Engineering the mechanical characteristics of regenerated silk fibroin materials: the impact of chemical and physical modification strategies
In this study, an in-depth exploration was conducted on the mechanical properties of regenerated silk fibroin (RSF) materials through diverse processing modalities, encompassing wet pressing, humidity treatments at varying levels, and the incorporation of plasticizers. Notably, these approaches indu...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2025.1606995/full |
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| author | Haitao Guan Haitao Guan Fang Ding Ye Xue Ye Xue Jinli Zhao |
| author_facet | Haitao Guan Haitao Guan Fang Ding Ye Xue Ye Xue Jinli Zhao |
| author_sort | Haitao Guan |
| collection | DOAJ |
| description | In this study, an in-depth exploration was conducted on the mechanical properties of regenerated silk fibroin (RSF) materials through diverse processing modalities, encompassing wet pressing, humidity treatments at varying levels, and the incorporation of plasticizers. Notably, these approaches induced substantial modifications in the mechanical properties of RSF materials. The elastic strength of RSF exhibited a wide range, from 12.6 to 1,644.8 MPa; the ultimate strength spanned from 0.12 to 42.63 MPa, and the maximum elongation at break fluctuated between 0.67% and 614.38%. Additionally, the mechanisms underlying the effects of these distinct treatment methods were meticulously investigated. This fundamental research not only provides crucial insights into the modulation of silk fibroin’s mechanical properties but also holds significant promise for broadening its applications in the biomedical engineering domain, particularly in the pivotal fields of bone tissue and tendon regeneration. |
| format | Article |
| id | doaj-art-4bf98f8445f2444fa89ce1b148d26e57 |
| institution | DOAJ |
| issn | 2296-2646 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj-art-4bf98f8445f2444fa89ce1b148d26e572025-08-20T03:10:20ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462025-06-011310.3389/fchem.2025.16069951606995Engineering the mechanical characteristics of regenerated silk fibroin materials: the impact of chemical and physical modification strategiesHaitao Guan0Haitao Guan1Fang Ding2Ye Xue3Ye Xue4Jinli Zhao5Clinical Innovation Research Center of Nantong University-Nantong Hospital of Traditional Chinese Medicine, Nantong University, Nantong, Jiangsu, ChinaDepartment of Pain and Ultrasonography, Nantong Hospital Affiliated to Nanjing University of Chinese Medicine, Nantong, Jiangsu, ChinaDepartment of Imaging, Nantong Hospital Affiliated to Nanjing University of Chinese Medicine, Nantong, Jiangsu, ChinaClinical Innovation Research Center of Nantong University-Nantong Hospital of Traditional Chinese Medicine, Nantong University, Nantong, Jiangsu, ChinaSchool of Life Sciences, Nantong University, Nantong, Jiangsu, ChinaDepartment of Imaging, Affiliated Hospital of Nantong University, Nantong, Jiangsu, ChinaIn this study, an in-depth exploration was conducted on the mechanical properties of regenerated silk fibroin (RSF) materials through diverse processing modalities, encompassing wet pressing, humidity treatments at varying levels, and the incorporation of plasticizers. Notably, these approaches induced substantial modifications in the mechanical properties of RSF materials. The elastic strength of RSF exhibited a wide range, from 12.6 to 1,644.8 MPa; the ultimate strength spanned from 0.12 to 42.63 MPa, and the maximum elongation at break fluctuated between 0.67% and 614.38%. Additionally, the mechanisms underlying the effects of these distinct treatment methods were meticulously investigated. This fundamental research not only provides crucial insights into the modulation of silk fibroin’s mechanical properties but also holds significant promise for broadening its applications in the biomedical engineering domain, particularly in the pivotal fields of bone tissue and tendon regeneration.https://www.frontiersin.org/articles/10.3389/fchem.2025.1606995/fullregenerated silk fibroinmechanical propertyplasticizerchemical modificationnatural polymer |
| spellingShingle | Haitao Guan Haitao Guan Fang Ding Ye Xue Ye Xue Jinli Zhao Engineering the mechanical characteristics of regenerated silk fibroin materials: the impact of chemical and physical modification strategies Frontiers in Chemistry regenerated silk fibroin mechanical property plasticizer chemical modification natural polymer |
| title | Engineering the mechanical characteristics of regenerated silk fibroin materials: the impact of chemical and physical modification strategies |
| title_full | Engineering the mechanical characteristics of regenerated silk fibroin materials: the impact of chemical and physical modification strategies |
| title_fullStr | Engineering the mechanical characteristics of regenerated silk fibroin materials: the impact of chemical and physical modification strategies |
| title_full_unstemmed | Engineering the mechanical characteristics of regenerated silk fibroin materials: the impact of chemical and physical modification strategies |
| title_short | Engineering the mechanical characteristics of regenerated silk fibroin materials: the impact of chemical and physical modification strategies |
| title_sort | engineering the mechanical characteristics of regenerated silk fibroin materials the impact of chemical and physical modification strategies |
| topic | regenerated silk fibroin mechanical property plasticizer chemical modification natural polymer |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2025.1606995/full |
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