Protective Activity of Ingavirin® in Experimental Lethal Influenza Due to Pandemic Influenza Virus A (H1N1)v (Albino Mice)
Despite obvious success in the vaccine development and chemotherapy of influenza, it remains a poorly controlled infection leading to emergence of new pandemic variants of the virus with high morbidity and mortality. We investigated the protective activity of Ingavirin® against the lethal influenza...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2020-05-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/307 |
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| author | V. V. Zarubaev A. V. Garshinina N. A. Kalinina A. A. Shtro S. V. Belyaevskaya V. E. Nebolsin O. I. Kiselev |
| author_facet | V. V. Zarubaev A. V. Garshinina N. A. Kalinina A. A. Shtro S. V. Belyaevskaya V. E. Nebolsin O. I. Kiselev |
| author_sort | V. V. Zarubaev |
| collection | DOAJ |
| description | Despite obvious success in the vaccine development and chemotherapy of influenza, it remains a poorly controlled infection leading to emergence of new pandemic variants of the virus with high morbidity and mortality. We investigated the protective activity of Ingavirin® against the lethal influenza A(H1N1)2009 virus infection on albine mice. Oral use of Ingavirin® resulted in sharp decreasing of the mortality (index of protection up to 57%), slight decreasing of the infectious titer of the virus in the lungs (up to 40-fold), normalizing of the body weight dynamics and the lung tissue structure vs. the placebo-treated control. The degree of the bronchial epithelium damage was also strongly decreased. The results allow to consider Ingavirin® as an effective antiviral against the current pandemic influenza virus. |
| format | Article |
| id | doaj-art-4bf62812e6ba4ce88704c606d51bb76b |
| institution | DOAJ |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-4bf62812e6ba4ce88704c606d51bb76b2025-08-20T02:49:35ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01555-62431306Protective Activity of Ingavirin® in Experimental Lethal Influenza Due to Pandemic Influenza Virus A (H1N1)v (Albino Mice)V. V. Zarubaev0A. V. Garshinina1N. A. Kalinina2A. A. Shtro3S. V. Belyaevskaya4V. E. Nebolsin5O. I. Kiselev6Research Institute of Influenza, North-West Branch of the Russian Academy of Medical SciencesResearch Institute of Influenza, North-West Branch of the Russian Academy of Medical SciencesResearch Institute of Influenza, North-West Branch of the Russian Academy of Medical SciencesResearch Institute of Influenza, North-West Branch of the Russian Academy of Medical SciencesResearch Institute of Influenza, North-West Branch of the Russian Academy of Medical SciencesJSC Valenta PharmaResearch Institute of Influenza, North-West Branch of the Russian Academy of Medical SciencesDespite obvious success in the vaccine development and chemotherapy of influenza, it remains a poorly controlled infection leading to emergence of new pandemic variants of the virus with high morbidity and mortality. We investigated the protective activity of Ingavirin® against the lethal influenza A(H1N1)2009 virus infection on albine mice. Oral use of Ingavirin® resulted in sharp decreasing of the mortality (index of protection up to 57%), slight decreasing of the infectious titer of the virus in the lungs (up to 40-fold), normalizing of the body weight dynamics and the lung tissue structure vs. the placebo-treated control. The degree of the bronchial epithelium damage was also strongly decreased. The results allow to consider Ingavirin® as an effective antiviral against the current pandemic influenza virus.https://www.antibiotics-chemotherapy.ru/jour/article/view/307influenza virus a (h1n1)albino miceingavirin® |
| spellingShingle | V. V. Zarubaev A. V. Garshinina N. A. Kalinina A. A. Shtro S. V. Belyaevskaya V. E. Nebolsin O. I. Kiselev Protective Activity of Ingavirin® in Experimental Lethal Influenza Due to Pandemic Influenza Virus A (H1N1)v (Albino Mice) Антибиотики и Химиотерапия influenza virus a (h1n1) albino mice ingavirin® |
| title | Protective Activity of Ingavirin® in Experimental Lethal Influenza Due to Pandemic Influenza Virus A (H1N1)v (Albino Mice) |
| title_full | Protective Activity of Ingavirin® in Experimental Lethal Influenza Due to Pandemic Influenza Virus A (H1N1)v (Albino Mice) |
| title_fullStr | Protective Activity of Ingavirin® in Experimental Lethal Influenza Due to Pandemic Influenza Virus A (H1N1)v (Albino Mice) |
| title_full_unstemmed | Protective Activity of Ingavirin® in Experimental Lethal Influenza Due to Pandemic Influenza Virus A (H1N1)v (Albino Mice) |
| title_short | Protective Activity of Ingavirin® in Experimental Lethal Influenza Due to Pandemic Influenza Virus A (H1N1)v (Albino Mice) |
| title_sort | protective activity of ingavirin r in experimental lethal influenza due to pandemic influenza virus a h1n1 v albino mice |
| topic | influenza virus a (h1n1) albino mice ingavirin® |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/307 |
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