Solvent-Free Ring Cleavage Hydrazinolysis of Certain Biginelli Pyrimidines

Solvent-Free Ring Cleavage Hydrazinolysis of Certain Biginelli Pyrimidines

Certain Biginelli pyrimidines with ester substitution in C5 were subjected to unexpected ring opening upon solvent-free reaction with hydrazine hydrate to give three products: pyrazole, arylidenehydrazines, and urea/thiourea, respectively. The nonisolable carbohydrazide intermediates are formed firs...

Full description

Saved in:

Bibliographic Details
Main Authors:	Mohamed A. Said, Wagdy M. Eldehna, Hazem A. Ghabbour, Maha M. Kabil, Nasser S. Al-shakliah, Hatem A. Abdel-Aziz
Format:	Article
Language:	English
Published:	Wiley 2018-01-01
Series:	Journal of Chemistry
Online Access:	http://dx.doi.org/10.1155/2018/6354742
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Hydrolysis and Hydrazinolysis of Isatin-Based Ald- and Ketazines
by: Hany S. Ibrahim, et al.
Published: (2015-01-01)

Microwave-Assisted Synthesis and Characterization of Certain Oximes, Hydrazones, and Olefins Derived from β-Keto Sulfones
by: Hatem A. Abdel-Aziz, et al.
Published: (2014-01-01)

On structure of certain periodic rings and near-rings
by: Moharram A. Khan
Published: (2000-01-01)

Oxidative Cleavage of β-Keto Sulfones via Nitrous Acid
by: Hatem A. Abdel-Aziz
Published: (2014-01-01)

Certain near-rings are rings, II
by: Howard E. Bell
Published: (1986-01-01)

A Facile Synthesis of Pyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidine and Pyrido[2′,3′:3,4]pyrazolo[5,1-c][1,2,4]triazine Bearing a Thiophene Moiety
by: Tilal Elsaman, et al.
Published: (2013-01-01)

Degradation of black tea theaflavin through C-ring cleavage by gut microbiota
by: Shuwei Zhang, et al.
Published: (2022-05-01)

On certain classes of Galois extensions of rings
by: George Szeto, et al.
Published: (2001-01-01)

Structure of rings with certain conditions on zero divisors
by: Hazar Abu-Khuzam, et al.
Published: (2006-01-01)

A note on rings with certain variables identities
by: Hazar Abu-Khuzam
Published: (1989-01-01)

Indium-catalysed ring opening of 2-hydroxybutyrolactone through the cleavage of C(sp$^3$)–O bond
by: Aoun, Sameh, et al.
Published: (2023-09-01)

Lithium-Acetate-Mediated Biginelli One-Pot Multicomponent Synthesis under Solvent-Free Conditions and Cytotoxic Activity against the Human Lung Cancer Cell Line A549 and Breast Cancer Cell Line MCF7
by: Harshita Sachdeva, et al.
Published: (2012-01-01)

Anticonvulsant Potential of Certain New (2E)-2-[1-Aryl-3-(1H-imidazol-1-yl)propylidene]-N-(aryl/H)hydrazinecarboxamides
by: Mohamed I. Attia, et al.
Published: (2014-01-01)

Pharmacological activities of some triazinopyrazolothieno pyrimidine derivatives
by: Bahashwan Saleh A.
Published: (2017-09-01)

Synthesis and X-Ray Crystal Structure of (1E)-1-(4-Chlorophenyl)-N-hydroxy-3-(1H-imidazol-1-yl)propan-1-imine
by: Mohamed I. Attia, et al.
Published: (2013-01-01)

Studies on Synthesis of Pyrimidine Derivatives and their Pharmacological Evaluation
by: T. A. Naik, et al.
Published: (2007-01-01)

Purification of Gst Fusion Proteins, On-Column Cleavage, and Sample Clean Up
by: Jill A. Sigrell, et al.
Published: (2002-01-01)

Synthesis and X-Ray Structure of (1Z,2Z)-1,2-Bis(2-(phenylsulfonyl)-1-(4-tolyl)ethylidene)hydrazine
by: Hatem A. Abdel-Aziz, et al.
Published: (2014-01-01)

Synthesis and Antibacterial Activity of Chalcones and Pyrimidine-2-ones
by: A. K. Parekh, et al.
Published: (2005-01-01)

Controllable intein splicing and N-terminal cleavage at mesophilic temperatures
by: Taylor A. McNeal, et al.
Published: (2025-02-01)

Peptide Backbone Cleavage and Transamidation via Thioester-to-Imide Acyl Transfer
by: Bengt H. Gless, et al.
Published: (2025-01-01)

Synthesis of Some Pyrimidine, Pyrazole, and Pyridine Derivatives and Their Reactivity Descriptors
by: Nour E. A. Abd El-Sattar, et al.
Published: (2018-01-01)

Trifluoroacetic Acid as an Effective Catalyst for Biginelli Reaction: One-Pot, Three-Component Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones (and-Thiones)
by: Mohammad R. Mohammadizadeh, et al.
Published: (2011-01-01)

Multi-stage structure-based virtual screening approach combining 3D pharmacophore, docking and molecular dynamic simulation towards the identification of potential selective PARP-1 inhibitors
by: Mahmoud A. El Hassab, et al.
Published: (2025-02-01)

PAK-2 Targeting to Mitochondria and Cleavage by Caspases Induces Apoptosis
by: Thomas Rudel, et al.
Published: (2001-01-01)

Lysophosphatidic Acid Signaling in Late Cleavage and Blastocyst Stage Bovine Embryos
by: Ana Catarina Torres, et al.
Published: (2014-01-01)

Evaluation of the genotoxic and transformation potential induced by asbestos compared to cleavage fragments
by: Sebastiano La Maestra, et al.
Published: (2025-01-01)

The Effect of the Film Thickness, Cooling Rate, and Solvent Evaporation on the Formation of <i>L</i>-Menthol Ring-Banded Spherulites
by: Tamás Kovács, et al.
Published: (2024-12-01)

Simple approach to thieno[3,2-d]pyrimidines as new scaffolds of antimicrobial activities
by: Hafez Hend N., et al.
Published: (2016-09-01)

Alkene Cleavage Catalysed by Heme and Nonheme Enzymes: Reaction Mechanisms and Biocatalytic Applications
by: Francesco G. Mutti
Published: (2012-01-01)

Studies on Synthesis of Some New Chalcone and Pyrimidines and their Antibacterial Activity
by: Ketan Mistry, et al.
Published: (2005-01-01)

Synthesis and Antimicrobial Activity of Pyrimidine Salts with Chloranilic and Picric Acids
by: C. Mallikarjunaswamy, et al.
Published: (2013-01-01)

On Classical Quotient Rings of Skew Armendariz Rings
by: A. R. Nasr-Isfahani, et al.
Published: (2007-01-01)

Studies on Synthesis of Some Novel Heterocyclic Chalcone, Pyrazoline, Pyrimidine - 2 - One, Pyrimidine - 2 - Thione, para-Acetanilide Sulphonyl and Benzoyl Derivatives and their Antimicrobial Activity
by: Rakesh N. Mistry, et al.
Published: (2005-01-01)

Corrigendum to “New Nanosized V(III), Fe(III), and Ni(II) Complexes Comprising Schiff Base and 2-Amino-4-Methyl Pyrimidine: Synthesis, Properties, and Biological Activity”
by: Maged S. Al-Fakeh, et al.
Published: (2024-01-01)

Mouse-derived Synaptosomes Trypsin Cleavage Assay to Characterize Synaptic Protein Sub-localization
by: Jasmeet Shergill, et al.
Published: (2025-01-01)

DNA Binding and Cleavage Activity of Binuclear Metal Complexes with Benzil-α-Monoxime Thiosemicarbzone
by: M. S. Surendra Babu, et al.
Published: (2011-01-01)

Elucidating the role of pyrimidine metabolism in prostate cancer and its therapeutic implications
by: Liang Huang, et al.
Published: (2025-01-01)

Novel thiazolyl-pyrimidine derivatives as potential anticancer agents: Synthesis, biological evaluation, and molecular docking studies
by: Tariq Z. Abolibda, et al.
Published: (2025-01-01)

Some External Characterizations of SV-Rings and Hereditary Rings
by: A. Haily, et al.
Published: (2007-01-01)