Accumulation of a bioactive benzoisochromanequinone compound kalafungin by a wild type antitumor-medermycin-producing streptomycete strain.
Medermycin and kalafungin, two antibacterial and antitumor antibiotics isolated from different streptomycetes, share an identical polyketide skeleton core. The present study reported the discovery of kalafungin in a medermycin-producing streptomycete strain for the first time. A mutant strain obtain...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0117690&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850023044472373248 |
|---|---|
| author | Jin Lü Qiang He Luyao Huang Xiaofeng Cai Wenwen Guo Jing He Lili Zhang Aiying Li |
| author_facet | Jin Lü Qiang He Luyao Huang Xiaofeng Cai Wenwen Guo Jing He Lili Zhang Aiying Li |
| author_sort | Jin Lü |
| collection | DOAJ |
| description | Medermycin and kalafungin, two antibacterial and antitumor antibiotics isolated from different streptomycetes, share an identical polyketide skeleton core. The present study reported the discovery of kalafungin in a medermycin-producing streptomycete strain for the first time. A mutant strain obtained through UV mutagenesis showed a 3-fold increase in the production of this antibiotic, compared to the wild type strain. Heterologous expression experiments suggested that its production was severely controlled by the gene cluster for medermycin biosynthesis. In all, these findings suggested that kalafungin and medermycin could be accumulated by the same streptomycete and share their biosynthetic pathway to some extent in this strain. |
| format | Article |
| id | doaj-art-4bef4a0096654ec08e65bc5bcf8bc025 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-4bef4a0096654ec08e65bc5bcf8bc0252025-08-20T03:01:30ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01102e011769010.1371/journal.pone.0117690Accumulation of a bioactive benzoisochromanequinone compound kalafungin by a wild type antitumor-medermycin-producing streptomycete strain.Jin LüQiang HeLuyao HuangXiaofeng CaiWenwen GuoJing HeLili ZhangAiying LiMedermycin and kalafungin, two antibacterial and antitumor antibiotics isolated from different streptomycetes, share an identical polyketide skeleton core. The present study reported the discovery of kalafungin in a medermycin-producing streptomycete strain for the first time. A mutant strain obtained through UV mutagenesis showed a 3-fold increase in the production of this antibiotic, compared to the wild type strain. Heterologous expression experiments suggested that its production was severely controlled by the gene cluster for medermycin biosynthesis. In all, these findings suggested that kalafungin and medermycin could be accumulated by the same streptomycete and share their biosynthetic pathway to some extent in this strain.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0117690&type=printable |
| spellingShingle | Jin Lü Qiang He Luyao Huang Xiaofeng Cai Wenwen Guo Jing He Lili Zhang Aiying Li Accumulation of a bioactive benzoisochromanequinone compound kalafungin by a wild type antitumor-medermycin-producing streptomycete strain. PLoS ONE |
| title | Accumulation of a bioactive benzoisochromanequinone compound kalafungin by a wild type antitumor-medermycin-producing streptomycete strain. |
| title_full | Accumulation of a bioactive benzoisochromanequinone compound kalafungin by a wild type antitumor-medermycin-producing streptomycete strain. |
| title_fullStr | Accumulation of a bioactive benzoisochromanequinone compound kalafungin by a wild type antitumor-medermycin-producing streptomycete strain. |
| title_full_unstemmed | Accumulation of a bioactive benzoisochromanequinone compound kalafungin by a wild type antitumor-medermycin-producing streptomycete strain. |
| title_short | Accumulation of a bioactive benzoisochromanequinone compound kalafungin by a wild type antitumor-medermycin-producing streptomycete strain. |
| title_sort | accumulation of a bioactive benzoisochromanequinone compound kalafungin by a wild type antitumor medermycin producing streptomycete strain |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0117690&type=printable |
| work_keys_str_mv | AT jinlu accumulationofabioactivebenzoisochromanequinonecompoundkalafunginbyawildtypeantitumormedermycinproducingstreptomycetestrain AT qianghe accumulationofabioactivebenzoisochromanequinonecompoundkalafunginbyawildtypeantitumormedermycinproducingstreptomycetestrain AT luyaohuang accumulationofabioactivebenzoisochromanequinonecompoundkalafunginbyawildtypeantitumormedermycinproducingstreptomycetestrain AT xiaofengcai accumulationofabioactivebenzoisochromanequinonecompoundkalafunginbyawildtypeantitumormedermycinproducingstreptomycetestrain AT wenwenguo accumulationofabioactivebenzoisochromanequinonecompoundkalafunginbyawildtypeantitumormedermycinproducingstreptomycetestrain AT jinghe accumulationofabioactivebenzoisochromanequinonecompoundkalafunginbyawildtypeantitumormedermycinproducingstreptomycetestrain AT lilizhang accumulationofabioactivebenzoisochromanequinonecompoundkalafunginbyawildtypeantitumormedermycinproducingstreptomycetestrain AT aiyingli accumulationofabioactivebenzoisochromanequinonecompoundkalafunginbyawildtypeantitumormedermycinproducingstreptomycetestrain |