Exploring the therapeutic potential and in vitro validation of baicalin for the treatment of triple-negative breast cancer

Exploring the therapeutic potential and in vitro validation of baicalin for the treatment of triple-negative breast cancer

ObjectiveTo explore the mechanism of action of baicalin (BA) in the treatment of triple-negative breast cancer (TNBC) based on network pharmacology, molecular docking and molecular dynamics simulations and in vitro validation.MethodsThe inhibitory effects of different concentrations of baicalin on t...

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Bibliographic Details
Main Authors: Yuan Ma, Ying Pan, Qiancheng Zhao, Chongheng Zhang, Haitao He, Lihua Pan, Jianling Jia, Aiping Shi, Yiming Yang, Wenfeng Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
baicalin
triple-negative breast cancer
molecular dynamics simulation
molecular docking
network pharmacology
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1530056/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1530056/full

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