Prognostic Utility of the Modified Systemic Inflammation Score for Patients Undergoing Oral Cavity Cancer Surgery
Background/Objectives: Chronic inflammation significantly contributes to human malignancies. We investigated the prognostic significance of the preoperative modified systemic inflammation score (mSIS) in patients with primary oral cavity squamous cell carcinoma (OCSCC). Methods: We retrospectively r...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/14/24/2856 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850049835357437952 |
|---|---|
| author | Ku-Hao Fang Sheng-Wei Lo Adarsh Kudva Andrea De Vito Yuan-Hsiung Tsai Cheng-Ming Hsu Geng-He Chang Ethan I. Huang Ming-Shao Tsai Chia-Hsuan Lai Ming-Hsien Tsai Chun-Ta Liao Chung-Jan Kang Yao-Te Tsai |
| author_facet | Ku-Hao Fang Sheng-Wei Lo Adarsh Kudva Andrea De Vito Yuan-Hsiung Tsai Cheng-Ming Hsu Geng-He Chang Ethan I. Huang Ming-Shao Tsai Chia-Hsuan Lai Ming-Hsien Tsai Chun-Ta Liao Chung-Jan Kang Yao-Te Tsai |
| author_sort | Ku-Hao Fang |
| collection | DOAJ |
| description | Background/Objectives: Chronic inflammation significantly contributes to human malignancies. We investigated the prognostic significance of the preoperative modified systemic inflammation score (mSIS) in patients with primary oral cavity squamous cell carcinoma (OCSCC). Methods: We retrospectively reviewed data from 320 OCSCC patients who underwent curative surgery between 2007 and 2017. Based on preoperative lymphocyte-to-monocyte ratio (LMR) and serum albumin levels, patients were classified into three groups: mSIS = 2 (LMR < 3.4 and albumin < 4.0 g/dL), mSIS = 1 (LMR < 3.4 or albumin < 4.0 g/dL), and mSIS = 0 (LMR ≥ 3.4 and albumin ≥ 4.0 g/dL). We explored the associations between the preoperative mSIS and overall survival (OS) and disease-free survival (DFS). We developed a nomogram based on mSIS for OS prediction. Results: The distribution was mSIS = 0 (<i>n</i> = 197, 61.6%), mSIS = 1 (<i>n</i> = 99, 30.9%), and mSIS = 2 (<i>n</i> = 24, 7.5%). Kaplan–Meier estimated OS and DFS for the mSIS = 0, mSIS = 1, and mSIS = 2 groups demonstrated a sequential decrease (both <i>p</i> < 0.001). The prognostic significance of mSIS was consistent across subgroup analyses. Multivariable analysis revealed that mSIS = 1 and mSIS = 2 were independent negative prognostic indicators. The mSIS-based nomogram effectively predicted OS (concordance index: 0.755). Conclusions: The mSIS reliably predicts OS and DFS in OCSCC patients undergoing surgery, with the nomogram providing individualized OS estimates, enhancing mSIS’s clinical utility. |
| format | Article |
| id | doaj-art-4bfe1919c4e44c949ef49a8d70f1f61e |
| institution | DOAJ |
| issn | 2075-4418 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-4bfe1919c4e44c949ef49a8d70f1f61e2025-08-20T02:53:38ZengMDPI AGDiagnostics2075-44182024-12-011424285610.3390/diagnostics14242856Prognostic Utility of the Modified Systemic Inflammation Score for Patients Undergoing Oral Cavity Cancer SurgeryKu-Hao Fang0Sheng-Wei Lo1Adarsh Kudva2Andrea De Vito3Yuan-Hsiung Tsai4Cheng-Ming Hsu5Geng-He Chang6Ethan I. Huang7Ming-Shao Tsai8Chia-Hsuan Lai9Ming-Hsien Tsai10Chun-Ta Liao11Chung-Jan Kang12Yao-Te Tsai13Department of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Taoyuan 333423, TaiwanDepartment of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Chiayi 613016, TaiwanDepartment of Oral and Maxillofacial Surgery, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal 576104, IndiaEar Nose Throat (ENT) Unit, Department of Surgery, Forlì Hospital Health Local Agency of Romagna, 47121 Forlì, ItalyCollege of Medicine, Chang Gung University, Taoyuan 330036, TaiwanCollege of Medicine, Chang Gung University, Taoyuan 330036, TaiwanCollege of Medicine, Chang Gung University, Taoyuan 330036, TaiwanCollege of Medicine, Chang Gung University, Taoyuan 330036, TaiwanCollege of Medicine, Chang Gung University, Taoyuan 330036, TaiwanCollege of Medicine, Chang Gung University, Taoyuan 330036, TaiwanCollege of Medicine, Chang Gung University, Taoyuan 330036, TaiwanDepartment of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Taoyuan 333423, TaiwanDepartment of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Taoyuan 333423, TaiwanCollege of Medicine, Chang Gung University, Taoyuan 330036, TaiwanBackground/Objectives: Chronic inflammation significantly contributes to human malignancies. We investigated the prognostic significance of the preoperative modified systemic inflammation score (mSIS) in patients with primary oral cavity squamous cell carcinoma (OCSCC). Methods: We retrospectively reviewed data from 320 OCSCC patients who underwent curative surgery between 2007 and 2017. Based on preoperative lymphocyte-to-monocyte ratio (LMR) and serum albumin levels, patients were classified into three groups: mSIS = 2 (LMR < 3.4 and albumin < 4.0 g/dL), mSIS = 1 (LMR < 3.4 or albumin < 4.0 g/dL), and mSIS = 0 (LMR ≥ 3.4 and albumin ≥ 4.0 g/dL). We explored the associations between the preoperative mSIS and overall survival (OS) and disease-free survival (DFS). We developed a nomogram based on mSIS for OS prediction. Results: The distribution was mSIS = 0 (<i>n</i> = 197, 61.6%), mSIS = 1 (<i>n</i> = 99, 30.9%), and mSIS = 2 (<i>n</i> = 24, 7.5%). Kaplan–Meier estimated OS and DFS for the mSIS = 0, mSIS = 1, and mSIS = 2 groups demonstrated a sequential decrease (both <i>p</i> < 0.001). The prognostic significance of mSIS was consistent across subgroup analyses. Multivariable analysis revealed that mSIS = 1 and mSIS = 2 were independent negative prognostic indicators. The mSIS-based nomogram effectively predicted OS (concordance index: 0.755). Conclusions: The mSIS reliably predicts OS and DFS in OCSCC patients undergoing surgery, with the nomogram providing individualized OS estimates, enhancing mSIS’s clinical utility.https://www.mdpi.com/2075-4418/14/24/2856oral cavity cancersquamous cell carcinomamodified systemic inflammation scorenomogramsurvival outcomes |
| spellingShingle | Ku-Hao Fang Sheng-Wei Lo Adarsh Kudva Andrea De Vito Yuan-Hsiung Tsai Cheng-Ming Hsu Geng-He Chang Ethan I. Huang Ming-Shao Tsai Chia-Hsuan Lai Ming-Hsien Tsai Chun-Ta Liao Chung-Jan Kang Yao-Te Tsai Prognostic Utility of the Modified Systemic Inflammation Score for Patients Undergoing Oral Cavity Cancer Surgery Diagnostics oral cavity cancer squamous cell carcinoma modified systemic inflammation score nomogram survival outcomes |
| title | Prognostic Utility of the Modified Systemic Inflammation Score for Patients Undergoing Oral Cavity Cancer Surgery |
| title_full | Prognostic Utility of the Modified Systemic Inflammation Score for Patients Undergoing Oral Cavity Cancer Surgery |
| title_fullStr | Prognostic Utility of the Modified Systemic Inflammation Score for Patients Undergoing Oral Cavity Cancer Surgery |
| title_full_unstemmed | Prognostic Utility of the Modified Systemic Inflammation Score for Patients Undergoing Oral Cavity Cancer Surgery |
| title_short | Prognostic Utility of the Modified Systemic Inflammation Score for Patients Undergoing Oral Cavity Cancer Surgery |
| title_sort | prognostic utility of the modified systemic inflammation score for patients undergoing oral cavity cancer surgery |
| topic | oral cavity cancer squamous cell carcinoma modified systemic inflammation score nomogram survival outcomes |
| url | https://www.mdpi.com/2075-4418/14/24/2856 |
| work_keys_str_mv | AT kuhaofang prognosticutilityofthemodifiedsystemicinflammationscoreforpatientsundergoingoralcavitycancersurgery AT shengweilo prognosticutilityofthemodifiedsystemicinflammationscoreforpatientsundergoingoralcavitycancersurgery AT adarshkudva prognosticutilityofthemodifiedsystemicinflammationscoreforpatientsundergoingoralcavitycancersurgery AT andreadevito prognosticutilityofthemodifiedsystemicinflammationscoreforpatientsundergoingoralcavitycancersurgery AT yuanhsiungtsai prognosticutilityofthemodifiedsystemicinflammationscoreforpatientsundergoingoralcavitycancersurgery AT chengminghsu prognosticutilityofthemodifiedsystemicinflammationscoreforpatientsundergoingoralcavitycancersurgery AT genghechang prognosticutilityofthemodifiedsystemicinflammationscoreforpatientsundergoingoralcavitycancersurgery AT ethanihuang prognosticutilityofthemodifiedsystemicinflammationscoreforpatientsundergoingoralcavitycancersurgery AT mingshaotsai prognosticutilityofthemodifiedsystemicinflammationscoreforpatientsundergoingoralcavitycancersurgery AT chiahsuanlai prognosticutilityofthemodifiedsystemicinflammationscoreforpatientsundergoingoralcavitycancersurgery AT minghsientsai prognosticutilityofthemodifiedsystemicinflammationscoreforpatientsundergoingoralcavitycancersurgery AT chuntaliao prognosticutilityofthemodifiedsystemicinflammationscoreforpatientsundergoingoralcavitycancersurgery AT chungjankang prognosticutilityofthemodifiedsystemicinflammationscoreforpatientsundergoingoralcavitycancersurgery AT yaotetsai prognosticutilityofthemodifiedsystemicinflammationscoreforpatientsundergoingoralcavitycancersurgery |