Chest wall reconstruction with implantable cross-linked porcine dermal collagen matrix: Evaluation of clinical outcomesCentral MessagePerspective
Objectives: The aim of the study is to evaluate clinical applications, safety, and effectiveness of a porcine-derived acellular cross-linked dermal matrix biological mesh in chest wall reconstruction. Methods: We retrospectively analyzed a prospective multicenter database of chest wall reconstructio...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | JTCVS Techniques |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666250722001006 |
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| author | Alessandro Gonfiotti, MD, PhD Domenico Viggiano, MD Eduart Vokrri, MD Marco Lucchi, MD, PhD Duilio Divisi, MD, PhD Roberto Crisci, MD, PhD Felice Mucilli, MD Federico Venuta, MD, PhD Luca Voltolini, MD, PhD |
| author_facet | Alessandro Gonfiotti, MD, PhD Domenico Viggiano, MD Eduart Vokrri, MD Marco Lucchi, MD, PhD Duilio Divisi, MD, PhD Roberto Crisci, MD, PhD Felice Mucilli, MD Federico Venuta, MD, PhD Luca Voltolini, MD, PhD |
| author_sort | Alessandro Gonfiotti, MD, PhD |
| collection | DOAJ |
| description | Objectives: The aim of the study is to evaluate clinical applications, safety, and effectiveness of a porcine-derived acellular cross-linked dermal matrix biological mesh in chest wall reconstruction. Methods: We retrospectively analyzed a prospective multicenter database of chest wall reconstructions using a biological mesh in adult patients undergoing operation between October 2013 and December 2020. We evaluated preoperative data, type of resection and reconstruction, hospitalization, 30-day morbidity and mortality, and overall survival. Results: A total of 105 patients (36 women [34.2%]; mean age, 57.0 ± 16.1 years; range, 18-90 years) were included, they have admitted for: primary chest wall tumor (n = 52; 49.5%), secondary chest wall tumor (n = 29; 27.6%), lung hernia (n = 12; 11.4%), trauma (n = 10; 9.6%), and infections (n = 2; 1.9%). The surgical sites were preoperatively defined as at high risk of infection in 28 patients (26.7%) or as infected in 16 (15.2%) patients. Thirty-days morbidity was 30.5% (n = 32 patients); 14 patients (13.3%) had postoperative complications directly related to chest wall surgical resection and/or reconstruction. We experienced no 30-day mortality; 1-year and 2-year mortality was 8.4% and 16.8%, respectively. Conclusions: Biological mesh represents a valuable option in chest wall reconstruction even when surgical sites are infected or at high-risk of infections. This mesh shows low early and late postoperative complication rates and excellent long-term stability. |
| format | Article |
| id | doaj-art-4beedc4b81a94f3cab488d0592b90dc0 |
| institution | Kabale University |
| issn | 2666-2507 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JTCVS Techniques |
| spelling | doaj-art-4beedc4b81a94f3cab488d0592b90dc02025-08-20T03:36:37ZengElsevierJTCVS Techniques2666-25072022-06-011325026010.1016/j.xjtc.2022.01.021Chest wall reconstruction with implantable cross-linked porcine dermal collagen matrix: Evaluation of clinical outcomesCentral MessagePerspectiveAlessandro Gonfiotti, MD, PhD0Domenico Viggiano, MD1Eduart Vokrri, MD2Marco Lucchi, MD, PhD3Duilio Divisi, MD, PhD4Roberto Crisci, MD, PhD5Felice Mucilli, MD6Federico Venuta, MD, PhD7Luca Voltolini, MD, PhD8Section of Thoracic Surgery, Department of Cardio-Thoracic and Vascular Surgery, Azienda Ospedaliero Universitaria Careggi, Firenze, Italy; Address for reprints: Alessandro Gonfiotti, MD, PhD, Thoracic Surgery Unit, Careggi University Hospital, Largo Brambilla, 3, 50134 Florence, Italy.Section of Thoracic Surgery, Department of Cardio-Thoracic and Vascular Surgery, Azienda Ospedaliero Universitaria Careggi, Firenze, ItalySection of Thoracic Surgery, Department of Cardio-Thoracic and Vascular Surgery, Azienda Ospedaliero Universitaria Careggi, Firenze, ItalySection of Thoracic Surgery, Department of Cardio-Thoracic and Vascular, Azienda Ospedaliero Universitaria Pisana, Pisa, ItalyThoracic Surgery Unit, Ospedale Civile Giuseppe Mazzini, Università degli Studi L'Aquila, Teramo, ItalyThoracic Surgery Unit, Ospedale Civile Giuseppe Mazzini, Università degli Studi L'Aquila, Teramo, ItalyGeneral and Thoracic Surgery, Department of Medical Science, Università degli Studi G. d'Annunzio, Chieti-Pescara, ItalyThoracic Surgery Unit, Azienda Ospedaliero Universitaria Policlinico Umberto I, Roma, ItalySection of Thoracic Surgery, Department of Cardio-Thoracic and Vascular Surgery, Azienda Ospedaliero Universitaria Careggi, Firenze, ItalyObjectives: The aim of the study is to evaluate clinical applications, safety, and effectiveness of a porcine-derived acellular cross-linked dermal matrix biological mesh in chest wall reconstruction. Methods: We retrospectively analyzed a prospective multicenter database of chest wall reconstructions using a biological mesh in adult patients undergoing operation between October 2013 and December 2020. We evaluated preoperative data, type of resection and reconstruction, hospitalization, 30-day morbidity and mortality, and overall survival. Results: A total of 105 patients (36 women [34.2%]; mean age, 57.0 ± 16.1 years; range, 18-90 years) were included, they have admitted for: primary chest wall tumor (n = 52; 49.5%), secondary chest wall tumor (n = 29; 27.6%), lung hernia (n = 12; 11.4%), trauma (n = 10; 9.6%), and infections (n = 2; 1.9%). The surgical sites were preoperatively defined as at high risk of infection in 28 patients (26.7%) or as infected in 16 (15.2%) patients. Thirty-days morbidity was 30.5% (n = 32 patients); 14 patients (13.3%) had postoperative complications directly related to chest wall surgical resection and/or reconstruction. We experienced no 30-day mortality; 1-year and 2-year mortality was 8.4% and 16.8%, respectively. Conclusions: Biological mesh represents a valuable option in chest wall reconstruction even when surgical sites are infected or at high-risk of infections. This mesh shows low early and late postoperative complication rates and excellent long-term stability.http://www.sciencedirect.com/science/article/pii/S2666250722001006chest wall reconstructionchest wall tumorbiological meshtitanium barcross-linked porcine dermal collagen matrix |
| spellingShingle | Alessandro Gonfiotti, MD, PhD Domenico Viggiano, MD Eduart Vokrri, MD Marco Lucchi, MD, PhD Duilio Divisi, MD, PhD Roberto Crisci, MD, PhD Felice Mucilli, MD Federico Venuta, MD, PhD Luca Voltolini, MD, PhD Chest wall reconstruction with implantable cross-linked porcine dermal collagen matrix: Evaluation of clinical outcomesCentral MessagePerspective JTCVS Techniques chest wall reconstruction chest wall tumor biological mesh titanium bar cross-linked porcine dermal collagen matrix |
| title | Chest wall reconstruction with implantable cross-linked porcine dermal collagen matrix: Evaluation of clinical outcomesCentral MessagePerspective |
| title_full | Chest wall reconstruction with implantable cross-linked porcine dermal collagen matrix: Evaluation of clinical outcomesCentral MessagePerspective |
| title_fullStr | Chest wall reconstruction with implantable cross-linked porcine dermal collagen matrix: Evaluation of clinical outcomesCentral MessagePerspective |
| title_full_unstemmed | Chest wall reconstruction with implantable cross-linked porcine dermal collagen matrix: Evaluation of clinical outcomesCentral MessagePerspective |
| title_short | Chest wall reconstruction with implantable cross-linked porcine dermal collagen matrix: Evaluation of clinical outcomesCentral MessagePerspective |
| title_sort | chest wall reconstruction with implantable cross linked porcine dermal collagen matrix evaluation of clinical outcomescentral messageperspective |
| topic | chest wall reconstruction chest wall tumor biological mesh titanium bar cross-linked porcine dermal collagen matrix |
| url | http://www.sciencedirect.com/science/article/pii/S2666250722001006 |
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