Clinical and prognostic significance of matrix metalloproteinases in patients with myocardial infarction
Biomarkers are often used as a surrogate measure in the assessment of risk, severity, and prognosis of the disease. For the optimal use of biomarkers in predicting cardiovascular risk, they should demonstrate reproducibility in sequential quantitative measurements and show high sensitivity and speci...
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| Format: | Article |
| Language: | Russian |
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Kemerovo State Medical University
2019-06-01
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| Series: | Фундаментальная и клиническая медицина |
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| Online Access: | https://fcm.kemsmu.ru/jour/article/view/147 |
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| author | T. B. Pecherina O. L. Barbarash |
| author_facet | T. B. Pecherina O. L. Barbarash |
| author_sort | T. B. Pecherina |
| collection | DOAJ |
| description | Biomarkers are often used as a surrogate measure in the assessment of risk, severity, and prognosis of the disease. For the optimal use of biomarkers in predicting cardiovascular risk, they should demonstrate reproducibility in sequential quantitative measurements and show high sensitivity and specificity. In recent years, classic biomarkers of myocardial necrosis such as troponins were complemented by inflammatory markers (C-reactive protein, cytokines, matrix metalloproteinases) and markers of myocardial dysfunction (atrial and cerebral natriuretic peptides). Currently, conventional biomarkers are widely used for the timely diagnosis of myocardial infarction while an increasing number of novel markers are utilized to evaluate the risk of adverse outcomes in patients with acute coronary syndrome. |
| format | Article |
| id | doaj-art-4bed53764b674ec3a736df6d83246835 |
| institution | Kabale University |
| issn | 2500-0764 2542-0941 |
| language | Russian |
| publishDate | 2019-06-01 |
| publisher | Kemerovo State Medical University |
| record_format | Article |
| series | Фундаментальная и клиническая медицина |
| spelling | doaj-art-4bed53764b674ec3a736df6d832468352025-08-20T03:42:38ZrusKemerovo State Medical UniversityФундаментальная и клиническая медицина2500-07642542-09412019-06-0142849410.23946/2500-0764-2019-4-2-84-94146Clinical and prognostic significance of matrix metalloproteinases in patients with myocardial infarctionT. B. Pecherina0O. L. Barbarash1Research Institute for Complex Issues ofCardiovascular DiseasesResearch Institute for Complex Issues ofCardiovascular Diseases; Kemerovo State Medical UniversityBiomarkers are often used as a surrogate measure in the assessment of risk, severity, and prognosis of the disease. For the optimal use of biomarkers in predicting cardiovascular risk, they should demonstrate reproducibility in sequential quantitative measurements and show high sensitivity and specificity. In recent years, classic biomarkers of myocardial necrosis such as troponins were complemented by inflammatory markers (C-reactive protein, cytokines, matrix metalloproteinases) and markers of myocardial dysfunction (atrial and cerebral natriuretic peptides). Currently, conventional biomarkers are widely used for the timely diagnosis of myocardial infarction while an increasing number of novel markers are utilized to evaluate the risk of adverse outcomes in patients with acute coronary syndrome.https://fcm.kemsmu.ru/jour/article/view/147biomarkersmyocardial infarctionmatrix metalloproteinases |
| spellingShingle | T. B. Pecherina O. L. Barbarash Clinical and prognostic significance of matrix metalloproteinases in patients with myocardial infarction Фундаментальная и клиническая медицина biomarkers myocardial infarction matrix metalloproteinases |
| title | Clinical and prognostic significance of matrix metalloproteinases in patients with myocardial infarction |
| title_full | Clinical and prognostic significance of matrix metalloproteinases in patients with myocardial infarction |
| title_fullStr | Clinical and prognostic significance of matrix metalloproteinases in patients with myocardial infarction |
| title_full_unstemmed | Clinical and prognostic significance of matrix metalloproteinases in patients with myocardial infarction |
| title_short | Clinical and prognostic significance of matrix metalloproteinases in patients with myocardial infarction |
| title_sort | clinical and prognostic significance of matrix metalloproteinases in patients with myocardial infarction |
| topic | biomarkers myocardial infarction matrix metalloproteinases |
| url | https://fcm.kemsmu.ru/jour/article/view/147 |
| work_keys_str_mv | AT tbpecherina clinicalandprognosticsignificanceofmatrixmetalloproteinasesinpatientswithmyocardialinfarction AT olbarbarash clinicalandprognosticsignificanceofmatrixmetalloproteinasesinpatientswithmyocardialinfarction |