Peroxidasin expression is increased in intratumoural capillaries and in proximal tubular cells adjacent to clear cell renal cell carcinoma.
Peroxidasin (PXDN), is a heme peroxidase with a critical role in the crosslinking of type IV collagen, being essential for basement membrane integrity. Overexpression of PXDN has been associated with poor clinical outcomes in many cancers; however, little is currently known about its role in renal c...
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| Format: | Article |
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Elsevier
2025-09-01
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| Series: | Experimental and Molecular Pathology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0014480025000437 |
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| author | Roberto Silva Jorge Reis Almeida Ana Rita Coelho Isabel Brandão Bárbara Gomes Inês Soares Alencastre João Paulo Oliveira |
| author_facet | Roberto Silva Jorge Reis Almeida Ana Rita Coelho Isabel Brandão Bárbara Gomes Inês Soares Alencastre João Paulo Oliveira |
| author_sort | Roberto Silva |
| collection | DOAJ |
| description | Peroxidasin (PXDN), is a heme peroxidase with a critical role in the crosslinking of type IV collagen, being essential for basement membrane integrity. Overexpression of PXDN has been associated with poor clinical outcomes in many cancers; however, little is currently known about its role in renal cell carcinoma (RCC). In this study, we characterized the expression of PXDN in tumour tissue and adjacent non-neoplastic tissue from cases of clear cell renal cell carcinoma (ccRCC), chromophobe RCC (chRCC), and renal oncocytoma using immunohistochemistry. Our results revealed increased PXDN expression in the intratumoural capillaries of ccRCC compared to other tumour types, including oncocytoma. Additionally, there was a notable increase in PXDN expression in the proximal tubular epithelial cells of non-neoplastic adjacent parenchyma in ccRCC cases compared to the same region in oncocytomas. These findings suggest, for the first time, that PXDN may play a role in tumour angiogenesis, potentially promoting metastases and malignancy. Furthermore, PXDN may be involved in the crosstalk between the tumour and adjacent tissues, a mechanism warranting further investigation. |
| format | Article |
| id | doaj-art-4be574279a0e43ddbdb00503e3d65797 |
| institution | Kabale University |
| issn | 1096-0945 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Experimental and Molecular Pathology |
| spelling | doaj-art-4be574279a0e43ddbdb00503e3d657972025-08-20T05:04:02ZengElsevierExperimental and Molecular Pathology1096-09452025-09-0114310499310.1016/j.yexmp.2025.104993Peroxidasin expression is increased in intratumoural capillaries and in proximal tubular cells adjacent to clear cell renal cell carcinoma.Roberto Silva0Jorge Reis Almeida1Ana Rita Coelho2Isabel Brandão3Bárbara Gomes4Inês Soares Alencastre5João Paulo Oliveira6University of Porto – Faculty of Medicine, Pathology Department, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.; ULS São João, EPE, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.; Corresponding author at: Departamento de Patologia, Faculdade de Medicina da Universidade do Porto, Alameda Hernâni Monteiro, 4200-319 Porto, Portugal.i3S – Instituto de Investigação e Inovação em Saúde, University of Porto, R. Alfredo Allen 208, 4200-135 Porto, Portugal.University of Porto – Faculty of Medicine, Pathology Department, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.; ULS São João, EPE, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.i3S – Instituto de Investigação e Inovação em Saúde, University of Porto, R. Alfredo Allen 208, 4200-135 Porto, Portugal.; University of Porto – Instituto de Ciências Biomédicas Abel Salazar, R. de Jorge de Viterbo Ferreira 228, 4050-313 Porto, Portugal.ULS São João, EPE, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.i3S – Instituto de Investigação e Inovação em Saúde, University of Porto, R. Alfredo Allen 208, 4200-135 Porto, Portugal.; RISE – Health, University of Porto - Faculty of Medicine, Alameda Prof. HernRISE – Healthni Monteiro, 4200-319 Porto, PortugalUniversity of Porto – Faculty of Medicine, Pathology Department, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.; ULS São João, EPE, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.; i3S – Instituto de Investigação e Inovação em Saúde, University of Porto, R. Alfredo Allen 208, 4200-135 Porto, Portugal.Peroxidasin (PXDN), is a heme peroxidase with a critical role in the crosslinking of type IV collagen, being essential for basement membrane integrity. Overexpression of PXDN has been associated with poor clinical outcomes in many cancers; however, little is currently known about its role in renal cell carcinoma (RCC). In this study, we characterized the expression of PXDN in tumour tissue and adjacent non-neoplastic tissue from cases of clear cell renal cell carcinoma (ccRCC), chromophobe RCC (chRCC), and renal oncocytoma using immunohistochemistry. Our results revealed increased PXDN expression in the intratumoural capillaries of ccRCC compared to other tumour types, including oncocytoma. Additionally, there was a notable increase in PXDN expression in the proximal tubular epithelial cells of non-neoplastic adjacent parenchyma in ccRCC cases compared to the same region in oncocytomas. These findings suggest, for the first time, that PXDN may play a role in tumour angiogenesis, potentially promoting metastases and malignancy. Furthermore, PXDN may be involved in the crosstalk between the tumour and adjacent tissues, a mechanism warranting further investigation.http://www.sciencedirect.com/science/article/pii/S0014480025000437PeroxidasinClear cell renal cell carcinomaChromophobe renal cell carcinomaOncocytomaAngiogenesis |
| spellingShingle | Roberto Silva Jorge Reis Almeida Ana Rita Coelho Isabel Brandão Bárbara Gomes Inês Soares Alencastre João Paulo Oliveira Peroxidasin expression is increased in intratumoural capillaries and in proximal tubular cells adjacent to clear cell renal cell carcinoma. Experimental and Molecular Pathology Peroxidasin Clear cell renal cell carcinoma Chromophobe renal cell carcinoma Oncocytoma Angiogenesis |
| title | Peroxidasin expression is increased in intratumoural capillaries and in proximal tubular cells adjacent to clear cell renal cell carcinoma. |
| title_full | Peroxidasin expression is increased in intratumoural capillaries and in proximal tubular cells adjacent to clear cell renal cell carcinoma. |
| title_fullStr | Peroxidasin expression is increased in intratumoural capillaries and in proximal tubular cells adjacent to clear cell renal cell carcinoma. |
| title_full_unstemmed | Peroxidasin expression is increased in intratumoural capillaries and in proximal tubular cells adjacent to clear cell renal cell carcinoma. |
| title_short | Peroxidasin expression is increased in intratumoural capillaries and in proximal tubular cells adjacent to clear cell renal cell carcinoma. |
| title_sort | peroxidasin expression is increased in intratumoural capillaries and in proximal tubular cells adjacent to clear cell renal cell carcinoma |
| topic | Peroxidasin Clear cell renal cell carcinoma Chromophobe renal cell carcinoma Oncocytoma Angiogenesis |
| url | http://www.sciencedirect.com/science/article/pii/S0014480025000437 |
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