Mendelian randomization analysis reveals causal factors behind diabetic nephropathy: evidence, opportunities, and challenges
Diabetic nephropathy (DN), as the most serious minor vascular complication of diabetes, imposes a significant socioeconomic and medical cost around the world, and its prevention and treatment are a major challenge in the current medical community. Observational studies and randomized controlled tria...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1444808/full |
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| author | Qinchuan Huang Chen An Shiyun Tang Shiyun Tang Yulin Leng Yulin Leng Yaowen Zhang Bin Wan Yutong Han Yue Luo Chunguang Xie Chunguang Xie Chunguang Xie |
| author_facet | Qinchuan Huang Chen An Shiyun Tang Shiyun Tang Yulin Leng Yulin Leng Yaowen Zhang Bin Wan Yutong Han Yue Luo Chunguang Xie Chunguang Xie Chunguang Xie |
| author_sort | Qinchuan Huang |
| collection | DOAJ |
| description | Diabetic nephropathy (DN), as the most serious minor vascular complication of diabetes, imposes a significant socioeconomic and medical cost around the world, and its prevention and treatment are a major challenge in the current medical community. Observational studies and randomized controlled trials have revealed protective and risk factors for some DN. However, the conclusions of these researches may be influenced by several types of confounding. Mendelian randomization is a new epidemiological method mainly used to infer the causal relationship between exposure and outcome. Many Mendelian randomization studies have found potential causal relationships between DN and some diseases and lifestyle habits, thus providing valuable data for future mechanistic studies as well as the development and implementation of clinical prevention strategies. As a result, the purpose of this review is to evaluate the published Mendelian randomization study of DN, using the bibliometric research method, analyze the current research status and hot spots, and further summarize the genetic evidence about the potential protection of DN and risk factors to provide new inspiration for the etiology of DN and as a reference for clinical intervention. |
| format | Article |
| id | doaj-art-4be5d043a0364ec386c6ec7fb2433b3e |
| institution | DOAJ |
| issn | 1664-2392 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-4be5d043a0364ec386c6ec7fb2433b3e2025-08-20T02:50:30ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-12-011510.3389/fendo.2024.14448081444808Mendelian randomization analysis reveals causal factors behind diabetic nephropathy: evidence, opportunities, and challengesQinchuan Huang0Chen An1Shiyun Tang2Shiyun Tang3Yulin Leng4Yulin Leng5Yaowen Zhang6Bin Wan7Yutong Han8Yue Luo9Chunguang Xie10Chunguang Xie11Chunguang Xie12Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaWangjing Hospital Affiliated to China Academy of Chinese Medical Sciences, Beijing, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaDepartment of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaDepartment of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaDepartment of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaTraditional Chinese Medicine (TCM) Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Chengdu, Sichuan, ChinaDiabetic nephropathy (DN), as the most serious minor vascular complication of diabetes, imposes a significant socioeconomic and medical cost around the world, and its prevention and treatment are a major challenge in the current medical community. Observational studies and randomized controlled trials have revealed protective and risk factors for some DN. However, the conclusions of these researches may be influenced by several types of confounding. Mendelian randomization is a new epidemiological method mainly used to infer the causal relationship between exposure and outcome. Many Mendelian randomization studies have found potential causal relationships between DN and some diseases and lifestyle habits, thus providing valuable data for future mechanistic studies as well as the development and implementation of clinical prevention strategies. As a result, the purpose of this review is to evaluate the published Mendelian randomization study of DN, using the bibliometric research method, analyze the current research status and hot spots, and further summarize the genetic evidence about the potential protection of DN and risk factors to provide new inspiration for the etiology of DN and as a reference for clinical intervention.https://www.frontiersin.org/articles/10.3389/fendo.2024.1444808/fulldiabetic nephropathyMendelian randomizationbibliometrics analysisgenetic variationcausal relationship |
| spellingShingle | Qinchuan Huang Chen An Shiyun Tang Shiyun Tang Yulin Leng Yulin Leng Yaowen Zhang Bin Wan Yutong Han Yue Luo Chunguang Xie Chunguang Xie Chunguang Xie Mendelian randomization analysis reveals causal factors behind diabetic nephropathy: evidence, opportunities, and challenges Frontiers in Endocrinology diabetic nephropathy Mendelian randomization bibliometrics analysis genetic variation causal relationship |
| title | Mendelian randomization analysis reveals causal factors behind diabetic nephropathy: evidence, opportunities, and challenges |
| title_full | Mendelian randomization analysis reveals causal factors behind diabetic nephropathy: evidence, opportunities, and challenges |
| title_fullStr | Mendelian randomization analysis reveals causal factors behind diabetic nephropathy: evidence, opportunities, and challenges |
| title_full_unstemmed | Mendelian randomization analysis reveals causal factors behind diabetic nephropathy: evidence, opportunities, and challenges |
| title_short | Mendelian randomization analysis reveals causal factors behind diabetic nephropathy: evidence, opportunities, and challenges |
| title_sort | mendelian randomization analysis reveals causal factors behind diabetic nephropathy evidence opportunities and challenges |
| topic | diabetic nephropathy Mendelian randomization bibliometrics analysis genetic variation causal relationship |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1444808/full |
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