A Lipidomic Analysis of Placenta in Preeclampsia: Evidence for Lipid Storage.
In preeclampsia, maternal insulin resistance leads to defective expansion of adipocytes, enhanced adipocyte lipolysis, up-regulation of very low density lipoprotein synthesis, maternal hypertriglyceridaemia and the potential for ectopic fat storage. Our aim was to quantitate and compare the total am...
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0163972&type=printable |
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| author | Simon H J Brown Samuel R Eather Dilys J Freeman Barbara J Meyer Todd W Mitchell |
| author_facet | Simon H J Brown Samuel R Eather Dilys J Freeman Barbara J Meyer Todd W Mitchell |
| author_sort | Simon H J Brown |
| collection | DOAJ |
| description | In preeclampsia, maternal insulin resistance leads to defective expansion of adipocytes, enhanced adipocyte lipolysis, up-regulation of very low density lipoprotein synthesis, maternal hypertriglyceridaemia and the potential for ectopic fat storage. Our aim was to quantitate and compare the total amount and type of lipid in placenta from pregnancies complicated with preeclampsia and healthy pregnancies. Quantitative lipid analysis of lipid extracts from full thickness placental biopsies was carried out by shotgun lipidomics. Placental lipid profiles from pregnancies complicated by preeclampsia (n = 23) were compared to healthy pregnancies (n = 68), and placenta from intrauterine growth restriction pregnancies (n = 10) were used to control for gross differences in placental pathology. Placentae from pregnancies complicated with preeclampsia had higher neutral lipid content than healthy placentae (40% higher triacyglycerol (P = 0.001) and 33% higher cholesteryl ester (P = 0.004)) that was specific to preeclampsia and independent of maternal gestation. |
| format | Article |
| id | doaj-art-4bfc2fd8afe144f2bfd234eb12612159 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-4bfc2fd8afe144f2bfd234eb126121592025-08-20T03:24:29ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01119e016397210.1371/journal.pone.0163972A Lipidomic Analysis of Placenta in Preeclampsia: Evidence for Lipid Storage.Simon H J BrownSamuel R EatherDilys J FreemanBarbara J MeyerTodd W MitchellIn preeclampsia, maternal insulin resistance leads to defective expansion of adipocytes, enhanced adipocyte lipolysis, up-regulation of very low density lipoprotein synthesis, maternal hypertriglyceridaemia and the potential for ectopic fat storage. Our aim was to quantitate and compare the total amount and type of lipid in placenta from pregnancies complicated with preeclampsia and healthy pregnancies. Quantitative lipid analysis of lipid extracts from full thickness placental biopsies was carried out by shotgun lipidomics. Placental lipid profiles from pregnancies complicated by preeclampsia (n = 23) were compared to healthy pregnancies (n = 68), and placenta from intrauterine growth restriction pregnancies (n = 10) were used to control for gross differences in placental pathology. Placentae from pregnancies complicated with preeclampsia had higher neutral lipid content than healthy placentae (40% higher triacyglycerol (P = 0.001) and 33% higher cholesteryl ester (P = 0.004)) that was specific to preeclampsia and independent of maternal gestation.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0163972&type=printable |
| spellingShingle | Simon H J Brown Samuel R Eather Dilys J Freeman Barbara J Meyer Todd W Mitchell A Lipidomic Analysis of Placenta in Preeclampsia: Evidence for Lipid Storage. PLoS ONE |
| title | A Lipidomic Analysis of Placenta in Preeclampsia: Evidence for Lipid Storage. |
| title_full | A Lipidomic Analysis of Placenta in Preeclampsia: Evidence for Lipid Storage. |
| title_fullStr | A Lipidomic Analysis of Placenta in Preeclampsia: Evidence for Lipid Storage. |
| title_full_unstemmed | A Lipidomic Analysis of Placenta in Preeclampsia: Evidence for Lipid Storage. |
| title_short | A Lipidomic Analysis of Placenta in Preeclampsia: Evidence for Lipid Storage. |
| title_sort | lipidomic analysis of placenta in preeclampsia evidence for lipid storage |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0163972&type=printable |
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