Tumor volume changes after stereotactic, hypofractionated and conventional radiotherapy in paragangliomas of head and neck
Abstract Background The aim of this study is comparison the effectiveness of stereotactic, hypofractionated and conventional radiotherapy assessed by the tumor volume changes of paraganglioma located in the head and neck region concerning fractional and total doses. Methods We analyzed 76 patients a...
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| Format: | Article |
| Language: | English |
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Wiley
2024-09-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.70232 |
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| author | Paweł J. Polanowski Agnieszka R. Kotecka‐Blicharz Andrzej Tukiendorf Natalia J. Amrogowicz Aleksandra M. Nasiek Agnieszka Pietruszka Katarzyna M. Polanowska Krzysztof A. Składowski |
| author_facet | Paweł J. Polanowski Agnieszka R. Kotecka‐Blicharz Andrzej Tukiendorf Natalia J. Amrogowicz Aleksandra M. Nasiek Agnieszka Pietruszka Katarzyna M. Polanowska Krzysztof A. Składowski |
| author_sort | Paweł J. Polanowski |
| collection | DOAJ |
| description | Abstract Background The aim of this study is comparison the effectiveness of stereotactic, hypofractionated and conventional radiotherapy assessed by the tumor volume changes of paraganglioma located in the head and neck region concerning fractional and total doses. Methods We analyzed 76 patients after radiotherapy due to paraganglioma who were assigned to 3 groups considering fractional (≤2 Gy, 3–5.5 Gy, ≥6 Gy) and total (≤20 Gy, 21–40 Gy, >40 Gy) doses. The volumes of irradiated tumors were measured and compared based on diagnostic images performed before and after the treatment. Results The mean tumor volume after the treatment with the lowest fractional dose (≤2 Gy) was decreased by 14.4 cm3. In patients treated with higher fractional doses (>2 Gy), the mean tumor volumes decreased by less than 1 cm3 for hypofractionated and stereotactic radiotherapy. 15.9 cm3 reduction of the mean tumor volume after the treatment with the highest RT total dose (>40 Gy) was stated. In patients treated with total doses ≤20 Gy and 21–40 Gy, the mean tumor volume was stable and reduced by 1.15 cm3, respectively. The analysis demonstrates a statistically significant (p < 0.05) treatment advantage in patients after the lowest fractional and highest total doses. Conclusion The reduction of the tumor's volume was reported after conventional and unconventional radiotherapy. The most significant depletion of the paraganglioma volume was noted after a factional dose ≤2 Gy and a total dose >40 Gy. |
| format | Article |
| id | doaj-art-4bfcc05faeb04d35a843f8a960140e05 |
| institution | Kabale University |
| issn | 2045-7634 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-4bfcc05faeb04d35a843f8a960140e052025-02-07T09:08:08ZengWileyCancer Medicine2045-76342024-09-011317n/an/a10.1002/cam4.70232Tumor volume changes after stereotactic, hypofractionated and conventional radiotherapy in paragangliomas of head and neckPaweł J. Polanowski0Agnieszka R. Kotecka‐Blicharz1Andrzej Tukiendorf2Natalia J. Amrogowicz3Aleksandra M. Nasiek4Agnieszka Pietruszka5Katarzyna M. Polanowska6Krzysztof A. Składowski7First Radiation and Clinical Oncology Department Maria Sklodowska‐Curie National Research Institute of Oncology Gliwice PolandDepartment of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie National Research Institute of Oncology Gliwice PolandInstitute of Health Sciences, Opole University Opole PolandFirst Radiation and Clinical Oncology Department Maria Sklodowska‐Curie National Research Institute of Oncology Gliwice PolandFirst Radiation and Clinical Oncology Department Maria Sklodowska‐Curie National Research Institute of Oncology Gliwice PolandDepartment of Clinical Oncology Maria Sklodowska‐Curie National Research Institute of Oncology Cracow PolandOphthalmology Department St. Barbara Provincial Hospital No 5 Sosnowiec PolandFirst Radiation and Clinical Oncology Department Maria Sklodowska‐Curie National Research Institute of Oncology Gliwice PolandAbstract Background The aim of this study is comparison the effectiveness of stereotactic, hypofractionated and conventional radiotherapy assessed by the tumor volume changes of paraganglioma located in the head and neck region concerning fractional and total doses. Methods We analyzed 76 patients after radiotherapy due to paraganglioma who were assigned to 3 groups considering fractional (≤2 Gy, 3–5.5 Gy, ≥6 Gy) and total (≤20 Gy, 21–40 Gy, >40 Gy) doses. The volumes of irradiated tumors were measured and compared based on diagnostic images performed before and after the treatment. Results The mean tumor volume after the treatment with the lowest fractional dose (≤2 Gy) was decreased by 14.4 cm3. In patients treated with higher fractional doses (>2 Gy), the mean tumor volumes decreased by less than 1 cm3 for hypofractionated and stereotactic radiotherapy. 15.9 cm3 reduction of the mean tumor volume after the treatment with the highest RT total dose (>40 Gy) was stated. In patients treated with total doses ≤20 Gy and 21–40 Gy, the mean tumor volume was stable and reduced by 1.15 cm3, respectively. The analysis demonstrates a statistically significant (p < 0.05) treatment advantage in patients after the lowest fractional and highest total doses. Conclusion The reduction of the tumor's volume was reported after conventional and unconventional radiotherapy. The most significant depletion of the paraganglioma volume was noted after a factional dose ≤2 Gy and a total dose >40 Gy.https://doi.org/10.1002/cam4.70232conventional radiotherapyhead and neckhypofractionated radiotherapyparagangliomasstereotactic radiotherapy |
| spellingShingle | Paweł J. Polanowski Agnieszka R. Kotecka‐Blicharz Andrzej Tukiendorf Natalia J. Amrogowicz Aleksandra M. Nasiek Agnieszka Pietruszka Katarzyna M. Polanowska Krzysztof A. Składowski Tumor volume changes after stereotactic, hypofractionated and conventional radiotherapy in paragangliomas of head and neck Cancer Medicine conventional radiotherapy head and neck hypofractionated radiotherapy paragangliomas stereotactic radiotherapy |
| title | Tumor volume changes after stereotactic, hypofractionated and conventional radiotherapy in paragangliomas of head and neck |
| title_full | Tumor volume changes after stereotactic, hypofractionated and conventional radiotherapy in paragangliomas of head and neck |
| title_fullStr | Tumor volume changes after stereotactic, hypofractionated and conventional radiotherapy in paragangliomas of head and neck |
| title_full_unstemmed | Tumor volume changes after stereotactic, hypofractionated and conventional radiotherapy in paragangliomas of head and neck |
| title_short | Tumor volume changes after stereotactic, hypofractionated and conventional radiotherapy in paragangliomas of head and neck |
| title_sort | tumor volume changes after stereotactic hypofractionated and conventional radiotherapy in paragangliomas of head and neck |
| topic | conventional radiotherapy head and neck hypofractionated radiotherapy paragangliomas stereotactic radiotherapy |
| url | https://doi.org/10.1002/cam4.70232 |
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