Changes in anaphylaxis trends and characteristics in emergency department admissions in Türkiye: From 2015 to 2021 based on the Ministry of Health database
Background: The incidence of anaphylaxis is increasing worldwide. However, there is a lack of data on anaphylaxis trends in Türkiye. This study aims to analyse trends in anaphylaxis-related emergency department (ED) visits and examines factors associated with fatal anaphylaxis in Türkiye. Methods: W...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | World Allergy Organization Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1939455124001510 |
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| author | Elif Soyak Aytekin, MD Seda Şirin, MD Esra Kıratlı Nalbant, MD Naim Ata, MD Ahmet Sertçelik, MD Mustafa Mahir Ülgü, MD Şuayip Birinci, MD Koray Harmancı, MD Zülfikar Akelma, MD |
| author_facet | Elif Soyak Aytekin, MD Seda Şirin, MD Esra Kıratlı Nalbant, MD Naim Ata, MD Ahmet Sertçelik, MD Mustafa Mahir Ülgü, MD Şuayip Birinci, MD Koray Harmancı, MD Zülfikar Akelma, MD |
| author_sort | Elif Soyak Aytekin, MD |
| collection | DOAJ |
| description | Background: The incidence of anaphylaxis is increasing worldwide. However, there is a lack of data on anaphylaxis trends in Türkiye. This study aims to analyse trends in anaphylaxis-related emergency department (ED) visits and examines factors associated with fatal anaphylaxis in Türkiye. Methods: We retrospectively analyzed data from Türkiye's Ministry of Health database from 2015 to 2022. Codes from the International Classification of Diseases, 10th revision (ICD-10), were used to identify anaphylaxis. Results: During the study period, a total 21,370 ED admissions for anaphylaxis were identified, and anaphylaxis admissions increased 1.23-fold from 3.90 to 4.79 per 105 population per year. The anaphylaxis trigger was unknown in 79.9% of cases, followed by drugs (11.7%), food (5.7%) and venom (2.7%). Epinephrine was administered in 49.6% of cases, and a total of 424 patients (2.1% of total cases) died. The frequency of intensive care unit (ICU) hospitalization increased 6.0-fold from 2015 to 2021, and age-adjusted average-weighted mortality rate for anaphylaxis was 0.66 per million. Older age, presence of asthma, and ICU hospitalization were found to be significantly associated with fatal anaphylaxis (p < 0.001 for all). Frequencies of death were 9.1% for venom anaphylaxis, 1.2% in drug anaphylaxis, and 0.2% for food anaphylaxis. Epinephrine autoinjector (EAI) was prescribed for 6.9% of all patients. Conclusions: This is the first study of ED admissions for anaphylaxis using a large, nationwide data from Türkiye. Increasing numbers of ED admissions, ICU hospitalizations and mortality show that anaphylaxis is an important public health issue in Türkiye. |
| format | Article |
| id | doaj-art-4bfadfb5964b439b9a03b5d56fcb4041 |
| institution | Kabale University |
| issn | 1939-4551 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Allergy Organization Journal |
| spelling | doaj-art-4bfadfb5964b439b9a03b5d56fcb40412025-01-17T04:49:17ZengElsevierWorld Allergy Organization Journal1939-45512025-01-01181101019Changes in anaphylaxis trends and characteristics in emergency department admissions in Türkiye: From 2015 to 2021 based on the Ministry of Health databaseElif Soyak Aytekin, MD0Seda Şirin, MD1Esra Kıratlı Nalbant, MD2Naim Ata, MD3Ahmet Sertçelik, MD4Mustafa Mahir Ülgü, MD5Şuayip Birinci, MD6Koray Harmancı, MD7Zülfikar Akelma, MD8Pediatric Allergy and Immunology Clinic, Ankara Etlik City Hospital, Ankara, TurkeyDepartment of Pediatric Allergy and Immunology, Ankara Yıldırım Beyazıt University, Ankara, Turkey; Pediatric Allergy and Immunology Clinic, Ankara Etlik City Hospital, Ankara, TurkeyDepartment of Dermatology, Ankara Yıldırım Beyazıt University, Ankara, TurkeyDepartment of Strategy Development, Republic of Turkey, Ministry of Health, Ankara, TurkeyDepartment of Public Health, Division of Epidemiology, Faculty of Medicine, Hacettepe University, Ankara, TurkeyGeneral Directorate of Health Information Systems, Republic of Turkey, Ministry of Health, Ankara, TurkeyRepublic of Turkey, Ministry of Health, Ankara, TurkeyDepartment of Pediatric Allergy and Immunology, Eskisehir Osmangazi University, Eskisehir, TurkeyDepartment of Pediatric Allergy and Immunology, Ankara Yıldırım Beyazıt University, Ankara, Turkey; Pediatric Allergy and Immunology Clinic, Ankara Bilkent City Hospital, Ankara, Turkey; Corresponding author. Pediatric Allergy and Immunology Clinic, Ankara Bilkent City Hospital, Ankara, Turkey.Background: The incidence of anaphylaxis is increasing worldwide. However, there is a lack of data on anaphylaxis trends in Türkiye. This study aims to analyse trends in anaphylaxis-related emergency department (ED) visits and examines factors associated with fatal anaphylaxis in Türkiye. Methods: We retrospectively analyzed data from Türkiye's Ministry of Health database from 2015 to 2022. Codes from the International Classification of Diseases, 10th revision (ICD-10), were used to identify anaphylaxis. Results: During the study period, a total 21,370 ED admissions for anaphylaxis were identified, and anaphylaxis admissions increased 1.23-fold from 3.90 to 4.79 per 105 population per year. The anaphylaxis trigger was unknown in 79.9% of cases, followed by drugs (11.7%), food (5.7%) and venom (2.7%). Epinephrine was administered in 49.6% of cases, and a total of 424 patients (2.1% of total cases) died. The frequency of intensive care unit (ICU) hospitalization increased 6.0-fold from 2015 to 2021, and age-adjusted average-weighted mortality rate for anaphylaxis was 0.66 per million. Older age, presence of asthma, and ICU hospitalization were found to be significantly associated with fatal anaphylaxis (p < 0.001 for all). Frequencies of death were 9.1% for venom anaphylaxis, 1.2% in drug anaphylaxis, and 0.2% for food anaphylaxis. Epinephrine autoinjector (EAI) was prescribed for 6.9% of all patients. Conclusions: This is the first study of ED admissions for anaphylaxis using a large, nationwide data from Türkiye. Increasing numbers of ED admissions, ICU hospitalizations and mortality show that anaphylaxis is an important public health issue in Türkiye.http://www.sciencedirect.com/science/article/pii/S1939455124001510AnaphylaxisEmergency departmentEpinephrine autoinjectorFatal anaphylaxisMortalityTürkiye |
| spellingShingle | Elif Soyak Aytekin, MD Seda Şirin, MD Esra Kıratlı Nalbant, MD Naim Ata, MD Ahmet Sertçelik, MD Mustafa Mahir Ülgü, MD Şuayip Birinci, MD Koray Harmancı, MD Zülfikar Akelma, MD Changes in anaphylaxis trends and characteristics in emergency department admissions in Türkiye: From 2015 to 2021 based on the Ministry of Health database World Allergy Organization Journal Anaphylaxis Emergency department Epinephrine autoinjector Fatal anaphylaxis Mortality Türkiye |
| title | Changes in anaphylaxis trends and characteristics in emergency department admissions in Türkiye: From 2015 to 2021 based on the Ministry of Health database |
| title_full | Changes in anaphylaxis trends and characteristics in emergency department admissions in Türkiye: From 2015 to 2021 based on the Ministry of Health database |
| title_fullStr | Changes in anaphylaxis trends and characteristics in emergency department admissions in Türkiye: From 2015 to 2021 based on the Ministry of Health database |
| title_full_unstemmed | Changes in anaphylaxis trends and characteristics in emergency department admissions in Türkiye: From 2015 to 2021 based on the Ministry of Health database |
| title_short | Changes in anaphylaxis trends and characteristics in emergency department admissions in Türkiye: From 2015 to 2021 based on the Ministry of Health database |
| title_sort | changes in anaphylaxis trends and characteristics in emergency department admissions in turkiye from 2015 to 2021 based on the ministry of health database |
| topic | Anaphylaxis Emergency department Epinephrine autoinjector Fatal anaphylaxis Mortality Türkiye |
| url | http://www.sciencedirect.com/science/article/pii/S1939455124001510 |
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