Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity.

Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity.

Epidermal keratinocytes form a highly organized stratified epithelium and sustain a competent barrier function together with dermal and hematopoietic cells. The Notch signaling pathway is a critical regulator of epidermal integrity. Here, we show that keratinocyte-specific deletion of total Notch si...

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Bibliographic Details
Main Authors: Shadmehr Demehri, Zhenyi Liu, Jonghyeob Lee, Meei-Hua Lin, Seth D Crosby, Christopher J Roberts, Perry W Grigsby, Jeffrey H Miner, Andrew G Farr, Raphael Kopan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-05-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.0060123&type=printable
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