Evaluation of the protective role of resveratrol on LPS-induced septic intestinal barrier function via TLR4/MyD88/NF-κB signaling pathways

Evaluation of the protective role of resveratrol on LPS-induced septic intestinal barrier function via TLR4/MyD88/NF-κB signaling pathways

Abstract The intestinal barrier function is a critical defense mechanism in the human body, serving as both the primary target and initiating organ in cases of sepsis. Preserving the integrity of this barrier is essential for preventing complications and diseases, including sepsis and mortality. Des...

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Bibliographic Details
Main Authors: Zhongliang Shi, Yanna Jiao, Zhizhen Lai, Juan Liu, Bo Yang, Mahong Hu, Jianbiao Meng
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Resveratrol
Sepsis
Intestinal barrier dysfunction
Apoptosis
Tight junction
TLR4/MyD88/NF-κB signaling pathway
Online Access:https://doi.org/10.1038/s41598-025-85148-2
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