jie-ping DENG Hui-zhao LIN Jian ZHENG Wei-ping ZOU Zhao-hui |
| author_sort | TANG Xing-ming |
| collection | DOAJ |
| description | Objective To investigate the components of protein in peritoneal dialysate and explore the risk factors causing the protein losses in the peritoneal dialysis patients in Donghua hospital. Methods122 uremic patients( 79 males and 43 females) undergoing continuous ambulatory peritoneal dialysis( CAPD)were enrolled and assigned into high protein losses group( HP) and low protein losses group( LP) according the median losses of protein in dialysate from March 1,2015 to Feb. 28,2016. The amount and component of the protein in dialysate were accessed by the immunoturbidimetry and electrophoresis,and the demographic data and clinical data were collected to analyze the difference between the two groups. The logistic regression was applied to disclose the risk factors of the protein losses via dialysate. Results The median of protein losses in CAPD dialysis patients was 4. 18 g/24 h,the major component was albumin( 0. 36 g/L),the other components were transferrin,IgG and Ig A,and all of them were more eliminated in the dialysate of patients in HP group( P < 0. 001). Furthermore,the patients in HP group showed lower serum albumin( 37. 33 ± 3. 85 vs.39. 05 ± 3. 88 g/L,P < 0. 001) and higher rate with high transport status( 59. 0% vs. 34. 4%,P =0. 006),and high peritoneal transport was risk factors of high protein losses by dialysate( OR 3. 08,95%CI 1. 41-6. 75). Conclusions CAPD patients may lose substantial amount of protein by dialysis solution,the major components was albumin,and high peritoneal transport was risk factors of high protein losses by dialysate. |
| format | Article |
| id | doaj-art-4c0440c84cd14ae5bfaffa9709cf82b2 |
| institution | Kabale University |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2017-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-4c0440c84cd14ae5bfaffa9709cf82b22025-08-20T03:49:02ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902017-01-0159459757916320Protein losses caused by peritoneal dialysis and influencing factorsTANG Xing-mingHU Jie-pingDENG Hui-zhaoLIN JianZHENG Wei-pingZOU Zhao-huiObjective To investigate the components of protein in peritoneal dialysate and explore the risk factors causing the protein losses in the peritoneal dialysis patients in Donghua hospital. Methods122 uremic patients( 79 males and 43 females) undergoing continuous ambulatory peritoneal dialysis( CAPD)were enrolled and assigned into high protein losses group( HP) and low protein losses group( LP) according the median losses of protein in dialysate from March 1,2015 to Feb. 28,2016. The amount and component of the protein in dialysate were accessed by the immunoturbidimetry and electrophoresis,and the demographic data and clinical data were collected to analyze the difference between the two groups. The logistic regression was applied to disclose the risk factors of the protein losses via dialysate. Results The median of protein losses in CAPD dialysis patients was 4. 18 g/24 h,the major component was albumin( 0. 36 g/L),the other components were transferrin,IgG and Ig A,and all of them were more eliminated in the dialysate of patients in HP group( P < 0. 001). Furthermore,the patients in HP group showed lower serum albumin( 37. 33 ± 3. 85 vs.39. 05 ± 3. 88 g/L,P < 0. 001) and higher rate with high transport status( 59. 0% vs. 34. 4%,P =0. 006),and high peritoneal transport was risk factors of high protein losses by dialysate( OR 3. 08,95%CI 1. 41-6. 75). Conclusions CAPD patients may lose substantial amount of protein by dialysis solution,the major components was albumin,and high peritoneal transport was risk factors of high protein losses by dialysate.http://www.lcszb.com/thesisDetails?columnId=57916320&Fpath=home&index=0UremiaPeritoneal dialysisProtein losses by dialysate |
| spellingShingle | TANG Xing-ming HU Jie-ping DENG Hui-zhao LIN Jian ZHENG Wei-ping ZOU Zhao-hui Protein losses caused by peritoneal dialysis and influencing factors Linchuang shenzangbing zazhi Uremia Peritoneal dialysis Protein losses by dialysate |
| title | Protein losses caused by peritoneal dialysis and influencing factors |
| title_full | Protein losses caused by peritoneal dialysis and influencing factors |
| title_fullStr | Protein losses caused by peritoneal dialysis and influencing factors |
| title_full_unstemmed | Protein losses caused by peritoneal dialysis and influencing factors |
| title_short | Protein losses caused by peritoneal dialysis and influencing factors |
| title_sort | protein losses caused by peritoneal dialysis and influencing factors |
| topic | Uremia Peritoneal dialysis Protein losses by dialysate |
| url | http://www.lcszb.com/thesisDetails?columnId=57916320&Fpath=home&index=0 |
| work_keys_str_mv | AT tangxingming proteinlossescausedbyperitonealdialysisandinfluencingfactors AT hujieping proteinlossescausedbyperitonealdialysisandinfluencingfactors AT denghuizhao proteinlossescausedbyperitonealdialysisandinfluencingfactors AT linjian proteinlossescausedbyperitonealdialysisandinfluencingfactors AT zhengweiping proteinlossescausedbyperitonealdialysisandinfluencingfactors AT zouzhaohui proteinlossescausedbyperitonealdialysisandinfluencingfactors |